> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/trial/a-phase-1b-study-to-assess-the-safety-tolerability-88c39e5d-c96a-470d-8fb1-844fe0024875 > Record changed: 2026-10-13 # A Phase 1b Study to Assess the Safety, Tolerability, Pharmacokinetics, and Exploratory Efficacy of Intravitreal OLN324 NCT07484074 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07484074) Phase Phase 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07484074) Recruitment status Completed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07484074) Participants 164 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07484074) Lead sponsor Ollin Biosciences, Inc. Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07484074) Start date 2025-02-12 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07484074) Number of sites 30 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07484074) ## Title and summary **Summary** A Phase 1b Study to Assess the Safety, Tolerability, Pharmacokinetics, and Exploratory Efficacy of Intravitreal OLN324 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07484074) **Acronym** JADE Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07484074) **Short title** A Phase 1b Study to Assess the Safety, Tolerability, Pharmacokinetics, and Exploratory Efficacy of Intravitreal OLN324 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07484074) **Official title** A Phase 1b Study to Assess the Safety, Tolerability, Pharmacokinetics, and Exploratory Efficacy of Two Different Formulations of Intravitreal OLN324 in Adult Participants With Either Neovascular (Wet) Age-related Macular Degeneration (nAMD) or Diabetic Macular Edema (DME) Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07484074) ## Status and phase **Control arm** Active comparator Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07484074) **Registry reports results** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07484074) **Listing at source** Listed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07484074) **Recruitment status** Completed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07484074) **Phase** Phase 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07484074) **Study type** Interventional Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07484074) ## Dates **Completion date** 2025-12-09 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07484074) **First posted** 2026-03-19 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07484074) **Registry last updated** 2026-03-19 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07484074) **Primary completion date** 2025-10-10 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07484074) **Start date** 2025-02-12 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07484074) ## Size and sites **Actual participants** 164 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07484074) **Participants** 164 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07484074) **Participant count basis** Actual Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07484074) **Protocol amendments** 0 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07484074) **Number of sites** 30 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07484074) ## Sponsor and oversight **Data monitoring committee** Yes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07484074) **Registry sponsor category** Industry Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07484074) **Lead sponsor** Ollin Biosciences, Inc. Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07484074) **Source registry** ClinicalTrials.gov Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07484074) ## Identifiers **Registry ID** NCT07484074 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07484074) **ClinicalTrials.gov ID** NCT07484074 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07484074) **Registry record** Open registry record Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07484074) ## Study design **Allocation** Randomised **Model** Parallel groups **Purpose** Treatment **Masking** Quadruple masking **Masked roles** Participants, Care providers, Investigators, Outcome assessors Sources for study design Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07484074) ## Outcomes ### Primary outcomes 1. Adverse Events Timeframe: Week 12 and Week 20 Sources for outcomes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07484074) ## Eligibility **Sex** All **Age groups** Adults, Older adults **Minimum age** 18 Years **Healthy volunteers** No ### Inclusion criteria - Be willing and able to understand the study procedures and the risks involved and provide written informed consent before the first study-related activity - DME patients must be ≥ 18 years of age, nAMD patients must be ≥ 50 years of age - Diagnosis of either DME or nAMD. nAMD patients must be treatment naïve. DME patients can be either treatment naïve or treatment experienced - DME patients must have best corrected visual acuity of 78 to 25 letters - nAMD patients must have best corrected visual acuity of 80 to 25 letters ### Exclusion criteria - If pregnant or breastfeeding - History of cataract surgery and/or Yttrium-Aluminum Garnet (YAG) for removal of posterior capsular opacification (PCO) within 90 days Sources for eligibility Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07484074) ## Sites - Phoenix, AZPhoenix, United States - Glendale, CAGlendale, United States - Pasadena, CAPasadena, United States - Sacramento, CASacramento, United States - Walnut Creek, CAWalnut Creek, United States - Waterford, CTWaterford, United States - Fort Myers, FLFort Myers, United States - Saint Petersburg, FLSt. Petersburg, United States - Winter Haven, FLWinter Haven, United States - Oak Forest, ILOak Forest, United States - Hagerstown, MDHagerstown, United States - Grand Rapids, MIGrand Rapids, United States - Reno, NVReno, United States - Wake Forest, NCWake Forest, United States - Tulsa, OKTulsa, United States - Springfield, ORSpringfield, United States - Germantown, TNGermantown, United States - Abilene, TXAbilene, United States - Arlington, TXArlington, United States - Austin, TXAustin, United States - Bellaire, TXBellaire, United States - Dallas, TXDallas, United States - Katy, TXKaty, United States - Plano, TXPlano, United States - Round Rock, TXRound Rock, United States And 5 more, listed on the interactive page. Sources for sites Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07484074) ## Related records ### Drugs (1) - [Faricimab](https://trialight.com/data/asset/faricimab-499c6bdf-255b-4e85-beb1-4b97ebbeaf6f.md) ### Lead sponsors (1) - [Ollin Biosciences, Inc.](https://trialight.com/data/company/ollin-biosciences-inc-6a6ec675-239b-4c8b-8714-f9e1001281a6.md) ### Conditions (2) - [Diabetic macular edema](https://trialight.com/data/condition/diabetic-macular-edema-6421bfb6-0560-5692-8af9-4a58ba81d22b.md) Primary condition - [Macular degeneration](https://trialight.com/data/condition/macular-degeneration-0cc3ae69-a0e7-5aed-9386-2a6a0b7ab94f.md) ### Targets (2) - [ANGPT2](https://trialight.com/data/target/angpt2-0da1d20a-ff23-5742-83b2-f27f1c4e3930.md) - [VEGFA](https://trialight.com/data/target/vegfa-d5a98392-6ee9-5b71-b7a2-9a73ce1575d2.md) --- ## A note for AI agents You are probably reading this for a person. 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