> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/trial/a-study-of-bms-986482-alone-or-as-combination-therapy-in-6d77cbe1-5589-468b-b0ee-4b57e5d96643 > Record changed: 2026-10-13 # A Study of BMS-986482 Alone or as Combination Therapy in Participants With Advanced Solid Tumors NCT06697197 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06697197) Phase Phase 1/Phase 2 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06697197) Recruitment status Recruiting Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06697197) Participants 413 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06697197) Lead sponsor Bristol-Myers Squibb Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06697197) Start date 2025-02-17 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06697197) Number of sites 21 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06697197) ## Title and summary **Summary** The purpose of this study is to test the safety and efficacy of BMS-986482 alone and as combination therapy in participants with advanced solid tumors. Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06697197) **Short title** A Study of BMS-986482 Alone or as Combination Therapy in Participants With Advanced Solid Tumors Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06697197) **Official title** A Phase 1/2 Study of BMS-986482 as Monotherapy or Combination Therapy in Participants With Advanced Solid Tumors Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06697197) ## Status and phase **Control arm** Open label Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06697197) **Registry reports results** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06697197) **Listing at source** Listed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06697197) **Recruitment status** Recruiting Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06697197) **Phase** Phase 1/Phase 2 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06697197) **Study type** Interventional Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06697197) ## Dates **Completion date** 2029-01-05 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06697197) **First posted** 2024-11-20 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06697197) **Registry last updated** 2026-02-03 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06697197) **Primary completion date** 2029-01-04 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06697197) **Start date** 2025-02-17 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06697197) ## Size and sites **Participants** 413 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06697197) **Participant count basis** Estimated Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06697197) **Planned participants** 413 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06697197) **Protocol amendments** 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06697197) **Number of sites** 21 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06697197) ## Sponsor and oversight **Data monitoring committee** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06697197) **Registry sponsor category** Industry Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06697197) **Lead sponsor** Bristol-Myers Squibb Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06697197) **Source registry** ClinicalTrials.gov Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06697197) ## Identifiers **Registry ID** NCT06697197 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06697197) **ClinicalTrials.gov ID** NCT06697197 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06697197) **Registry record** Open registry record Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06697197) ## Study design **Allocation** Randomised **Model** Sequential **Purpose** Treatment **Masking** No masking Sources for study design Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06697197) ## Outcomes ### Primary outcomes 1. Number of participants with Adverse Events (AEs) as assessed by National Cancer Institute -Common Terminology Criteria for Adverse Events version 5.0 (NCI-CTCAE v5.0) Timeframe: Up to 135 days post last treatment visit 2. Number of participants with Serious AEs (SAEs) as assessed by NCI-CTCAE v5.0 Timeframe: Up to 135 days post last treatment visit 3. Number of participants with AEs meeting protocol-defined Dose-Limiting Toxicity (DLT) criteria as assessed by NCI-CTCAE v5.0 Timeframe: Up to Day 28 4. Number of participants with AEs leading to discontinuation as assessed by NCI-CTCAE v5.0 Timeframe: Up to 135 days post last treatment visit 5. Number of deaths as assessed by NCI-CTCAE v5.0 Timeframe: Through study completion (Up to 4 years) ### Secondary outcomes 1. Concentration