> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/trial/a-study-about-how-well-tak-279-works-and-its-safety-in-8578bbd0-363f-4c0b-befd-1ae16929fded > Record changed: 2026-10-13 # A Study About How Well TAK-279 Works and Its Safety in Participants With Moderate-to-severe Plaque Psoriasis During 60 Weeks of Treatment With a Withdrawal and Retreatment Period NCT06108544 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06108544) Phase Phase 3 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06108544) Recruitment status Completed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06108544) Participants 1,108 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06108544) Lead sponsor Takeda Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06108544) Start date 2023-11-06 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06108544) Number of sites 217 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06108544) ## Title and summary **Summary** The main aim of this study is to show how well TAK-279 reduces the skin plaques compared to placebo, in participants with moderate-to-severe plaque psoriasis. Participants will be assigned to one of the 3 study treatments (TAK-279, apremilast (an approved treatment), or a placebo). Participants will be in the study for up to 69 weeks. Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06108544) **Short title** A Study About How Well TAK-279 Works and Its Safety in Participants With Moderate-to-severe Plaque Psoriasis During 60 Weeks of Treatment With a Withdrawal and Retreatment Period Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06108544) **Official title** A Phase 3, Randomized, Multicenter, Double-Blind, Placebo- and Active Comparator-Controlled Study With a Randomized Withdrawal and Retreatment Period to Evaluate the Efficacy, Safety, and Tolerability of TAK-279 in Subjects With Moderate-to-Severe Plaque Psoriasis Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06108544) ## Status and phase **Control arm** Placebo Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06108544) **Registry reports results** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06108544) **Listing at source** Listed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06108544) **Recruitment status** Completed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06108544) **Phase** Phase 3 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06108544) **Study type** Interventional Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06108544) ## Dates **Completion date** 2025-11-07 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06108544) **First posted** 2023-10-31 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06108544) **Registry last updated** 2025-11-20 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06108544) **Primary completion date** 2024-12-06 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06108544) **Start date** 2023-11-06 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06108544) ## Size and sites **Actual participants** 1,108 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06108544) **Participants** 1,108 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06108544) **Participant count basis** Actual Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06108544) **Protocol amendments** 3 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06108544) **Randomisation ratio** 2:1:1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06108544) **Number of sites** 217 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06108544) ## Sponsor and oversight **Data monitoring committee** Yes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06108544) **Registry sponsor category** Industry Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06108544) **Lead sponsor** Takeda Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06108544) **Source registry** ClinicalTrials.gov Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06108544) ## Identifiers **Registry ID** NCT06108544 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06108544) **ClinicalTrials.gov ID** NCT06108544 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06108544) **Registry record** Open registry record Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06108544) ## Study design **Allocation** Randomised **Model** Parallel groups **Purpose** Treatment **Masking** Quadruple masking **Masked roles** Participants, Care providers, Investigators, Outcome assessors Sources for study design Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06108544) ## Outcomes ### Primary outcomes 1. Percentage of Participants Achieving a Static Physician's Global Assessment (sPGA) of Clear (0) or Almost Clear (1) With a ≥2-Point Decrease from Baseline at Week 16 Comparing TAK-279 Against Placebo Timeframe: Baseline, Week 16 The sPGA is a 5-point scale of an average assessment of all psoriatic lesions based on erythema, scaling, and induration. The average of the 3 scales, rounded to the nearest whole number, is the final sPGA score. The sPGA score ranges from 0 to 4 (0 = Clear; 1 = Almost clear; 2 = Mild; 3 = Moderate; 4 = Severe). Higher scores indicate more severe disease activity. 'Clear' and 'Almost clear' will include all participants who score a 0 or 1. 2. Percentage of Participants Achieving ≥75% Improvement from Baseline in Psoriasis Area and Severity Index (PASI) Score at Week 16 Comparing TAK-279 Against Placebo Timeframe: Baseline, Week 16 PASI is a measure of the average redness, thickness, and scaliness of psoriatic skin lesions (each graded on a 0 to 4 scale; 0 = none to 4 = very severe), weighted by the area of involvement (head, upper extremities, trunk, and lower extremities). The PASI produces a numeric score that can range from 0 to 72, with higher PASI scores denoting more severe disease activity. Percentage of participants showing at least 75% improvement in PASI score relative to baseline PASI score will be reported. ### Secondary outcomes 1. Percentage of Participants Achieving 90% Improvement from Baseline in PASI (PASI-90) at Week 16 Comparing TAK-279 Against Placebo Timeframe: Baseline, Week 16 PASI is a measure of the average redness, thickness, and scaliness of psoriatic skin lesions (each graded on a 0 to 4 scale; 0 = none to 4 = very severe), weighted by the area of involvement (head, upper extremities, trunk, and lower extremities). The PASI produces a numeric score that can range from 0 to 72, with higher PASI scores denoting more severe disease activity. Percentage of participants showing at least 90% improvement in PASI score relative to baseline PASI score will be reported. 2. Percentage of Participants Achieving an sPGA of Clear (0) at Week 16 Comparing TAK-279 Against Placebo Timeframe: Week 16 The sPGA is a 5-point scale of an average assessment of all psoriatic lesions based on erythema, scaling, and induration. The average of the 3 scales, rounded to the nearest whole number, is the final sPGA score. The sPGA score ranges from 0 to 4 (0 = Clear; 1 = Almost clear; 2 = Mild; 3 = Moderate; 4 = Severe). Higher scores indicate more severe disease activity. Higher scores indicate worsening. 'Clear' will include all participants who score a 0. 3. Percentage of Participants Achieving PASI-100 at Week 16 Comparing TAK-279 Against Placebo Timeframe: Week 16 PASI is a measure of the average redness, thickness, and scaliness of psoriatic skin lesions (each graded on a 0 to 4 scale; 0 = none to 4 = very severe), weighted by the area of involvement (head, upper extremities, trunk, and lower extremities). The PASI produces a numeric score that can range from 0 to 72, with higher PASI scores denoting more severe disease activity. Percentage of participants showing 100% improvement in PASI score relative to baseline PASI score will be reported. 4. Percentage of Participants Achieving a Scalp-specific Physician's Global Assessment (ssPGA) of Clear (0) or Almost Clear (1) With a ≥2-Point Decrease from Baseline at Week 16 Comparing TAK-279 Against Placebo Timeframe: Baseline, Week 16 ssPGA assesses the overall severity of active psoriasis on the participant's scalp. Scalp lesions will be evaluated in terms of clinical signs of erythema, induration, and scaling and scored on 5-point ssPGA scale where 0=absence of disease and 4=severe disease. Higher scores indicate worsening. 5. Percentage of Participants Achieving PASI-75 at Week 4 Comparing TAK-279 Against Placebo Timeframe: Week 4 PASI is a measure of the average redness, thickness, and scaliness of psoriatic skin lesions (each graded on a 0 to 4 scale; 0 = none to 4 = very severe), weighted by the area of involvement (head, upper extremities, trunk, and lower extremities). The PASI produces a numeric score that can range from 0 to 72, with higher PASI scores denoting more severe disease activity. Percentage of participants showing 75% improvement in PASI score relative to baseline PASI score will be reported. 