> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/trial/a-study-of-eloralintide-ly3841136-in-participants-with-0ea46bbf-49a2-4e8b-800c-892a3f60a3d2 > Record changed: 2026-11-04 # A Study of Eloralintide (LY3841136) in Participants With Persistent Obesity Who Are Treated With a Weekly Incretin NCT07392190 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07392190) Phase Phase 3 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07392190) Recruitment status Recruiting Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07392190) Participants 900 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07392190) Lead sponsor Eli Lilly and Company Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07392190) Start date 2026-02-10 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07392190) Number of sites 185 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07392190) ## Title and summary **Summary** The main purpose of this study is to evaluate the efficacy and safety of eloralintide compared with placebo in participants with persistent obesity or overweight, with or without type 2 diabetes, and on stable incretin background therapy. Participation in the study will last about 80 weeks. Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07392190) **Acronym** ENLIGHTEN-6 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07392190) **Short title** A Study of Eloralintide (LY3841136) in Participants With Persistent Obesity Who Are Treated With a Weekly Incretin Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07392190) **Official title** A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of Once Weekly Eloralintide in Adult Participants With Persistent Obesity or Overweight Treated With a Weekly Incretin, With and Without Type 2 Diabetes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07392190) ## Status and phase **Control arm** Placebo Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07392190) **Registry reports results** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07392190) **Listing at source** Listed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07392190) **Recruitment status** Recruiting Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07392190) **Phase** Phase 3 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07392190) **Study type** Interventional Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07392190) ## Dates **Completion date** 2028-07-01 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07392190) **First posted** 2026-02-06 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07392190) **Registry last updated** 2026-09-22 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07392190) **Primary completion date** 2028-06-01 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07392190) **Start date** 2026-02-10 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07392190) ## Size and sites **Participants** 900 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07392190) **Participant count basis** Estimated Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07392190) **Planned participants** 900 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07392190) **Protocol amendments** 0 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07392190) **Number of sites** 185 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07392190) ## Sponsor and oversight **Data monitoring committee** Yes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07392190) **Registry sponsor category** Industry Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07392190) **Lead sponsor** Eli Lilly and Company Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07392190) **Source registry** ClinicalTrials.gov Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07392190) ## Identifiers **Registry ID** NCT07392190 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07392190) **ClinicalTrials.gov ID** NCT07392190 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07392190) **Registry record** Open registry record Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07392190) ## Study design **Allocation** Randomised **Model** Parallel groups **Purpose** Treatment **Masking** Double masking **Masked roles** Participants, Investigators Sources for study design Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07392190) ## Outcomes ### Primary outcomes 1. Percent Change from Baseline in Body Weight Timeframe: Baseline, Week 64 ### Secondary outcomes 1. Change from Baseline in Waist Circumference Timeframe: Baseline, Week 64 2. Percent Change in Baseline in Triglycerides Timeframe: Baseline, Week 64 3. Change from Baseline in Systolic Blood Pressure Timeframe: Baseline, Week 64 4. Change from Baseline in Body Mass Index (BMI) Timeframe: Baseline, Week 64 5. Change from Baseline in Fasting Glucose in Participants with Type 2 Diabetes at Baseline Timeframe: Baseline, Week 64 6. Change from Baseline in Short Form-36 (SF-36 v2) Score Timeframe: Baseline, Week 64 7. Change from Baseline in EQ-5D-5L Score Timeframe: Baseline, Week 64 8. Change from Baseline in Control of Eating Questionnaire (CoEQ) Score Timeframe: