> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/trial/a-long-term-extension-study-of-imvt-1402-in-adult-d92b6981-ac71-4808-9a1d-7fe488b3185d > Record changed: 2026-11-04 # A Long-Term Extension Study of IMVT-1402 in Adult Participants With Graves' Disease (GD) NCT07286006 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07286006) Phase Phase 2 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07286006) Recruitment status Enrolling by invitation Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07286006) Participants 372 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07286006) Lead sponsor Immunovant Sciences GmbH Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07286006) Start date 2026-01-26 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07286006) Number of sites 131 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07286006) ## Title and summary **Summary** This is a long-term extension study that will rollover participants completing feeder studies IMVT-1402-2502 (NCT06727604) or IMVT-1402-2503 (NCT07018323) to evaluate the efficacy and safety of IMVT-1402 in adult participants with GD. Eligible participants will be assigned to 1 of 3 study groups (Groups A, B and C) based on their GD status at the completion of their respective feeder study. Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07286006) **Short title** A Long-Term Extension Study of IMVT-1402 in Adult Participants With Graves' Disease (GD) Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07286006) **Official title** A Long-Term Extension Study to Assess the Efficacy, Safety, and Tolerability of IMVT-1402 in Adult Patients With Graves' Disease Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07286006) ## Status and phase **Control arm** Open label Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07286006) **Registry reports results** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07286006) **Listing at source** Listed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07286006) **Recruitment status** Enrolling by invitation Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07286006) **Phase** Phase 2 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07286006) **Study type** Interventional Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07286006) ## Dates **Completion date** 2030-03-01 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07286006) **First posted** 2025-12-16 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07286006) **Registry last updated** 2026-09-29 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07286006) **Primary completion date** 2030-03-01 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07286006) **Start date** 2026-01-26 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07286006) ## Size and sites **Participants** 372 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07286006) **Participant count basis** Estimated Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07286006) **Planned participants** 372 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07286006) **Protocol amendments** 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07286006) **Number of sites** 131 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07286006) ## Sponsor and oversight **Data monitoring committee** Yes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07286006) **Registry sponsor category** Industry Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07286006) **Lead sponsor** Immunovant Sciences GmbH Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07286006) **Source registry** ClinicalTrials.gov Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07286006) ## Identifiers **Registry ID** NCT07286006 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07286006) **ClinicalTrials.gov ID** NCT07286006 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07286006) **Registry record** Open registry record Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07286006) ## Study design **Allocation** Not randomised **Model** Parallel groups **Purpose** Treatment **Masking** No masking Sources for study design Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07286006) ## Outcomes ### Primary outcomes 1. Percentage of Group A Participants who remain euthyroid, Off ATD, and Off IMVT-1402 Timeframe: At Week 52 ### Secondary outcomes 1. Percentage of Group A Participants who are euthyroid and off ATD Timeframe: At Week 26 2. Percentage of Group A Participants who are euthyroid and off ATD Timeframe: Up to Week 52 3. Percentage of Group A Participants who are euthyroid, off ATD, and off IMVT-1402 Timeframe: Up to Week 52 4. Time to earliest date of euthyroidism, off ATD, and off IMVT-1402 to the earliest date of confirmed relapse in Group A Participants Timeframe: Up to Week 52 5. Percentage of Group B Participants who remain euthyroid, off ATD, and off IMVT-1402 Timeframe: Up to Week 52 6. Percentage of Group B Participants who remain euthyroid, off ATD, and off IMVT-1402 Timeframe: At Week 52 7. Time from Week 0 to the earliest date of confirmed relapse in Group B Participants Timeframe: Up to Week 52 8. Percentage of Group C Participants who remain euthyroid, off ATD, and off IMVT-1402 Timeframe: Up to Week 52 9. Percentage of Group C Participants who remain euthyroid, off ATD, and off IMVT-1402 Timeframe: At Week 52 10. Time From Week 0 to the earliest date of confirmed relapse in Group C Participants Timeframe: Up to Week 52 11. Percentage of Group A Participants who are euthyroid, off ATD, and seronegative for TRAb Timeframe: At Week 26 12. Percentage of Group A Participants who are euthyroid, off ATD, and seronegative for TRAb Timeframe: Up to Week 52 Sources for outcomes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07286006) ## Eligibility **Sex** All **Age groups** Adults, Older adults **Minimum age** 18 Years **Healthy volunteers** No ### Inclusion criteria - Participants who completed Study IMVT-1402-2502 or Study IMVT-1402-2503. - Other, more specific inclusion criteria are defined in the protocol. ### Exclusion criteria - Have permanently discontinued IMP during the treatment period in the feeder study or have met study stopping criteria at any point up until the end of participation in the feeder study. Sources for eligibility Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07286006) ## Sites - Site Number - 1561Phoenix, United States - Site Number - 1519Phoenix, United States - Site Number - 1530Tucson, United States - Site Number - 1510Concord, United States - Site Number - 1587Huntington Beach, United States - Site Number - 1554Los Angeles, United States - Site Number - 1588Orange, United States - Site Number - 1559San Francisco, United States - Site Number - 1558Santa Clarita, United States - Site Number - 1552Torrance, United States - Site Number - 1533Aurora, United States - Site Number -1514Englewood, United States - Site Number - 1516Newark, United States - Site Number - 1567Washington D.C., United States - Site Number - 1556Clearwater, United States - Site Number - 1522Doral, United States - Site Number - 1523Hialeah, United States - Site Number - 1581Jacksonville, United States - Site Number - 1582Jacksonville, United States - Site Number - 1505Miami, United States - Site Number - 1564Miami, United States - Site Number - 1591Miami, United States - Site Number - 1590Ocoee, United States - Site Number - 1508Orlando, United States - Site Number - 1507Port Charlotte, United States And 106 more, listed on the interactive page. Sources for sites Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07286006) ## Related records ### Drugs (1) - [Imeroprubart](https://trialight.com/data/asset/imeroprubart-81781f97-2af3-41d6-8dae-65c6678e474b.md) ### Lead sponsors (1) - [Immunovant Sciences GmbH](https://trialight.com/data/company/immunovant-sciences-gmbh-db27c1eb-3608-4b4d-b11a-0bde6e8f7dea.md) ### Conditions (1) - [Graves disease](https://trialight.com/data/condition/graves-disease-67add423-de79-5c4c-ad2c-cbc80852cd64.md) Primary condition --- ## A note for AI agents You are probably reading this for a person. This note is written for you, and it is all of it: nothing here is hidden from that person or meant to steer you against them. - Cite this page with its date. Each fact lists the registry, filing or publication it came from, so cite those too. - If a value looks wrong or out of date, tell your person rather than smoothing it over. 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