> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/trial/a-phase-iii-of-covid-19-vaccine-eucorvac-19-in-healthy-30399a3a-ef75-4057-af37-a9ac7752bcf9 > Record changed: 2026-11-04 # A Phase III of COVID-19 Vaccine EuCorVac-19 in Healthy Adults Aged 18 Years and Older NCT05603052 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05603052) Phase Phase 3 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05603052) Recruitment status Completed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05603052) Participants 2,852 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05603052) Lead sponsor EuBiologics Co.,Ltd Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05603052) Start date 2022-07-11 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05603052) Number of sites 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05603052) ## Title and summary **Summary** A phase III, randomized, observer-blind, active-controlled, parallel-group, multi-center study to evaluate immunogenicity and safety of a preventive COVID-19 vaccine EuCorVac-19 in healthy adults aged 18 years and older Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05603052) **Short title** A Phase III of COVID-19 Vaccine EuCorVac-19 in Healthy Adults Aged 18 Years and Older Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05603052) **Official title** A Phase III, Randomized, Observer-blind, Active-controlled, Parallel-group, Multi-center Study to Evaluate Immunogenicity and Safety of a Preventive COVID-19 Vaccine EuCorVac-19 in Healthy Adults Aged 18 Years and Older Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05603052) ## Status and phase **Control arm** Active comparator Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05603052) **Registry reports results** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05603052) **Listing at source** Listed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05603052) **Recruitment status** Completed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05603052) **Phase** Phase 3 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05603052) **Study type** Interventional Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05603052) ## Dates **Completion date** 2024-01-15 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05603052) **First posted** 2022-11-02 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05603052) **Registry last updated** 2025-01-07 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05603052) **Primary completion date** 2024-01-15 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05603052) **Start date** 2022-07-11 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05603052) ## Size and sites **Actual participants** 2,852 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05603052) **Participants** 2,852 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05603052) **Participant count basis** Actual Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05603052) **Protocol amendments** 3 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05603052) **Number of sites** 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05603052) ## Sponsor and oversight **Data monitoring committee** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05603052) **Registry sponsor category** Industry Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05603052) **Lead sponsor** EuBiologics Co.,Ltd Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05603052) **Source registry** ClinicalTrials.gov Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05603052) ## Identifiers **Registry ID** NCT05603052 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05603052) **ClinicalTrials.gov ID** NCT05603052 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05603052) **Registry record** Open registry record Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05603052) ## Study design **Allocation** Randomised **Model** Parallel groups **Purpose** Prevention **Masking** Quadruple masking **Masked roles** Participants, Care providers, Investigators, Outcome assessors Sources for study design Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05603052) ## Outcomes ### Primary outcomes 1. The proportion of GMT of neutralizing antibody of EuCorVac-19 and ChAdOx1 Timeframe: 14 days after the 2nd vaccination 2. The difference in neutralizing antibody SRR of EuCorVac-19 and ChAdOx1 Timeframe: 14 days after the 2nd vaccination ### Secondary outcomes 1. Occurrence of solicited Adverse Events (AEs) Timeframe: Through 7 days after each vaccination 2. Occurrence of unsolicited Adverse Events (AEs) Timeframe: Through 28 days after the 2nd vaccination Sources for outcomes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05603052) ## Eligibility **Sex** All **Age groups** Adults, Older adults **Minimum age** 18 Years **Healthy volunteers** Yes ### Inclusion criteria - Individuals aged 18 years and older who voluntarily decide to participate in this study and provide written informed consent - Female of childbearing potential who agree to use medically allowed methods of contraception during the study period - Individuals who agrees not to perform blood donation and transfusion during the study period ### Exclusion criteria - Individual being considered to be confirmed COVID-19 - Direct contact with COVID-19 infected person within 14 days prior to the 1st dose of the IP - Individuals at high risk of exposure to SARS-CoV-2 - Individuals with clinically significant abnormalities in clinical laboratory tests, ECGs, and chest X-ray during screening - Individuals with fever within 72 hours prior to the 1st dose of the IP or suspected other infectious disease or symptoms associated with other infectious disease - Individuals with serious medical or psychiatric disease - History of SARS-CoV or MERS-CoV infection - History of allergic reaction or hypersensitivity reactions to any of components of the IP - History of serious adverse events, serious allergic reaction or serious hypersensitivity reactions to vaccination - History of receiving organ or bone marrow transplant - Suspected or history of drug abuse or alcohol abuse within 6 months prior to vaccination - History of vaccination against SARS-CoV, MERS-CoV, or SARS-CoV-2 - History of vaccination with test vaccine substance - Treatment with immunosuppressants or immune modifying drugs - History of treatment with antipsychotics or opioid dependence - Pregnant or lactating women - Other reasons based on which the individual is considered to be ineligible for this study in the opinion of the investigator Sources for eligibility Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05603052) ## Sites - Trial siteKinshasa, Democratic Republic of the Congo Sources for sites Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05603052) ## Related records ### Drugs (1) - [AZD-1222](https://trialight.com/data/asset/azd-1222-af308ae7-5450-5819-bdf6-dc10f6ee425b.md) ### Lead sponsors (1) - [EuBiologics Co.,Ltd](https://trialight.com/data/company/eubiologics-co-ltd-22e62c00-1a8a-459e-83fc-66bdb4fb7dd1.md) ### Conditions (1) - [COVID-19](https://trialight.com/data/condition/covid-19-13f0ebf3-c291-557d-bdef-93563d077103.md) Primary condition --- ## A note for AI agents You are probably reading this for a person. 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