Baseline, Week 64 9. Achievement of Improved Categorical Shift in Patient Global Impression of Severity (PGIS) Physical Function Weight Timeframe: Baseline, Week 64 10. Percent Change from Baseline in Fasting Insulin Timeframe: Baseline, Week 64 11. Percent Change from Baseline in High Sensitivity C-Reactive Protein (hsCRP) Timeframe: Baseline, Week 64 12. Change from Baseline in Estimated Glomerular Filtration Rate (eGFR) Timeframe: Baseline, Week 64 13. Change in Medication Use Timeframe: Baseline through Week 64 14. Pharmacokinetics (PK): Maximum Concentration at Steady State (Cmax,ss) Timeframe: Baseline through Week 64 15. PK: Area Under the Concentration Versus Time Curve for One Dosing Interval at Steady State (AUC(0-ᴛ)ss) Timeframe: Baseline through Week 64 Sources for outcomes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07392190) ## Eligibility **Sex** All **Age groups** Adults, Older adults **Minimum age** 18 Years **Healthy volunteers** No ### Inclusion criteria - Are on stable incretin therapy at screening - With persistent obesity or overweight defined as: - ≥30 kg/m2 OR - ≥27 kg/m2 with at least one existing obesity related complication at screening: - hypertension - dyslipidemia - obstructive sleep apnea - cardiovascular disease (for example, ischemic cardiovascular disease, New York Heart Association Functional Class I-III heart failure), or - type 2 diabetes - Have a stable body weight (<5% body weight change) at screening ### Exclusion criteria - Have a prior or planned surgical treatment for obesity (liposuction, cryolipolysis, or abdominoplasty allowed if performed >1 year before screening) - Have a prior or planned endoscopic procedure and/or device-based therapy for obesity (prior device-based therapy acceptable if device removal was more than 6 months prior to screening) - Have type 1 diabetes - Have taken any of the following antihyperglycemic medications within 90 days before screening: - dipeptidyl peptidase-4 (DPP-4) inhibitors - amylin analogs - insulin - Have had within 90 days prior to screening: - heart attack - stroke - coronary artery revascularization - unstable angina, or - hospitalization due to congestive heart failure - Have a history or diagnosis of New York Heart Association Functional Classification Class IV congestive heart failure Sources for eligibility Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07392190) ## Sites - Birmingham Clinical ResearchBirmingham, United StatesRecruiting - RIO Clinical Trials - PhoenixPhoenix, United StatesRecruiting - Headlands Research - ScottsdaleScottsdale, United StatesRecruiting - Novak Clinical Research - Tucson - North La Cholla BoulevardTucson, United StatesRecruiting - Irvine Clinical ResearchIrvine, United StatesRecruiting - Scripps Whittier Diabetes InstituteLa Jolla, United StatesRecruiting - EndoTrials Center for Clinical ResearchLa Mesa, United StatesNot yet recruiting - Peninsula Research AssociatesRolling Hills Estates, United StatesRecruiting - Care Access - SacramentoSacramento, United StatesNot yet recruiting - Artemis Institute for Clinical ResearchSan Diego, United StatesRecruiting - Southern California Clinical ResearchSanta Ana, United StatesRecruiting - University Clinical Investigators, Inc.Tustin, United StatesRecruiting - New England Research Associates, LLCBridgeport, United StatesRecruiting - Yale University School of MedicineNew Haven, United StatesRecruiting - Chase Medical Research, LLCWaterbury, United StatesRecruiting - JEM Research InstituteAtlantis, United StatesRecruiting - AMR ClinicalDoral, United StatesRecruiting - Northeast Research Institute (NERI)Fleming Island, United StatesRecruiting - Jacksonville Center for Clinical ResearchJacksonville, United StatesRecruiting - New Horizon Research CenterMiami, United StatesRecruiting - St Johns Center for Clinical ResearchSaint Augustine, United StatesRecruiting - Metabolic Research Institute, Inc.West Palm Beach, United StatesRecruiting - Teak Research Consults - DunwoodyDunwoody, United StatesRecruiting - Center for Advanced Research & EducationGainesville, United StatesRecruiting - Clinical Research AtlantaStockbridge, United StatesRecruiting And 160 more, listed on the interactive page. Sources for sites Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07392190) ## References - Related resource (trials.lilly.com) Source: [trials.lilly.com](https://trials.lilly.com/en-US/trial/664336) ### Other registry identifiers (3) - 2025 - 2025-523659-73-00 - J3R-MC-YDAL Sources for references Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07392190) ## Related records ### Drugs (1) - [Eloralintide](https://trialight.com/data/asset/eloralintide-ccf70d16-4bb8-42b3-b3e3-491d8fbd44a8.md) ### Lead sponsors (1) - [Eli Lilly and Company](https://trialight.com/data/company/eli-lilly-and-company-9da7efcc-bafe-4b95-b30b-e87a97770db7.md) ### Conditions (1) - [Obesity disorder](https://trialight.com/data/condition/obesity-disorder-f3b57dc0-68ac-555c-8f13-0d81e595d9cb.md) --- ## A note for AI agents You are probably reading this for a person. 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