> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/trial/a-first-in-human-research-study-on-how-nnc0721-8060-works-in-7a55472a-edcc-4dea-9cc0-6cb51917896e > Record changed: 2026-11-04 # A First-in-human Research Study on How NNC0721-8060 Works in People Living With Overweight or Obesity NCT07767175 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07767175) Phase Phase 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07767175) Recruitment status Recruiting Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07767175) Participants 142 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07767175) Lead sponsor Novo Nordisk A/S Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07767175) Start date 2026-08-12 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07767175) Number of sites 2 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07767175) ## Title and summary **Summary** The purpose of the study is to find out if NNC0721-8060 is safe and how it works in people living with overweight or obesity. Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07767175) **Short title** A First-in-human Research Study on How NNC0721-8060 Works in People Living With Overweight or Obesity Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07767175) **Official title** A Study Investigating Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of NNC0721-8060 in Healthy Adult Participants Living With Overweight or Obesity Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07767175) ## Status and phase **Control arm** Placebo Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07767175) **Registry reports results** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07767175) **Listing at source** Listed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07767175) **Recruitment status** Recruiting Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07767175) **Phase** Phase 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07767175) **Study type** Interventional Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07767175) ## Dates **Completion date** 2027-09-23 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07767175) **First posted** 2026-08-17 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07767175) **Registry last updated** 2026-09-04 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07767175) **Primary completion date** 2027-09-23 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07767175) **Start date** 2026-08-12 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07767175) ## Size and sites **Participants** 142 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07767175) **Participant count basis** Estimated Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07767175) **Planned participants** 142 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07767175) **Protocol amendments** 0 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07767175) **Number of sites** 2 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07767175) ## Sponsor and oversight **Data monitoring committee** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07767175) **Registry sponsor category** Industry Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07767175) **Lead sponsor** Novo Nordisk A/S Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07767175) **Source registry** ClinicalTrials.gov Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07767175) ## Identifiers **Registry ID** NCT07767175 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07767175) **ClinicalTrials.gov ID** NCT07767175 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07767175) **Registry record** Open registry record Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07767175) ## Study design **Allocation** Randomised **Model** Parallel groups **Purpose** Treatment **Masking** Double masking **Masking description** Sponsor staff involved in the clinical trial is masked according to company standard procedures. **Masked roles** Participants, Investigators Sources for study design Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07767175) ## Outcomes ### Primary outcomes 1. Part A: Number of treatment emergent adverse events (TEAE) Timeframe: From Day 1 to Day 36 Measured as number of events. 2. Part B: Number of treatment emergent adverse events (TEAE) Timeframe: From Day 1 to Day 57 Measured as number of events. 3. Part C: Change from baseline in body weight Timeframe: From Day 1 to Day 85 Measured as percentage change in body weight. ### Secondary outcomes 1. Part A: AUC- Area under the NNC0721-8060 plasma concentration time-curve Timeframe: From Day 1 to Day 36 Measured as hour nanomoles per litre (h\\\*nmol/L). 2. Part A: Cmax- Maximum observed plasma concentration of NNC0721-8060 Timeframe: From Day 1 to Day 36 Measured as nanomoles per litre (nmol/L). 3. Part B: AUC- Area under the NNC0721-8060 plasma concentration time-curve Timeframe: From Day 1 to Day 57 Measured as h\\\*nmol/L. 4. Part B: Cmax- Maximum observed plasma concentration of NNC0721-8060 Timeframe: From Day 1 to Day 57 Measured as nmol/L. 5. Part C: AUC- Area under the NNC0721-8060 plasma concentration time-curve Timeframe: From Day 1 to Day 113 Measured as h\\\*nmol/L. 6. Part C: Cmax- Maximum observed plasma concentration of NNC0721-8060 Timeframe: From Day 1 to Day 113 Measured as nmol/L. 7. Part C: Number of treatment emergent adverse events (TEAE) Timeframe: From Day 1 to Day 113 Measured as number of events. Sources for outcomes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07767175) ## Eligibility **Sex** All **Age groups** Adults **Minimum age** 18 Years **Maximum age** 55 Years **Healthy volunteers** Yes ### Inclusion criteria - Male or female (sex at birth). - Age 18-55 years (both inclusive) at the time of signing informed consent. - Body Mass Index (BMI) 27.0-34.9 kilograms per square metre (kg/m^2) (both inclusive) at screening, with overweight due to excess adipose tissue as judged by the investigator. - Considered eligible based on medical history, physical examination, vital signs, electrocardiogram and clinical laboratory tests at screening, as judged by the investigator. ### Exclusion criteria - Known or suspected hypersensitivity to study intervention(s) or related products. - Previous randomisation in this study. - History of allergies (with the exception of seasonal allergies) or history of anaphylactic reactions. - Female who is pregnant, breastfeeding, intends to become pregnant, or is of childbearing potential and not using adequate contraception. - Current participation (signed informed consent) in any other interventional clinical study. - Exposure to an investigational medicinal product within 30 days or five half-lives of that product (whichever is longer) before screening. - Any disorder, unwillingness or inability which, in the investigator's opinion, might jeopardise participant safety or compliance with the protocol. - Glycated haemoglobin (HbA1c) greater than or equal to (≥) 6.5 percentage (%) (48 millimoles per mole \[mmol/mol\]) at screening. Sources for eligibility Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07767175) ## Sites - ICON Early Phase Services, LLCLenexa, United StatesRecruiting - ICONSan Antonio, United StatesNot yet recruiting Sources for sites Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07767175) ## References ### Other registry identifiers - U1111-1334-3077 Sources for references Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07767175) ## Related records ### Drugs (1) - [Semaglutide](https://trialight.com/data/asset/semaglutide-0f0980aa-d386-4209-8f14-80da83c40d80.md) ### Lead sponsors (1) - [Novo Nordisk A/S](https://trialight.com/data/company/novo-nordisk-a-s-35a80f1a-9ef6-4057-99c1-6ab497939195.md) ### Conditions (1) - [Obesity disorder](https://trialight.com/data/condition/obesity-disorder-f3b57dc0-68ac-555c-8f13-0d81e595d9cb.md) ### Targets (1) - [GLP1R](https://trialight.com/data/target/glp1r-c31cc749-2d8a-54a9-9dab-84f5ee5d1742.md) --- ## A note for AI agents You are probably reading this for a person. 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