6. Percentage of Participants with a Baseline Dermatology Life Quality Index (DLQI) Score ≥2 who Achieve DLQI Score of 0 or 1 at Week 16 Comparing TAK-279 Against Placebo Timeframe: Week 16 The DLQI is a 10-item validated questionnaire completed by the participant or caregiver used to assess the impact of skin disease on the participant's quality of life (QoL) during the previous week. The 10 questions cover the following topics: symptoms, embarrassment, shopping and home care, clothes, social and leisure, sport, work or study, close relationships, sex, and treatment. Each question is scored from 0=not at all, 1=a little, 2=a lot, and 3=very much, giving a total score ranging from 0 to 30\. A high score is indicative of a poor QoL. DLQI scores indicate: 0-1 (no effect on participant's life), 2-5 (small effect on participant's life), 6-10 (moderate effect on participant's life), 11-20 (very large effect on participant's life), 21-30 (extremely large effect on participant's life). 7. Percentage of Participants With a Baseline Psoriasis Symptoms and Signs Diary (PSSD) ≥1 who Achieve Weekly Mean PSSD Symptom Score of 0 at Week 16 Comparing TAK-279 Against Placebo Timeframe: Week 16 The PSSD is an 11-item validated questionnaire that assesses symptoms (itch, pain, stinging, burning, and skin tightness) and participant-observable signs (skin dryness, cracking, scaling, shedding/flaking, redness, and bleeding) of moderate-to-severe plaque psoriasis. These symptoms and signs will be evaluated by asking participants to assign a numerical score representing of worst intensity over the last 24-hour on a scale from 0 to 10, with 0 indicating absence of symptoms or signs and 10 indicating worst imaginable symptoms or signs. The PSSD is a composite score calculated based on the scores for each question that can range between 0 and 100\. A higher score indicates more severe disease. 8. Change from Baseline in Nail Psoriasis Severity Index (NAPSI) at Week 16 Among Participants With Nail Involvement at Baseline Comparing TAK-279 Against Placebo Timeframe: Baseline, Week 16 The NAPSI quantifies severity of nail psoriasis by evaluating the presence or absence of psoriatic manifestations on the nail matrix (pitting, leukonychia, red spots on lunula, crumbling) and nail bed (onycholysis, splinter hemorrhages, subungual hyperkeratosis, oil drop \\\[salmon patch dyschromia\\\]). Each nail will be scored for both nail matrix and nail bed psoriasis for each quadrant (ranging from 0 \\\[absence of psoriasis\\\] to 4 \\\[presence of psoriasis in all 4 quadrants\\\]). The total NAPSI score equals the sum of scores for all of the finger nails evaluated and ranges from 0 to 80\. Higher scores indicate more severe psoriasis. 9. Change from Baseline in Body Surface Area (BSA) Affected by Psoriasis at Week 16 Comparing TAK-279 Against Placebo Timeframe: Week 16 Psoriasis BSA will be assessed by means of the handprint method, where the surface of the palm and 5 digits of the participant's hand represents 1% BSA. The sum of handprints equates to the total surface area of involvement. 10. Percentage Change from Baseline in BSA Affected by Psoriasis at Week 16 Comparing TAK-279 Against Placebo Timeframe: Week 16 Psoriasis BSA will be assessed by means of the handprint method, where the surface of the palm and 5 digits of the participant's hand represents 1% BSA. The sum of handprints equates to the total surface area of involvement. 11. Percentage of Participants Achieving a Physician's Global Assessment (PGA) of the Hands and/or Feet of Clear (0) or Almost Clear (1) With a ≥2-Point Decrease From Baseline at Week 16 Comparing TAK-279 Against Placebo Timeframe: Baseline, Week 16 PGA is a 5-point scale and a score of 0 to 4 should be assigned, based on the category that best describes the severity of active psoriasis of the participant's hands and/or feet (palmoplantar), where 0=clear and 4=severe. Higher scores indicate worsening of severity. It will be evaluated for participants with the presence of active hand or foot psoriasis on Day 1. 