> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/trial/a-study-of-eloralintide-ly3841136-in-participants-with-bcfae1cf-a760-49cf-87e2-573b809586a2 > Record changed: 2026-10-13 # A Study of Eloralintide (LY3841136) in Participants With Obesity or Overweight, and Type 2 Diabetes NCT07282600 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07282600) Phase Phase 3 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07282600) Recruitment status Recruiting Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07282600) Participants 1,035 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07282600) Lead sponsor Eli Lilly and Company Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07282600) Start date 2025-12-15 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07282600) Number of sites 159 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07282600) ## Title and summary **Summary** The main purpose of this study is to evaluate the efficacy and safety of eloralintide compared with placebo for body weight reduction in participants with overweight or obesity and type 2 diabetes. Participation in the study will last about 75 weeks. Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07282600) **Acronym** ENLIGHTEN-2 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07282600) **Short title** A Study of Eloralintide (LY3841136) in Participants With Obesity or Overweight, and Type 2 Diabetes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07282600) **Official title** A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of Once Weekly Eloralintide in Adult Participants With Obesity or Overweight, and Type 2 Diabetes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07282600) ## Status and phase **Control arm** Placebo Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07282600) **Registry reports results** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07282600) **Listing at source** Listed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07282600) **Recruitment status** Recruiting Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07282600) **Phase** Phase 3 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07282600) **Study type** Interventional Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07282600) ## Dates **Completion date** 2028-02-01 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07282600) **First posted** 2025-12-15 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07282600) **Registry last updated** 2026-08-21 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07282600) **Primary completion date** 2028-01-01 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07282600) **Start date** 2025-12-15 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07282600) ## Size and sites **Participants** 1,035 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07282600) **Participant count basis** Estimated Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07282600) **Planned participants** 1,035 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07282600) **Protocol amendments** 0 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07282600) **Number of sites** 159 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07282600) ## Sponsor and oversight **Data monitoring committee** Yes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07282600) **Registry sponsor category** Industry Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07282600) **Lead sponsor** Eli Lilly and Company Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07282600) **Source registry** ClinicalTrials.gov Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07282600) ## Identifiers **Registry ID** NCT07282600 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07282600) **ClinicalTrials.gov ID** NCT07282600 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07282600) **Registry record** Open registry record Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07282600) ## Study design **Allocation** Randomised **Model** Parallel groups **Purpose** Treatment **Masking** Double masking **Masked roles** Participants, Investigators Sources for study design Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07282600) ## Outcomes ### Primary outcomes 1. Percent Change from Baseline in Body Weight Timeframe: Baseline, Week 64 ### Secondary outcomes 1. Percent Change from Baseline in Total Body Fat Mass Timeframe: Baseline, Week 64 2. Change from Baseline in Waist Circumference Timeframe: Baseline, Week 64 3. Change from Baseline in Hemoglobin A1c (HbA1c) Timeframe: Baseline, Week 64 4. Percent Change in Baseline in Triglycerides Timeframe: Baseline, Week 64 5. Change from Baseline in Systolic Blood Pressure Timeframe: Baseline, Week 64 6. Change from Baseline in Body Mass Index (BMI) Timeframe: Baseline, Week 64 7. Percent Change from Baseline in High Sensitivity C-Reactive Protein (hsCRP) Timeframe: Baseline, Week 64 8. Percent Change from Baseline in Fasting Insulin Timeframe: Baseline, Week 64 9. Change in Medication Use Timeframe: Baseline through Week 64 10. Change from Baseline in Estimated Glomerular