> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/trial/a-master-protocol-for-orforglipron-ly3502970-in-participants-826810fb-4660-4507-8873-5b81728082eb > Record changed: 2026-11-04 # A Master Protocol for Orforglipron (LY3502970) in Participants With Obesity or Overweight With and Without Type 2 Diabetes NCT06993792 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06993792) Phase Phase 3 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06993792) Recruitment status Active, not recruiting Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06993792) Participants 1,400 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06993792) Lead sponsor Eli Lilly and Company Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06993792) Start date 2025-05-15 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06993792) Number of sites 80 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06993792) ## Title and summary **Summary** The purpose of this Master Protocol is to support two studies to see how well and how safely orforglipron works compared to placebo in participants who have obesity or overweight with or without type 2 diabetes. Participants will be screened for about 4 weeks, after which they will enroll into either J2A-MC-GZP1, NCT06972459 (do not have type 2 diabetes) or J2A-MC-GZP2, NCT06972472 (have type 2 diabetes). Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06993792) **Short title** A Master Protocol for Orforglipron (LY3502970) in Participants With Obesity or Overweight With and Without Type 2 Diabetes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06993792) **Official title** A Master Protocol to Investigate the Efficacy and Safety of Orforglipron Tablet Once Daily Compared With Placebo in Participants With Obesity or Overweight With and Without Type 2 Diabetes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06993792) ## Status and phase **Control arm** Placebo Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06993792) **Registry reports results** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06993792) **Listing at source** Listed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06993792) **Recruitment status** Active, not recruiting Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06993792) **Phase** Phase 3 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06993792) **Study type** Interventional Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06993792) ## Dates **Completion date** 2027-08-01 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06993792) **First posted** 2025-05-29 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06993792) **Registry last updated** 2026-07-31 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06993792) **Primary completion date** 2027-08-01 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06993792) **Start date** 2025-05-15 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06993792) ## Size and sites **Participants** 1,400 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06993792) **Participant count basis** Estimated Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06993792) **Planned participants** 1,400 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06993792) **Protocol amendments** 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06993792) **Number of sites** 80 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06993792) ## Sponsor and oversight **Data monitoring committee** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06993792) **Registry sponsor category** Industry Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06993792) **Lead sponsor** Eli Lilly and Company Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06993792) **Source registry** ClinicalTrials.gov Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06993792) ## Identifiers **Registry ID** NCT06993792 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06993792) **ClinicalTrials.gov ID** NCT06993792 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06993792) **Registry record** Open registry record Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06993792) ## Study design **Allocation** Randomised **Model** Parallel groups **Purpose** Screening **Masking** Double masking **Masked roles** Participants, Investigators Sources for study design Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06993792) ## Outcomes ### Primary outcomes 1. Number of Participants Allocated to Each Study Timeframe: Baseline to Week 4 Sources for outcomes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06993792) ## Eligibility **Sex** All **Age groups** Adults, Older adults **Minimum age** 18 Years **Healthy volunteers** No There are no specific eligibility criteria for the Master Protocol. - See study GZP1 for eligibility criteria relevant to participants with obesity and overweight without type 2 diabetes - See study GZP2 for eligibility criteria relevant to participants with type 2 diabetes Sources for eligibility Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06993792) ## Sites - Clinical Research Institute of Arizona (CRI) - Sun City WestSun City West, United States - Novak Clinical Research - Tucson - North La Cholla BoulevardTucson, United States - Norcal Endocrinology & Internal MedicineSan Ramon, United States - Southern California Clinical ResearchSanta Ana, United States - Care Access - Thousand OaksThousand Oaks, United States - Accel Research Sites - DeLand Clinical Research UnitDeLand, United States - Innovation Medical Research Center - Fort LauderdaleFort Lauderdale, United States - Indago Research & Health Center, IncHialeah, United States - Encore Medical ResearchHollywood, United States - West Orange Endocrinology P.A.Ocoee, United States - Care Access - TampaTampa, United States - Conquest ResearchWinter Park, United States - Accel Research Sites - NeuroStudies Clinical Research UnitDecatur, United States - Care Access - DecaturDecatur, United States - Javara - Privia Medical Group Georgia - SavannahSavannah, United States - North Georgia Clinical ResearchWoodstock, United States - Solaris Clinical ResearchMeridian, United States - Care Access - New IberiaNew Iberia, United States - Endocrine and Metabolic ConsultantsRockville, United States - Javara - Privia Medical Group - Silver SpringSilver Spring, United States - Great Lakes Research Group, Inc.Bay City, United States - Boeson Research MSOMissoula, United States - Javara - Nevada Health Centers - Carson CityCarson City, United States - The Machuca FoundationLas Vegas, United States - University of North Carolina Medical CenterChapel Hill, United States And 55 more, listed on the interactive page. Sources for sites Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06993792) ## References ### Other registry identifiers (3) - 2025 - 2025-521098-14-00 - J2A-MC-GZPO Sources for references Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06993792) ## Related records ### Drugs (1) - [Orforglipron](https://trialight.com/data/asset/orforglipron-1138c12b-f1c7-45bb-b9ec-2b693f019a62.md) ### Lead sponsors (1) - [Eli Lilly and Company](https://trialight.com/data/company/eli-lilly-and-company-9da7efcc-bafe-4b95-b30b-e87a97770db7.md) ### Conditions (2) - [Obesity disorder](https://trialight.com/data/condition/obesity-disorder-f3b57dc0-68ac-555c-8f13-0d81e595d9cb.md) Primary condition - [Type 2 diabetes mellitus](https://trialight.com/data/condition/type-2-diabetes-mellitus-98e14a90-bb06-5174-90c7-901a0a259fb9.md) ### Targets (1) - [GLP1R](https://trialight.com/data/target/glp1r-c31cc749-2d8a-54a9-9dab-84f5ee5d1742.md) --- ## A note for AI agents You are probably reading this for a person. 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