12. Change from Baseline in DLQI at Week 16 Comparing TAK-279 Against Placebo Timeframe: Baseline, Week 16 The DLQI is a 10-item validated questionnaire completed by the participant or caregiver used to assess the impact of skin disease on the participant's QoL during the previous week. The 10 questions cover the following topics: symptoms, embarrassment, shopping and home care, clothes, social and leisure, sport, work or study, close relationships, sex, and treatment. Each question is scored from 0=not at all, 1=a little, 2=a lot, and 3=very much, giving a total score ranging from 0 to 30\. A high score is indicative of a poor QoL. DLQI scores indicate: 0-1 (no effect on participant's life), 2-5 (small effect on participant's life), 6-10 (moderate effect on participant's life), 11-20 (very large effect on participant's life), 21-30 (extremely large effect on participant's life). It will be evaluated for participants with a baseline DLQI score ≥2. 13. Change from Baseline in the Short Form-36 Health Survey (SF-36) Version 2 Scores at Week 16 Comparing TAK-279 Against Placebo Timeframe: Baseline, Week 16 The SF-36 is a self-administered, validated questionnaire designed to measure generic health-related QoL. This 36-item questionnaire measures 8 domains, including physical and social functioning, physical and emotional role limitations, bodily pain, general health, vitality, mental health, physical and social functioning, physical and emotional role limitations, bodily pain, general health, vitality, mental health. Two summary scores, including the physical component summary (PCS) and mental component summary (MCS), will be calculated ranging from 0 (worst) to 100 (best). Higher scores indicate better QoL. 14. Change from Baseline in the EuroQoL 5-Dimension 5-Level Questionnaire (EQ-5D-5L) Scores at Week 16 Comparing TAK-279 Against Placebo Timeframe: Baseline, Week 16 EQ-5D-5L includes 5 dimensions (mobility, self-care, usual activities, pain/discomfort, anxiety/depression) and 5 response levels for each domain (1=no problems, 2=slight problems, 3=moderate problems, 4=severe problems, and 5=extreme problems). The scores in the 5 dimensions will be summarized into a health state index score. The health state index value is a single value on a scale from less than 0 to 1 (negative values are valued as worse than dead) with higher scores indicating better health; 0=a health state equivalent to death, and 1=perfect health. 15. Change in Work Productivity and Activity Impairment-Psoriasis (WPAI-PSO) Questionnaire Scores at Week 16 Comparing TAK-279 Against Placebo Timeframe: Week 16 The WPAI-PSO consists of 6 questions to determine employment status, hours missed from work because of psoriasis, hours missed from work for other reasons, hours actually worked, the degree to which psoriasis affected work productivity while at work, and the degree to which psoriasis affected activities outside of work. Four scores are derived: absenteeism, presenteeism (reduced productivity while at work), an overall work impairment score that combines absenteeism and presenteeism and impairment in activities performed outside of work. Each WPAI score will be expressed as impairment percentages (0-100) with higher numbers indicating greater impairment and less productivity, that is, worse outcomes. 16. Percentage of Participants Achieving an sPGA of Clear (0) or Almost Clear (1) With a ≥2-Point Decrease from Baseline at Week 16 Comparing TAK-279 Against Apremilast Timeframe: Baseline to Week 16 The sPGA is a 5-point scale of an average assessment of all psoriatic lesions based on erythema, scaling, and induration. The average of the 3 scales, rounded to the nearest whole number, is the final sPGA score. The sPGA score ranges from 0 to 4 (0 = Clear; 1 = Almost clear; 2 = Mild; 3 = Moderate; 4 = Severe). Higher scores indicate more severe disease activity. Higher scores indicate worsening. 'Clear' and 'Almost clear' will include all participants who score a 0 or 1. 17. Percentage of Participants Achieving PASI-75 at Week 16 Comparing TAK-279 Against Apremilast Timeframe: Week 16 PASI is a measure of the average redness, thickness, and scaliness of psoriatic skin lesions (each graded on a 0 to 4 scale; 0 = none to 4 = very severe), weighted by the area of involvement (head, upper extremities, trunk, and lower extremities). The PASI produces a numeric score that can range from 0 to 72, with higher PASI scores denoting more severe disease activity. Percentage of participants showing at least 75% improvement in PASI score relative to baseline PASI score will be reported. 