> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/trial/a-study-of-eloralintide-ly3841136-in-participants-with-e9265e1d-549c-4698-8e51-2b133f4dde1b > Record changed: 2026-10-13 # A Study of Eloralintide (LY3841136) in Participants With Obesity, or Overweight Without Type 2 Diabetes NCT07321886 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07321886) Phase Phase 3 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07321886) Recruitment status Recruiting Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07321886) Participants 1,980 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07321886) Lead sponsor Eli Lilly and Company Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07321886) Start date 2026-02-06 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07321886) Number of sites 162 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07321886) ## Title and summary **Summary** The purpose of this study is to evaluate the efficacy and safety of eloralintide in adults with obesity or overweight who do not have type 2 diabetes. The study has two phases: a main phase and an extension phase. Participation in the main phase of the study will last about 75 weeks. Participants with prediabetes will continue in the extension phase for another 2 years. Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07321886) **Acronym** ENLIGHTEN-1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07321886) **Short title** A Study of Eloralintide (LY3841136) in Participants With Obesity, or Overweight Without Type 2 Diabetes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07321886) **Official title** A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of Once Weekly Eloralintide in Adult Participants With Obesity or Overweight, Without Type 2 Diabetes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07321886) ## Status and phase **Control arm** Placebo Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07321886) **Registry reports results** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07321886) **Listing at source** Listed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07321886) **Recruitment status** Recruiting Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07321886) **Phase** Phase 3 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07321886) **Study type** Interventional Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07321886) ## Dates **Completion date** 2030-07-01 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07321886) **First posted** 2026-01-07 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07321886) **Registry last updated** 2026-08-21 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07321886) **Primary completion date** 2028-03-01 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07321886) **Start date** 2026-02-06 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07321886) ## Size and sites **Participants** 1,980 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07321886) **Participant count basis** Estimated Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07321886) **Planned participants** 1,980 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07321886) **Protocol amendments** 0 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07321886) **Number of sites** 162 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07321886) ## Sponsor and oversight **Data monitoring committee** Yes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07321886) **Registry sponsor category** Industry Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07321886) **Lead sponsor** Eli Lilly and Company Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07321886) **Source registry** ClinicalTrials.gov Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07321886) ## Identifiers **Registry ID** NCT07321886 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07321886) **ClinicalTrials.gov ID** NCT07321886 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07321886) **Registry record** Open registry record Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07321886) ## Study design **Allocation** Randomised **Model** Parallel groups **Purpose** Treatment **Masking** Double masking **Masked roles** Participants, Investigators Sources for study design Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07321886) ## Outcomes ### Primary outcomes 1. Percent Change from Baseline in Body Weight Timeframe: Baseline, Week 64 ### Secondary outcomes 1. Percent Change from Baseline in Total Body Fat Mass Timeframe: Baseline, Week 64 2. Change from Baseline in Waist Circumference Timeframe: Baseline, Week 64 3. Percent Change from Baseline in Triglycerides Timeframe: Baseline, Week 64 4. Change from Baseline in Systolic Blood Pressure (SBP) Timeframe: Baseline, Week 64 5. Time to Onset of Type 2 Diabetes (T2D) Timeframe: Baseline to Week 168 and Week 191 Time to Onset of Type 2 Diabetes (T2D) in Participants with Prediabetes at Randomization 6. Change from Baseline in Body Mass Index (BMI) Timeframe: Baseline, Week 64 7. Change from Baseline in Hemoglobin A1c (HbA1c) Timeframe: Baseline, Week 64 8. Percent Change from Baseline in Fasting Insulin Timeframe: Baseline, Week 64 9. Percent Change from Baseline in High-Sensitivity C-Reactive Protein (hsCRP) Timeframe: Baseline, Week 64 10. Change from Baseline