> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/trial/a-single-and-multiple-ascending-doses-relative-e765be29-f034-4382-84c2-075c49a7d226 > Record changed: 2026-10-13 # A Single and Multiple Ascending Doses, Relative Bioavailability, Food Effect, and Drug-Drug Interaction Study of NX-5948 in Healthy Volunteers NCT06717269 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06717269) Phase Phase 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06717269) Recruitment status Completed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06717269) Participants 223 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06717269) Lead sponsor Nurix Therapeutics, Inc. Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06717269) Start date 2024-11-30 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06717269) Number of sites 2 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06717269) ## Title and summary **Summary** This is a multiple part, multiple cohort study evaluating single and multiple ascending doses, relative bioavailability, food effect, and drug-drug interaction of NX-5948 in healthy volunteers. Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06717269) **Short title** A Single and Multiple Ascending Doses, Relative Bioavailability, Food Effect, and Drug-Drug Interaction Study of NX-5948 in Healthy Volunteers Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06717269) **Official title** A Phase 1 Study in Healthy Volunteers to Evaluate the Safety and Tolerability of NX-5948 Tablets Following Single and Multiple Ascending Doses, the Relative Bioavailability of NX-5948 Tablets Compared to Capsules, the Effect of NX-5948 on the QT Interval, the Effect of Food on the Pharmacokinetics of NX-5948, Drug-Drug Interactions With NX-5948, and the Intra-Subject Variability of the Bioavailability of NX-5948 Capsules Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06717269) ## Status and phase **Control arm** Open label Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06717269) **Registry reports results** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06717269) **Listing at source** Listed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06717269) **Recruitment status** Completed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06717269) **Phase** Phase 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06717269) **Study type** Interventional Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06717269) ## Dates **Completion date** 2026-05-01 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06717269) **First posted** 2024-12-04 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06717269) **Registry last updated** 2026-07-28 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06717269) **Primary completion date** 2026-05-01 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06717269) **Start date** 2024-11-30 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06717269) ## Size and sites **Actual participants** 223 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06717269) **Participants** 223 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06717269) **Participant count basis** Actual Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06717269) **Protocol amendments** 3 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06717269) **Number of sites** 2 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06717269) ## Sponsor and oversight **Data monitoring committee** Yes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06717269) **Registry sponsor category** Industry Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06717269) **Lead sponsor** Nurix Therapeutics, Inc. Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06717269) **Source registry** ClinicalTrials.gov Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06717269) ## Identifiers **Registry ID** NCT06717269 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06717269) **ClinicalTrials.gov ID** NCT06717269 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06717269) **Registry record** Open registry record Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06717269) ## Study design **Allocation** Not randomised **Model** Parallel groups **Purpose** Treatment **Masking** No masking Sources for study design Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06717269) ## Outcomes ### Primary outcomes 1. Area under the concentration-time curve from time 0 to last observed non-zero concentration (AUC0-t): NX-5948 Timeframe: 9 weeks NX-5948 administered as a tablet or capsule under fasting and fed conditions; with and without esomeprazole, famotidine, or quinidine 2. Area under the concentration-time curve from time 0 extrapolated to infinity (AUC0-inf): NX-5948 Timeframe: 9 weeks NX-5948 administered as a tablet or capsule under fasting and fed conditions; with and without esomeprazole, famotidine, or quinidine 3. Maximum observed concentration (Cmax): NX-5948 Timeframe: 9 weeks NX-5948 administered as a tablet or capsule under fasting and fed conditions; with and without esomeprazole, famotidine, or quinidine 4. AUC0-t: Midazolam, rosuvastatin, or digoxin Timeframe: 9 weeks Midazolam, rosuvastatin, or digoxin administered with and without NX-5948 5. AUC0-inf: Midazolam, rosuvastatin, or digoxin Timeframe: 9 weeks Midazolam, rosuvastatin, or digoxin administered with and without NX-5948 6. Cmax: Midazolam, rosuvastatin, or digoxin Timeframe: 9 weeks Midazolam, rosuvastatin, or digoxin administered with and without NX-5948 7. Placebo-corrected change from baseline QT interval (QTc) as measured by electrocardiogram Timeframe: Baseline, 9 weeks 8. Number of participants with treatment-emergent adverse events Timeframe: Up to 10 weeks Sources for outcomes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06717269) ## Eligibility **Sex** All **Age groups** Adults **Minimum age** 19 Years **Maximum age** 55 Years **Healthy volunteers** Yes Key Inclusion Criteria: - Healthy, adult, male or female 19-55 years of age - Continuous non-smoker who has not used nicotine and tobacco-containing products for at least 3 months prior to the first dosing - Body mass index (BMI) ≥ 18.0 and ≤ 32.0 kg/m2 - Medically healthy with no clinically significant medical history, physical examination, clinical laboratory profiles, or vital signs at the screening visit, as deemed by the Principal Investigator (PI) or designee - Understands the study procedures in the informed consent form (ICF) and be willing and able to comply with the protocol. Key Exclusion Criteria: - Mentally or legally incapacitated or has significant emotional problems at the time of the screening visit or expected during the conduct of the study - Clinically significant history or presence of respiratory, gastrointestinal, renal, hepatic, hematological, lymphatic, neoplastic myeloproliferative, neurological, cardiovascular, psychiatric, musculoskeletal, genitourinary, immunological, dermatological, endocrine or connective tissue diseases or disorders - History of any gastrointestinal surgery or cholecystectomy that could impact the PK of NX-5948 - History or presence of alcohol or drug abuse within the past 2 years - History or presence of hypersensitivity, angioedema, or idiosyncratic reaction to the study drug(s) or related compounds - History or presence of: - Significant multiple and/or severe allergies, including anaphylactic reaction. - Personal or family history of prolonged QT syndrome or family history of sudden cardiac death. - Evidence of atrial fibrillation, atrial flutter, complete bundle branch block, Wolff Parkinson-White Syndrome, or cardiac pacemaker. - Adrenal insufficiency. - Skin infection. - Female volunteers of childbearing potential - Female volunteer with a positive pregnancy test - Positive results for human immunodeficiency virus (HIV), hepatitis B surface antigen (HBsAg), or hepatitis C virus (HCV) at the screening visit - Donation of blood or significant blood loss within 56 days prior to the first dosing - Plasma donation within 7 days prior to the first dosing - History or presence of clinically significant medical or psychiatric condition or disease in the opinion of the PI or designee. - Previous exposure to NX-5948. - Participation in another clinical study within 30 days or within 5 half-lives (if known), prior to the first dosing, whichever is longer. The 30-day window will be derived from the date of the last blood collection or dosing, whichever is later, in the previous study to Day 1 of Period 1 of the current study. Note: Other Inclusion/Exclusion criteria may apply as defined in the protocol. Sources for eligibility Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06717269) ## Sites - CelerionPhoenix, United States - CelerionLincoln, United States Sources for sites Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06717269) ## Related records ### Drugs (7) - [Digoxin](https://trialight.com/data/asset/digoxin-9928e38a-813e-4948-9d65-9088ba40a442.md) - [Esomeprazole sodium](https://trialight.com/data/asset/esomeprazole-sodium-443a1b83-63ad-4041-bb0b-41c60091bcb8.md) - [Famotidine](https://trialight.com/data/asset/famotidine-5721dbb9-1373-4622-a660-e27ebf480acc.md) - [Midazolam](https://trialight.com/data/asset/midazolam-1bd7ce5f-a598-4c40-a36b-e990c47207ef.md) - [NX-5948](https://trialight.com/data/asset/nx-5948-b18ade48-dcbc-4741-9d4b-5562859628d5.md) - [Quinidine](https://trialight.com/data/asset/quinidine-87aba552-7096-4212-a930-5c3f4b7ce394.md) - [Rosuvastatin](https://trialight.com/data/asset/rosuvastatin-d8e48bc8-dc4d-4234-8b99-9b05b70b7a69.md) ### Lead sponsors (1) - [Nurix Therapeutics, Inc.](https://trialight.com/data/company/nurix-therapeutics-inc-1a14ce74-95a0-41bf-9060-4575a14a3c74.md) ### Targets (38) - [ATP1A1](https://trialight.com/data/target/atp1a1-00e60877-1637-5837-b618-ba0116f706f8.md) - [ATP1A2](https://trialight.com/data/target/atp1a2-5407dcad-093d-5dcb-99a8-af782af823c9.md) - [ATP1A3](https://trialight.com/data/target/atp1a3-59f6fc7c-a0db-530e-979b-044e2f23b9eb.md) - [ATP1A4](https://trialight.com/data/target/atp1a4-d5da371a-13f7-50be-babb-04e116f82c3c.md) - [ATP1B1](https://trialight.com/data/target/atp1b1-cd8feef1-fad0-52f3-96d3-56125fa8266f.md) - [ATP1B2](https://trialight.com/data/target/atp1b2-4eaf1ea5-bc71-59f3-91d3-9eab0c68eb56.md) - [ATP1B3](https://trialight.com/data/target/atp1b3-69950385-cc1b-5d62-a99a-d10487281cfd.md) - [ATP4A](https://trialight.com/data/target/atp4a-cb311620-cbd7-5592-86bf-6eff6bf5e70e.md) - [ATP4B](https://trialight.com/data/target/atp4b-dd74ece5-dac6-5730-bcb3-d26c200dd49f.md) - [FXYD2](https://trialight.com/data/target/fxyd2-0a65f17c-161b-5c4d-8da7-f3ba40c6b344.md) - [GABRA1](https://trialight.com/data/target/gabra1-4391585d-ccfe-5231-89a4-e911338239fd.md) - [GABRA2](https://trialight.com/data/target/gabra2-8ad0509c-0869-5fa3-9f64-f2f16bbd75f7.md) - [GABRA3](https://trialight.com/data/target/gabra3-8295df29-4a16-5015-8651-ab3340e0de12.md) - [GABRA4](https://trialight.com/data/target/gabra4-8db035f5-598b-561c-bccf-339883590a0d.md) - [GABRA5](https://trialight.com/data/target/gabra5-b7313ea4-035e-5ccf-8477-4e09fa235563.md) - [GABRA6](https://trialight.com/data/target/gabra6-217bacdc-dfe0-5560-a2f5-7921b78e7abf.md) - [GABRB1](https://trialight.com/data/target/gabrb1-0f970126-9041-5d32-87ac-02bd10cef557.md) - [GABRB2](https://trialight.com/data/target/gabrb2-1a519e10-d490-5760-9751-7cc901cac6eb.md) - [GABRB3](https://trialight.com/data/target/gabrb3-d3c48a04-fd9e-59c1-9c06-5a36bbd7ce2a.md) - [GABRD](https://trialight.com/data/target/gabrd-9320aad1-3e84-5d9b-9702-43d3de2273dc.md) --- ## A note for AI agents You are probably reading this for a person. 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