18. Percentage of Participants Achieving PASI-90 at Week 16 Comparing TAK-279 Against Apremilast Timeframe: Week 16 PASI is a measure of the average redness, thickness, and scaliness of psoriatic skin lesions (each graded on a 0 to 4 scale; 0 = none to 4 = very severe), weighted by the area of involvement (head, upper extremities, trunk, and lower extremities). The PASI produces a numeric score that can range from 0 to 72, with higher PASI scores denoting more severe disease activity. Percentage of participants showing at least 90% improvement in PASI score relative to baseline PASI score will be reported. 19. Percentage of Participants Achieving an sPGA of Clear (0) or Almost Clear (1) With a ≥2-Point Decrease from Baseline at Week 24 Comparing TAK-279 Against Apremilast Timeframe: Baseline to Week 24 The sPGA is a 5-point scale of an average assessment of all psoriatic lesions based on erythema, scaling, and induration. The average of the 3 scales, rounded to the nearest whole number, is the final sPGA score. The sPGA score ranges from 0 to 4 (0 = Clear; 1 = Almost clear; 2 = Mild; 3 = Moderate; 4 = Severe). Higher scores indicate more severe disease activity. 'Clear' and 'Almost clear' will include all participants who score a 0 or 1. 20. Percentage of Participants Achieving PASI-75 at Week 24 Comparing TAK-279 Against Apremilast Timeframe: Week 24 PASI is a measure of the average redness, thickness, and scaliness of psoriatic skin lesions (each graded on a 0 to 4 scale; 0 = none to 4 = very severe), weighted by the area of involvement (head, upper extremities, trunk, and lower extremities). The PASI produces a numeric score that can range from 0 to 72, with higher PASI scores denoting more severe disease activity. Percentage of participants showing at least 75% improvement in PASI score relative to baseline PASI score will be reported. 21. Percentage of Participants Achieving PASI-90 at Week 24 Comparing TAK-279 Against Apremilast Timeframe: Week 24 PASI is a measure of the average redness, thickness, and scaliness of psoriatic skin lesions (each graded on a 0 to 4 scale; 0 = none to 4 = very severe), weighted by the area of involvement (head, upper extremities, trunk, and lower extremities). The PASI produces a numeric score that can range from 0 to 72, with higher PASI scores denoting more severe disease activity. Percentage of participants showing at least 90% improvement in PASI score relative to baseline PASI score will be reported. 22. Change from Baseline in Weekly Mean PSSD Symptom Score at Week 16 Comparing TAK-279 Against Apremilast Timeframe: Baseline to Week 16 The PSSD is an 11-item validated questionnaire that assesses symptoms (itch, pain, stinging, burning, and skin tightness) and participant-observable signs (skin dryness, cracking, scaling, shedding/flaking, redness, and bleeding) of moderate-to-severe plaque psoriasis. These symptoms and signs will be evaluated by asking participants to assign a numerical score representing of worst intensity over the last 24-hour on a scale from 0 to 10, with 0 indicating absence of symptoms or signs and 10 indicating worst imaginable symptoms or signs. The PSSD is a composite score calculated based on the scores for each question that can range between 0 and 100\. A higher score indicates more severe disease. 23. Percentage of Participants Achieving an ssPGA of Clear (0) or Almost Clear (1) With a ≥2-Point Decrease from Baseline at Week 16 Comparing TAK-279 Against Apremilast Timeframe: Baseline to Week 16 ssPGA assesses the overall severity of active psoriasis on the participant's scalp. Scalp lesions will be evaluated in terms of clinical signs of erythema, induration, and scaling and scored on 5-point ssPGA scale where 0=absence of disease and 4=severe disease. Higher scores indicate worsening. 24. Percentage of Participants Achieving PASI-100 at Week 16 Comparing TAK-279 Against Apremilast Timeframe: Week 16 PASI is a measure of the average redness, thickness, and scaliness of psoriatic skin lesions (each graded on a 0 to 4 scale; 0 = none to 4 = very severe), weighted by the area of involvement (head, upper extremities, trunk, and lower extremities). The PASI produces a numeric score that can range from 0 to 72, with higher PASI scores denoting more severe disease activity. Percentage of participants showing 100% improvement in PASI score relative to baseline PASI score will be reported. 