> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/trial/a-relative-bioavailability-study-of-ly3209590-in-healthy-5fb3a1ad-dc2c-43d2-9944-c2cd9b96284c > Record changed: 2026-10-13 # A Relative Bioavailability Study of LY3209590 in Healthy Participants NCT05615532 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05615532) Phase Phase 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05615532) Recruitment status Completed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05615532) Participants 168 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05615532) Lead sponsor Eli Lilly and Company Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05615532) Start date 2022-11-11 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05615532) Number of sites 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05615532) ## Title and summary **Summary** The study will be conducted in two parts (part A and part B). The main purpose of this study is to compare the amount of LY3209590 that gets into the blood stream and how long it takes the body to get rid of it, when self-administered at different body sites, abdominal wall, upper arm and thigh (part A), when administered by two different routes of injection, subcutaneously or intravenously (part B) in healthy participants. The study may last up to 65 (part A) and 184 (part B) days, respectively. Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05615532) **Short title** A Relative Bioavailability Study of LY3209590 in Healthy Participants Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05615532) **Official title** Effect of Injection Site on the Relative Bioavailability of Single Dose of LY3209590 and Evaluation of Absolute Bioavailability of LY3209590 in Healthy Participants Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05615532) ## Status and phase **Control arm** Open label Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05615532) **Registry reports results** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05615532) **Listing at source** Listed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05615532) **Recruitment status** Completed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05615532) **Phase** Phase 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05615532) **Study type** Interventional Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05615532) ## Dates **Completion date** 2023-06-28 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05615532) **First posted** 2022-11-14 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05615532) **Registry last updated** 2024-06-12 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05615532) **Primary completion date** 2023-06-28 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05615532) **Start date** 2022-11-11 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05615532) ## Size and sites **Actual participants** 168 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05615532) **Participants** 168 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05615532) **Participant count basis** Actual Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05615532) **Protocol amendments** 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05615532) **Number of sites** 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05615532) ## Sponsor and oversight **Data monitoring committee** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05615532) **Registry sponsor category** Industry Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05615532) **Lead sponsor** Eli Lilly and Company Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05615532) **Source registry** ClinicalTrials.gov Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05615532) ## Identifiers **Registry ID** NCT05615532 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05615532) **ClinicalTrials.gov ID** NCT05615532 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05615532) **Registry record** Open registry record Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05615532) ## Study design **Allocation** Randomised **Model** Parallel groups **Purpose** Basic science **Masking** No masking Sources for study design Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05615532) ## Outcomes ### Primary outcomes 1. Part A: Pharmacokinetics (PK): Area Under the Plasma Concentration Versus Time Curve From Zero to Infinity (AUC\[0-∞\]) of LY3209590 Timeframe: Predose on Day 1 through Day 65 Part A: PK: AUC0-∞ of LY3209590 ### Secondary outcomes 1. Part B: PK: AUC0-∞ of LY3209590 Timeframe: Predose on Day 1 through Day 65 Part B: PK: AUC0-∞ of LY3209590 Sources for outcomes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05615532) ## Eligibility **Sex** All **Age groups** Adults, Older adults **Minimum age** 21 Years **Maximum age** 65 Years **Healthy volunteers** Yes ### Inclusion criteria - Male or female participants who are overtly healthy as determined by medical evaluation - Participants with body mass index (BMI) within the range 18.5 to 35.0 kilograms per meter squared (kg/m²) - Male or female participants must agree to use contraception ### Exclusion criteria - Have a history of multiple or severe allergic reactions or a history of severe anaphylactic reaction - Have known allergies to LY3209590, related compounds, or any components of the formulation - Have an abnormality in the 12-lead electrocardiogram - Intend to use prescription medication, including herbal medications and traditional medications - Show evidence of human immunodeficiency virus infection or positive human immunodeficiency virus antibodies, hepatitis C or positive hepatitis C antibody, or hepatitis B or positive hepatitis B surface antigen - Are lactating or pregnant Sources for eligibility Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05615532) ## Sites - Lilly Centre for Clinical PharmacologySingapore, Singapore Sources for sites Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05615532) ## References ### Other registry identifiers - I8H-MC-BDDD Sources for references Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05615532) ## Related records ### Drugs (1) - [Insulin efsitora alfa](https://trialight.com/data/asset/insulin-efsitora-alfa-9de5c01f-5ba8-4897-93f1-75044083ba25.md) ### Lead sponsors (1) - [Eli Lilly and Company](https://trialight.com/data/company/eli-lilly-and-company-9da7efcc-bafe-4b95-b30b-e87a97770db7.md) --- ## A note for AI agents You are probably reading this for a person. 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