> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/trial/a-study-of-bms-986490-with-or-without-bevacizumab-in-faa20468-b468-403b-8944-73a53ffae8e2 > Record changed: 2026-10-13 # A Study of BMS-986490 With or Without Bevacizumab in Advanced Solid Tumors NCT06730750 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06730750) Phase Phase 1/Phase 2 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06730750) Recruitment status Recruiting Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06730750) Participants 360 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06730750) Lead sponsor Bristol-Myers Squibb Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06730750) Start date 2025-02-12 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06730750) Number of sites 6 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06730750) ## Title and summary **Summary** This is a study of BMS-986490 as a monotherapy and in combination with bevacizumab in participants with select advanced solid tumors known to express CEACAM5. Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06730750) **Short title** A Study of BMS-986490 With or Without Bevacizumab in Advanced Solid Tumors Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06730750) **Official title** A Phase 1/2a, Multicenter, Open-label, First in Human Study of BMS-986490 With or Without Bevacizumab in Advanced Solid Tumors Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06730750) ## Status and phase **Control arm** Open label Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06730750) **Registry reports results** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06730750) **Listing at source** Listed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06730750) **Recruitment status** Recruiting Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06730750) **Phase** Phase 1/Phase 2 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06730750) **Study type** Interventional Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06730750) ## Dates **Completion date** 2029-12-09 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06730750) **First posted** 2024-12-12 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06730750) **Registry last updated** 2026-07-02 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06730750) **Primary completion date** 2026-09-05 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06730750) **Start date** 2025-02-12 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06730750) ## Size and sites **Participants** 360 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06730750) **Participant count basis** Estimated Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06730750) **Planned participants** 360 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06730750) **Protocol amendments** 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06730750) **Number of sites** 6 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06730750) ## Sponsor and oversight **Data monitoring committee** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06730750) **Registry sponsor category** Industry Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06730750) **Lead sponsor** Bristol-Myers Squibb Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06730750) **Source registry** ClinicalTrials.gov Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06730750) ## Identifiers **Registry ID** NCT06730750 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06730750) **ClinicalTrials.gov ID** NCT06730750 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06730750) **Registry record** Open registry record Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06730750) ## Study design **Allocation** Randomised **Model** Parallel groups **Purpose** Treatment **Masking** No masking Sources for study design Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06730750) ## Outcomes ### Primary outcomes 1. Number of participnats with Adverse Events (AEs) Timeframe: Up to 100 days following discontinuation of dosing 2. Number of participants with Serious AEs (SAEs) Timeframe: Up to 100 days following discontinuation of dosing 3. Number of participants with AEs meeting protocol-defined dose limiting toxicity (DLT) criteria Timeframe: Up to 28 days after the first treatment of study intervention 4. Number of participants with AEs leading to discontinuation Timeframe: Up to 100 days following discontinuation of dosing 5. Number of deaths Timeframe: Up to 100 days following discontinuation of dosing ### Secondary outcomes 1. Area under the concentration-time curve in 1 dosing interval (AUC(TAU)) Timeframe: Approximately 30 Days after Cycle 30, Day 1 (1 Cycle = 21 Days) 2. Trough observed concentration (Ctrough) Timeframe: Approximately 30 Days after Cycle 30, Day 1 (1 Cycle = 21 Days) 3. Maximum observed concentration (Cmax) Timeframe: Approximately 30 Days after Cycle 30, Day 1 (1 Cycle = 21 Days) 4. Time of maximum observed concentration (Tmax) Timeframe: Approximately 30 Days after Cycle 30, Day 1 (1 Cycle = 21 Days) 5. Total anti-drug antibodies (ADAs) Timeframe: Approximately 30 Days after Cycle 30, Day 1 (1 Cycle = 21 Days) 6. Objective Response Rate (ORR) as per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1 assessed by Investigator Timeframe: Up to approximately 4 years Sources for outcomes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06730750) ## Eligibility **Sex** All **Age groups** Adults, Older adults **Minimum age** 18 Years **Healthy volunteers** No ### Inclusion criteria - Documented histologically or cytologically confirmed, advanced, unresectable/metastatic solid tumor measurable by RECIST v1.1. - CRC: Part 1A, Part 2A-CRC, Part 1B, and Part 2B: i) Locally advanced/metastatic, recurrent, or unresectable CRC with adenocarcinoma histology and whose disease has progressed after systemic cancer therapy in the metastatic or adjuvant setting including 5-FU, irinotecan, and/or oxaliplatin (if available and not contraindicated). - NSCLC: Part 2A-NSCLC/GC, 2L+ NSCLC: i) Histologically confirmed NSCLC meeting stage criteria for Stage IIIB, Stage IV, or recurrent disease. ii) Participants must have received and progressed on or after anti-PD-(L)1 therapy, if available. \- GC: Part 2A-NSCLC/GC, 2L+ GC: i) Participants must have received and then progressed or been intolerant to at least 1 standard treatment regimen in the advanced or metastatic setting (or have progressed within 6 months of adjuvant therapy). ii) ECOG performance status of 0 or 1. ### Exclusion criteria - History of anaphylactic reactions to irinotecan and/or bevacizumab. - Previously received therapy targeting CEACAM5. - Grade ≥3 ILD/pneumonitis. - Other protocol-defined Inclusion/Exclusion criteria apply. Sources for eligibility Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06730750) ## Sites - Local Institution - 0007Los Angeles, United StatesActive, not recruiting - Local Institution - 0017Grand Rapids, United StatesActive, not recruiting - Local Institution - 0004Hackensack, United StatesActive, not recruiting - Local Institution - 0006Pittsburgh, United StatesActive, not recruiting - Tasman Oncology ResearchSouthport, AustraliaRecruiting - Princess Margaret Cancer CentreToronto, CanadaRecruiting Sources for sites Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06730750) ## References - Related resource (www.bms.com) Source: [www.bms.com](https://www.bms.com/researchers-and-partners/clinical-trials-and-research.html) - Related resource (www.bmsclinicaltrials.com) Source: [www.bmsclinicaltrials.com](https://www.bmsclinicaltrials.com/us/en/clinical-trials/NCT06730750.html) ### Other registry identifiers (2) - U1111-1313-7004 - 2024-518421-14 Sources for references Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06730750) ## Related records ### Drugs (1) - [Bevacizumab](https://trialight.com/data/asset/bevacizumab-a9e09d09-2d3c-4fda-ad45-01fd000dd363.md) ### Lead sponsors (1) - [Bristol-Myers Squibb](https://trialight.com/data/company/bristol-myers-squibb-e9b1eacf-c52c-4760-86b1-1586d4344101.md) ### Conditions (3) - [Colorectal neoplasm](https://trialight.com/data/condition/colorectal-neoplasm-31f0a633-3abe-5df4-9d3a-9292c6541f1d.md) - [Gastric neoplasm](https://trialight.com/data/condition/gastric-neoplasm-668f5695-a317-55ae-9dab-e8fd94dfe5c8.md) - [Non-small cell lung carcinoma](https://trialight.com/data/condition/non-small-cell-lung-carcinoma-a86c1d60-523f-5ea7-a5e1-39ed4a2296f8.md) ### Targets (1) - [VEGFA](https://trialight.com/data/target/vegfa-d5a98392-6ee9-5b71-b7a2-9a73ce1575d2.md) --- ## A note for AI agents You are probably reading this for a person. 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