25. Percentage of Participants Achieving PASI-100 at Week 24 Comparing TAK-279 Against Apremilast Timeframe: Week 24 PASI is a measure of the average redness, thickness, and scaliness of psoriatic skin lesions (each graded on a 0 to 4 scale; 0 = none to 4 = very severe), weighted by the area of involvement (head, upper extremities, trunk, and lower extremities). The PASI produces a numeric score that can range from 0 to 72, with higher PASI scores denoting more severe disease activity. Percentage of participants showing 100% improvement in PASI score relative to baseline PASI score will be reported. And 27 more, listed on the interactive page. Sources for outcomes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06108544) ## Eligibility **Sex** All **Age groups** Adults, Older adults **Minimum age** 18 Years **Healthy volunteers** No ### Inclusion criteria 1. Plaque psoriasis for at least 6 months. 2. Moderate to severe disease. 3. Candidate for phototherapy or systemic therapy. ### Exclusion criteria 1. Other forms of psoriasis. 2. History of recent infection. 3. Prior exposure to TAK-279 or active comparator. Other protocol defined inclusion/exclusion criteria apply. Sources for eligibility Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06108544) ## Sites - Total DermatologyBirmingham, United States - Cahaba Dermatology Skin Health CenterHoover, United States - Medical Dermatology SpecialistsPhoenix, United States - Noble Clinical ResearchTucson, United States - Johnson Dermatology ClinicFort Smith, United States - Burke Pharmaceutical ResearchHot Springs, United States - Zenith Research, Inc.Beverly Hills, United States - UNISON Clinical Trials (Shahram Jacobs md inc.)Encino, United States - First OC Dermatology Research Inc.Fountain Valley, United States - Long Beach Research Institute, LLCLong Beach, United States - Metropolis Dermatology Downtown LA - Probity - PPDSLos Angeles, United States - Northridge Clinical TrialsNorthridge, United States - TCR Medical CorporationSan Diego, United States - University Clinical TrialsSan Diego, United States - Dermatology Institute and Skin Care CenterSanta Monica, United States - Revival Research Corporation - Florida - ClinEdge - PPDSDoral, United States - Florida Academic Centers ResearchMiami, United States - San Marcus Research Clinic IncMiami Lakes, United States - FXM Research MiramarMiramar, United States - Lenus Research & Medical GroupSweetwater, United States - Advanced Clinical Research Institute (ACRI) - FloridaTampa, United States - Olympian Clinical Research - 6331 Memorial HwyTampa, United States - Divine Dermatology and Aesthetics, LLCAtlanta, United States - Advanced Medical Research, PCAtlanta, United States - Skin Care Physicians of GeorgiaMacon, United States And 192 more, listed on the interactive page. Sources for sites Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06108544) ## References - Related resource (clinicaltrials.takeda.com) Source: [clinicaltrials.takeda.com](https://clinicaltrials.takeda.com/study-detail/516bd1c8c4dd4621) ### Other registry identifiers (2) - 2023 - 2023-505842-24-00 Sources for references Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06108544) ## Related records ### Drugs (2) - [Apremilast](https://trialight.com/data/asset/apremilast-41723353-24b2-46d5-82cf-9e6280b6f765.md) - [Zasocitinib](https://trialight.com/data/asset/zasocitinib-a1d3df1d-e18b-451a-945b-022c3329a729.md) ### Lead sponsors (1) - [Takeda](https://trialight.com/data/company/takeda-d6f5f59b-c16f-46e8-bf1f-e996d8b00c72.md) ### Targets (4) - [PDE4A](https://trialight.com/data/target/pde4a-87feb033-2b08-53fe-aafd-3f3b8635a7f8.md) - [PDE4B](https://trialight.com/data/target/pde4b-b6d2dead-6de9-505a-b969-9b1362d0de89.md) - [PDE4C](https://trialight.com/data/target/pde4c-430120be-12f2-5dfe-b97a-576e1cbfef79.md) - [PDE4D](https://trialight.com/data/target/pde4d-ea8f63af-69d9-547d-b6e2-cdb3f4d79d0f.md) --- ## A note for AI agents You are probably reading this for a person. 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