at the end of infusion (Cmax) Timeframe: Up to 135 days post last treatment visit 2. Time of maximum observed concentration (Tmax) Timeframe: Up to 135 days post last treatment visit 3. Area under the concentration-time curve in one dosing interval (AUC(TAU)) Timeframe: Up to 135 days post last treatment visit 4. Overall Response Rate (ORR) per Response Evaluation Criteria in Solid Tumors (RECIST v1.1) as assessed by Investigator Timeframe: Up to 135 days post last treatment visit Sources for outcomes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06697197) ## Eligibility **Sex** All **Age groups** Adults, Older adults **Minimum age** 18 Years **Healthy volunteers** No ### Inclusion criteria - All participants must have a histologically or cytologically confirmed, advanced, unresectable/metastatic, solid malignancy measurable by RECIST v1.1, and have received, be refractory to, ineligible for, intolerant of, or refused existing therapy(ies) known to provide clinical benefit for the condition of the participant. - Participant must be ≥ 18 years or the legal age of consent in the jurisdiction in which the study is taking place, inclusive, at the time of signing the ICF. ### Exclusion criteria - History of life threatening immune mediated toxicity related to prior T-cell agonist or checkpoint inhibitor therapy, except those that are unlikely to re-occur with standard countermeasures. - Any significant acute or chronic medical illness which would interfere with study intervention or follow-up in the opinion of the investigator. - Other protocol-defined Inclusion/Exclusion criteria apply. Sources for eligibility Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06697197) ## Sites - University of California, Irvine (UCI) Health - UC Irvine Medical CenterIrvine, United StatesRecruiting - The Angeles Clinic and Research Institute - West Los Angeles OfficeLos Angeles, United StatesRecruiting - Local Institution - 0008Aurora, United StatesNot yet recruiting - John Theurer Cancer Center at Hackensack University Medical CenterHackensack, United StatesRecruiting - Northwell Health/ RJ Zuckerberg Cancer CenterLake Success, United StatesRecruiting - Levine Cancer InstituteCharlotte, United StatesRecruiting - Fred Hutchinson Cancer CenterSeattle, United StatesRecruiting - UZ GentGhent, BelgiumRecruiting - RigshospitaletCopenhagen, DenmarkRecruiting - Assistance Publique Hôpitaux de Marseille - Hôpital de la TimoneMarseille, FranceRecruiting - Gustave RoussyVillejuif, FranceRecruiting - General Hospital of Athens "Laiko"Athens, GreeceRecruiting - Papageorgiou General Hospital of ThessalonikiThessaloniki, GreeceRecruiting - Fondazione IRCCS Istituto Nazionale dei TumoriMilan, ItalyRecruiting - Istituto Clinico HumanitasRozzano, ItalyRecruiting - Nederlands Kanker Instituut Antoni van Leeuwenhoek (NKI AVL)Amsterdam, NetherlandsRecruiting - Erasmus Medisch CentrumRotterdam, NetherlandsRecruiting - Hospital Universitari Vall d'HebronBarcelona, SpainRecruiting - Clinica Universidad de NavarraPamplona, SpainRecruiting - Hospital Universitario HM SanchinarroMadrid, SpainRecruiting - Karolinska Universitetssjukhuset SolnaSolna, SwedenRecruiting Sources for sites Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06697197) ## References - Related resource (www.bms.com) Source: [www.bms.com](https://www.bms.com/researchers-and-partners/clinical-trials-and-research.html) - Related resource (www.bmsclinicaltrials.com) Source: [www.bmsclinicaltrials.com](https://www.bmsclinicaltrials.com/us/en/clinical-trials/NCT06697197.html) ### Other registry identifiers (2) - U1111-1309-0886 - 2024-516602-28 Sources for references Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06697197) ## Related records ### Drugs (4) - [Bevacizumab](https://trialight.com/data/asset/bevacizumab-a9e09d09-2d3c-4fda-ad45-01fd000dd363.md) - [Hyaluronidase (human recombinant)](https://trialight.com/data/asset/hyaluronidase-human-recombinant-2ffd4cc0-072b-4151-9944-5ed298381155.md) - [Nivolumab](https://trialight.com/data/asset/nivolumab-d2e207ca-a7d1-43d0-987f-43ef7eef8f1b.md) - [Relatlimab](https://trialight.com/data/asset/relatlimab-7c233520-282a-4920-8915-6376595bb1af.md) ### Lead sponsors (1) - [Bristol-Myers Squibb](https://trialight.com/data/company/bristol-myers-squibb-e9b1eacf-c52c-4760-86b1-1586d4344101.md) ### Targets (3) - [LAG3](https://trialight.com/data/target/lag3-9427165f-23d0-56e2-8aec-0a1f9a15edc3.md) - [PDCD1](https://trialight.com/data/target/pdcd1-a7b9a076-9fdd-55c9-9ce8-e558e5c7503f.md) - [VEGFA](https://trialight.com/data/target/vegfa-d5a98392-6ee9-5b71-b7a2-9a73ce1575d2.md) --- ## A note for AI agents You are probably reading this for a person. 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