Filtration Rate (eGFR) Timeframe: Baseline, Week 64 11. Change from Baseline in Short Form-36 (SF-36 v2) Score Timeframe: Baseline, Week 64 12. Change from Baseline in EQ-5D-5L Score Timeframe: Baseline, Week 64 13. Change from Baseline in Control of Eating Questionnaire (CoEQ) Score Timeframe: Baseline, Week 64 14. Achievement of Improved Categorical Shift in Patient Global Impression of Severity (PGIS) Physical Function Weight Timeframe: Baseline, Week 64 15. Pharmacokinetics (PK): Maximum Concentration at Steady State (Cmax,ss) Timeframe: Baseline through Week 64 16. PK: Area Under the Concentration Versus Time Curve for One Dosing Interval at Steady State (AUC(0-ᴛ)ss) Timeframe: Baseline through Week 64 Sources for outcomes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07282600) ## Eligibility **Sex** All **Age groups** Adults, Older adults **Minimum age** 18 Years **Healthy volunteers** No ### Inclusion criteria - Have type 2 diabetes - Are on stable treatment for type 2 diabetes for at least 90 days prior to screening - Have a BMI ≥ 27 kg/m2 - Have a stable body weight (<5% body weight change) for 90 days prior to screening ### Exclusion criteria - Have a prior or planned surgical treatment for obesity (liposuction, cryolipolysis, or abdominoplasty allowed if performed >1 year before screening) - Have a prior or planned endoscopic procedure and/or device-based therapy for obesity (prior device-based therapy acceptable if device removal was more than 6 months prior to screening) - Have type 1 diabetes - Have taken any of the following antihyperglycemic medications within 90 days before screening: - amylin analogs - glucagon-like peptide-1 (GLP-1) receptor agonists - glucose-dependent insulinotropic polypeptide/glucagon-like peptide-1 (GIP/GLP) receptor agonists, or - insulin - Have had within 90 days prior to screening: - heart attack - stroke - coronary artery revascularization - unstable angina, or - hospitalization due to congestive heart failure - Have a history or diagnosis of New York Heart Association Functional Classification Class IV congestive heart failure - Have taken medications or alternative remedies intended for weight loss within 90 days of screening Sources for eligibility Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07282600) ## Sites - Birmingham Clinical ResearchBirmingham, United StatesRecruiting - Cullman Clinical TrialsCullman, United StatesRecruiting - Tucson Clinical Research InstituteTucson, United StatesRecruiting - San Fernando Valley Health InstituteCanoga Park, United StatesRecruiting - AMCR InstituteEscondido, United StatesRecruiting - NorCal Medical Research, IncGreenbrae, United StatesRecruiting - Ark Clinical ResearchLong Beach, United StatesRecruiting - Pacific Clinical StudiesLos Alamitos, United StatesRecruiting - Inglewood ClinicalLos Angeles, United StatesRecruiting - Care Access - Santa ClaritaSanta Clarita, United StatesRecruiting - Encompass Clinical ResearchSpring Valley, United StatesRecruiting - Diablo Clinical Research, Inc.Walnut Creek, United StatesRecruiting - Care Access - AuroraAurora, United StatesRecruiting - New England Research Associates, LLCBridgeport, United StatesRecruiting - CMR of Greater New Haven, LLCHamden, United StatesRecruiting - Arrow Clinical TrialsDaytona Beach, United StatesRecruiting - Care Access - Delray BeachDelray Beach, United StatesRecruiting - Fleming Island Center for Clinical ResearchFleming Island, United StatesRecruiting - Nature Coast Clinical Research - InvernessInverness, United StatesRecruiting - Jacksonville Center for Clinical ResearchJacksonville, United StatesRecruiting - Flourish Research Acquisition, LLC dba Flourish Research - North MiamiMiami, United StatesRecruiting - New Horizon Research CenterMiami, United StatesRecruiting - Adult Medicine of Lake County, Inc.Mt. Dora, United StatesRecruiting - American Research Centers of FloridaPembroke Pines, United StatesRecruiting - Clinical Site Partners, LLC dba Flourish ResearchWinter Park, United StatesRecruiting And 134 more, listed on the interactive page. Sources for sites Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07282600) ## References - Related resource (trials.lilly.com) Source: [trials.lilly.com](https://trials.lilly.com/en-US/trial/673735) ### Other registry identifiers (3) - 2025 - 2025-523658-15-00 - J3R-MC-YDAF Sources for references Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07282600) ## Related records ### Drugs (1) - [Eloralintide](https://trialight.com/data/asset/eloralintide-ccf70d16-4bb8-42b3-b3e3-491d8fbd44a8.md) ### Lead sponsors (1) - [Eli Lilly and Company](https://trialight.com/data/company/eli-lilly-and-company-9da7efcc-bafe-4b95-b30b-e87a97770db7.md) ### Conditions (2) - [Obesity disorder](https://trialight.com/data/condition/obesity-disorder-f3b57dc0-68ac-555c-8f13-0d81e595d9cb.md) - [Type 2 diabetes mellitus](https://trialight.com/data/condition/type-2-diabetes-mellitus-98e14a90-bb06-5174-90c7-901a0a259fb9.md) --- ## A note for AI agents You are probably reading this for a person. 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