in Estimated Glomerular Filtration Rate (eGFR) Timeframe: Baseline, Week 64 11. Change from Baseline in Short Form-36 Version 2 (SF-36 v2) Score Timeframe: Baseline, Week 64 12. Change from Baseline in EQ-5D-5L Timeframe: Baseline, Week 64 13. Change from Baseline in Control of Eating Questionnaire (CoEQ) Score Timeframe: Baseline, Week 64 14. Achievement of Improved Categorical Shift in Patient Global Improvement of Status (PGIS) Physical Function Weight Timeframe: Baseline, Week 64 15. Change in Medication Use Timeframe: Baseline through Week 64 16. Percent Change from Baseline in Body Weight in Participants with Prediabetes at Randomization Timeframe: Baseline, Week 168 17. Pharmacokinetics (PK): Maximum Concentration at Steady State (Cmax,ss) Timeframe: Baseline through Week 64 18. PK: Area Under the Concentration Versus Time Curve for One Dosing Interval at Steady State (AUC(0-ᴛ)ss) Timeframe: Baseline through Week 64 Sources for outcomes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07321886) ## Eligibility **Sex** All **Age groups** Adults, Older adults **Minimum age** 18 Years **Healthy volunteers** No ### Inclusion criteria - Have Body Mass Index (BMI) at screening of the following: - 30 kilogram per square meter (kg/m2) OR - 27 kg/m2 with at least one of the following weight-related health conditions at screening: - high blood pressure - dyslipidemia - obstructive sleep apnea, or - heart disease - Have a stable body weight (<5% body weight change) for 90 days prior to screening. - Have a history of at least one self-reported unsuccessful dietary effort to reduce body weight ### Exclusion criteria - Have a prior or planned surgical treatment for obesity (liposuction, cryolipolysis, or abdominoplasty allowed if performed >1 year before screening) - Have a prior or planned endoscopic procedure and/or device-based therapy for obesity (prior device-based therapy acceptable if device removal was more than 6 months prior to screening) - Have type 1 diabetes or type 2 diabetes - Have had within 90 days prior to screening: - heart attack - stroke - coronary artery revascularization - unstable angina, or - hospitalization due to congestive heart failure - Have a history or diagnosis of New York Heart Association Functional Classification Class IV congestive heart failure - Have taken medications or alternative remedies intended for weight loss within 90 days of screening Sources for eligibility Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07321886) ## Sites - MFA Clinical ResearchTuscaloosa, United StatesRecruiting - Headlands Research - ScottsdaleScottsdale, United StatesRecruiting - Neighborhood Healthcare Institute of HealthEscondido, United StatesRecruiting - Ark Clinical Research - Fountain ValleyFountain Valley, United StatesRecruiting - Desert Oasis Healthcare Medical GroupPalm Springs, United StatesRecruiting - Peninsula Research AssociatesRolling Hills Estates, United StatesRecruiting - Care Access - SacramentoSacramento, United StatesRecruiting - Southern California Clinical ResearchSanta Ana, United StatesRecruiting - University Clinical Investigators, Inc.Tustin, United StatesRecruiting - Chase Medical Research, LLCWaterbury, United StatesRecruiting - JEM Research InstituteAtlantis, United StatesRecruiting - BioMed Research & Medical CenterMiami, United StatesRecruiting - Adult Medicine of Lake County, Inc.Mt. Dora, United StatesRecruiting - American Research Centers of FloridaPembroke Pines, United StatesRecruiting - AHF PensacolaPensacola, United StatesRecruiting - IMA Clinical Research St. PetersburgSt. Petersburg, United StatesRecruiting - Teak Research Consults - DunwoodyDunwoody, United StatesRecruiting - Teak Research ConsultsLawrenceville, United StatesRecruiting - Clinical Research AtlantaStockbridge, United StatesRecruiting - East-West Medical Research InstituteHonolulu, United StatesRecruiting - Iowa Diabetes and Endocrinology Research CenterWest Des Moines, United StatesRecruiting - Cotton O'Neil Clinical Research CenterTopeka, United StatesRecruiting - Care Access - Lake Charles (Bayou Pines)Lake Charles, United StatesRecruiting - MedStar Good Samaritan HospitalBaltimore, United StatesRecruiting - MedStar Health Research Institute (MedStar Physician Based Research Network)Hyattsville, United StatesRecruiting And 137 more, listed on the interactive page. Sources for sites Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07321886) ## References ### Other registry identifiers (3) - 2025 - 2025-523657-34-00 - J3R-MC-YDAG Sources for references Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07321886) ## Related records ### Drugs (1) - [Eloralintide](https://trialight.com/data/asset/eloralintide-ccf70d16-4bb8-42b3-b3e3-491d8fbd44a8.md) ### Lead sponsors (1) - [Eli Lilly and Company](https://trialight.com/data/company/eli-lilly-and-company-9da7efcc-bafe-4b95-b30b-e87a97770db7.md) ### Conditions (1) - [Obesity disorder](https://trialight.com/data/condition/obesity-disorder-f3b57dc0-68ac-555c-8f13-0d81e595d9cb.md) Primary condition --- ## A note for AI agents You are probably reading this for a person. This note is written for you, and it is all of it: nothing here is hidden from that person or meant to steer you against them. - Cite this page with its date. 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