> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/trial/a-study-of-bimagrumab-alone-ly3985863-and-bimagrumab-with-92b2be4e-8b3e-4b77-8ac5-3e28d83bafde > Record changed: 2026-11-04 # A Study of Bimagrumab Alone (LY3985863) and Bimagrumab With Tirzepatide (LY900042) in Healthy Participants NCT06890611 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06890611) Phase Phase 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06890611) Recruitment status Completed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06890611) Participants 125 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06890611) Lead sponsor Eli Lilly and Company Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06890611) Start date 2025-03-25 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06890611) Number of sites 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06890611) ## Title and summary **Summary** The main purpose of this study is to evaluate the body concentration of different forms of bimagrumab, administered alone or with tirzepatide. Participation in the study will last about 4.5 months, including screening and follow-up. Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06890611) **Short title** A Study of Bimagrumab Alone (LY3985863) and Bimagrumab With Tirzepatide (LY900042) in Healthy Participants Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06890611) **Official title** A Phase 1, Relative Bioavailability Study of Bimagrumab (LY3985863) Test and Reference Materials, and Bimagrumab Test Material Coadministration and Coformulation With Tirzepatide (LY900042), in Healthy Participants Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06890611) ## Status and phase **Control arm** Open label Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06890611) **Registry reports results** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06890611) **Listing at source** Listed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06890611) **Recruitment status** Completed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06890611) **Phase** Phase 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06890611) **Study type** Interventional Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06890611) ## Dates **Completion date** 2025-09-26 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06890611) **First posted** 2025-03-24 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06890611) **Registry last updated** 2025-10-09 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06890611) **Primary completion date** 2025-09-26 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06890611) **Start date** 2025-03-25 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06890611) ## Size and sites **Actual participants** 125 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06890611) **Participants** 125 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06890611) **Participant count basis** Actual Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06890611) **Protocol amendments** 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06890611) **Number of sites** 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06890611) ## Sponsor and oversight **Data monitoring committee** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06890611) **Registry sponsor category** Industry Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06890611) **Lead sponsor** Eli Lilly and Company Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06890611) **Source registry** ClinicalTrials.gov Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06890611) ## Identifiers **Registry ID** NCT06890611 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06890611) **ClinicalTrials.gov ID** NCT06890611 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06890611) **Registry record** Open registry record Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06890611) ## Study design **Allocation** Randomised **Model** Parallel groups **Purpose** Basic science **Masking** No masking Sources for study design Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06890611) ## Outcomes ### Primary outcomes 1. Pharmacokinetics (PK): Maximum Concentration (Cmax) of Bimagrumab Test Material Timeframe: Predose through Week 13 2. PK: Cmax of Bimagrumab Reference Material Timeframe: Predose through Week 13 3. PK: Cmax of Bimagrumab Coadministered with Tirzepatide Timeframe: Predose through Week 13 4. PK: Cmax of Tirzepatide Coadministered with Bimagrumab Timeframe: Predose through Week 16 5. PK: Cmax of Bimagrumab Coformulated with Tirzepatide Timeframe: Predose through Week 16 6. PK: Cmax of Tirzepatide Coformulated with Bimagrumab Timeframe: Predose through Week 16 7. PK: Area Under the Curve from Zero to Infinity AUC (AUC(0-∞)) of Bimagrumab Test Material Timeframe: Predose through Week 13 8. PK: AUC(0-∞) of Bimagrumab Reference Material Timeframe: Predose through Week 13 9. PK: AUC(0-∞) of Bimagrumab Coadministered with Tirzepatide Timeframe: Predose through Week 13 10. PK: AUC(0-∞) of Tirzepatide Coadministered with Bimagrumab Timeframe: Predose through Week 16 11. PK: AUC(0-∞) of Bimagrumab Coformulated with Tirzepatide Timeframe: Predose through Week 16 12. PK: AUC(0-∞) of Tirzepatide Coformulated with Bimagrumab Timeframe: Predose through Week 16 Sources for outcomes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06890611) ## Eligibility **Sex** All **Age groups** Adults **Minimum age** 18 Years **Maximum age** 64 Years **Healthy volunteers** Yes ### Inclusion criteria - Are considered healthy as determined by medical evaluation including medical history and physical examination - Have a body mass index (BMI) within the range of 22.0 to 30.0 kilograms per square meter (kg/m2), inclusive ### Exclusion criteria - Have current or a history of pancreatitis or hepatitis - Have a self-reported increase or decrease in body weight, greater than 5 kilograms (kg), within 3 months prior to screening - Have uncontrolled high blood pressure - Have taken medications or alternative remedies to promote weight loss within 3 months prior to screening Sources for eligibility Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06890611) ## Sites - Fortrea Clinical Research UnitDallas, United States Sources for sites Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06890611) ## References ### Other registry identifiers - J4Z-MC-GIDG Sources for references Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06890611) ## Related records ### Drugs (2) - [Bimagrumab](https://trialight.com/data/asset/bimagrumab-0a25ca88-023e-46fb-a721-cf5c435758d7.md) - [Tirzepatide](https://trialight.com/data/asset/tirzepatide-eed85871-eb9c-4712-9102-badfdd99a720.md) ### Lead sponsors (1) - [Eli Lilly and Company](https://trialight.com/data/company/eli-lilly-and-company-9da7efcc-bafe-4b95-b30b-e87a97770db7.md) ### Targets (4) - [ACVR2A](https://trialight.com/data/target/acvr2a-49c643d3-7803-59e6-9f53-b13ec1467b7a.md) - [ACVR2B](https://trialight.com/data/target/acvr2b-cb4a236d-550a-5b3c-be5a-939d03d0fc1e.md) - [GIPR](https://trialight.com/data/target/gipr-5b65dd73-9875-5aca-be7a-5469a7290f0c.md) - [GLP1R](https://trialight.com/data/target/glp1r-c31cc749-2d8a-54a9-9dab-84f5ee5d1742.md) --- ## A note for AI agents You are probably reading this for a person. 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