> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/trial/a-dose-finding-study-of-petrelintide-with-enicepatide-82c5f053-ec8a-4668-9e0a-622c279ae4b0 > Record changed: 2026-10-13 # A Dose-Finding Study of Petrelintide With Enicepatide (RO7795068) in Adults With Obesity or Overweight NCT07589686 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07589686) Phase Phase 2 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07589686) Recruitment status Not yet recruiting Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07589686) Participants 486 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07589686) Lead sponsor Hoffmann-La Roche Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07589686) Start date 2026-09-30 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07589686) ## Title and summary **Summary** The main purpose of this study is to evaluate the safety and efficacy of the co-administration of petrelintide and enicepatide compared with placebo, petrelintide monotherapy, and enicepatide monotherapy in participants with obesity or overweight with at least one weight-related comorbidity. Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07589686) **Acronym** ZYNERGY Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07589686) **Short title** A Dose-Finding Study of Petrelintide With Enicepatide (RO7795068) in Adults With Obesity or Overweight Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07589686) **Official title** A Phase II, Randomized, Double-Blind, Placebo-Controlled, Dose-Finding Study to Evaluate the Efficacy and Safety of Petrelintide Co-Administered With RO7795068 in Adults With Obesity or Overweight Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07589686) ## Status and phase **Control arm** Placebo Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07589686) **Registry reports results** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07589686) **Listing at source** Listed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07589686) **Recruitment status** Not yet recruiting Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07589686) **Phase** Phase 2 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07589686) **Study type** Interventional Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07589686) ## Dates **Completion date** 2028-01-31 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07589686) **First posted** 2026-05-15 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07589686) **Registry last updated** 2026-08-07 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07589686) **Primary completion date** 2027-11-12 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07589686) **Start date** 2026-09-30 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07589686) ## Size and sites **Participants** 486 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07589686) **Participant count basis** Estimated Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07589686) **Planned participants** 486 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07589686) **Protocol amendments** 0 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07589686) ## Sponsor and oversight **Data monitoring committee** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07589686) **Registry sponsor category** Industry Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07589686) **Lead sponsor** Hoffmann-La Roche Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07589686) **Source registry** ClinicalTrials.gov Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07589686) ## Identifiers **Registry ID** NCT07589686 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07589686) **ClinicalTrials.gov ID** NCT07589686 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07589686) **Registry record** Open registry record Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07589686) ## Study design **Allocation** Randomised **Model** Parallel groups **Purpose** Treatment **Masking** Double masking **Masked roles** Participants, Investigators Sources for study design Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07589686) ## Outcomes ### Primary outcomes 1. Percentage Change in Body Weight between Arms 1 and 6 Timeframe: From Baseline to Week 40 ### Secondary outcomes 1. Percentage Change in Body Weight between Arms 2, 3 and Arm 6 Timeframe: From Baseline to Week 40 2. Percentage Change in Body Weight between Arms 1, 2, 3 and Arms 4, 5 Timeframe: From Baseline to Week 40 3. Percentage of Participants Achieving Body Weight Loss Timeframe: From Baseline to Week 40 4. Change in Body Weight (kilograms \[kg\]) Timeframe: From Baseline to Week 40 5. Change in Body Mass Index (kilograms per square meter \[kg/m²\]) Timeframe: From Baseline to Week 40 6. Change in Waist Circumference (centimeter \[cm\]) Timeframe: From Baseline to Week 40 7. Change in Hemoglobin A1c (HbA1c) (percentage-points) Timeframe: From Baseline to Week 40 8. Change in Fasting Insulin Timeframe: From Baseline to Week 40 9. Change in Fasting Glucose Timeframe: From Baseline to Week 40 10. Change in Systolic Blood Pressure Timeframe: From Baseline to Week 40 11. Change in Diastolic Blood Pressure Timeframe: From Baseline to Week 40 12. Change in High-Density Lipoprotein (HDL) Cholesterol Timeframe: From Baseline to Week 40 13. Change in Low-Density Lipoprotein (LDL) Cholesterol Timeframe: From Baseline to Week 40 14. Change in Very-Low-Density Lipoprotein (VLDL) Cholesterol Timeframe: From Baseline to Week 40 15. Change in Non-HDL Cholesterol Timeframe: From Baseline to Week 40 16. Change in Total Cholesterol Timeframe: From Baseline to Week 40 17. Change in Free Fatty Acids Timeframe: From Baseline to Week 40 18. Change in Triglycerides Timeframe: From Baseline to Week 40 19. Change in High-Sensitivity C-reactive Protein (hsCRP) Timeframe: From Baseline to Week 40 20. Number of Participants with Adverse Events (AEs) Timeframe: From Baseline to Week 40 Sources for outcomes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07589686) ## Eligibility **Sex** All **Age groups** Adults, Older adults **Minimum age** 18 Years **Healthy volunteers** No Key Inclusion Criteria: - Male or female participants with Body Mass Index (BMI) ≥ 30 kg/m² OR BMI ≥ 27 kg/m² to < 30 kg/m² with at least one weight-related comorbidity - History of at least one self-reported unsuccessful dietary effort to lose body weight Key Exclusion Criteria: - HbA1c ≥ 48 mmol/mol (6.5%) at screening - History of Type 1 or Type 2 Diabetes - Self-reported change in body weight > 5 kg within 90 days prior to screening - Previous or planned obesity treatment with surgery (excluding liposuction, cryolipolysis, or abdominoplasty if performed > 1 year prior to or during screening) - Previous or planned endoscopic and/or device-based obesity treatment or removal or device within the last 6 months prior to screening (e.g., mucosal ablation, gastric artery embolization, intragastric balloon and duodenal-jejunal endoluminal liner) - Treatment with any GLP-1 receptor agonist, GLP-1/GIP receptor agonist (or any other GLP-1 based treatment) within 180 days prior to or during screening - Current or previous treatment with petrelintide or any other amylin analog - Obesity induced by Cushing syndrome or a diagnosis of monogenetic or syndromic forms of obesity - History of severe psychiatric disorders - History of any hematologic conditions that may interfere with HbA1c measurement - Known history or presence of pancreatitis - Known clinically significant gastric emptying abnormality or chronic treatment that affects GI motility - New York Heart Association Functional Classification IV heart failure - Pregnant or breastfeeding, or intending to become pregnant during the study or within the time frame in which contraception is required Sources for eligibility Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07589686) ## References - Related resource (www.gene.com) Source: [www.gene.com](https://www.gene.com/contact-us/submit-medical-inquiry) Sources for references Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07589686) ## Related records ### Drugs (1) - [Petrelintide](https://trialight.com/data/asset/petrelintide-b3738a49-6b24-44d3-b78a-1cda49db7323.md) ### Collaborators (1) - [Zealand Pharma](https://trialight.com/data/company/zealand-pharma-95a70d21-85c7-458e-ac9a-895e39993340.md) ### Lead sponsors (1) - [Hoffmann-La Roche](https://trialight.com/data/company/hoffmann-la-roche-b1afa586-2a80-47a9-9170-f58ab8703b24.md) ### Conditions (1) - [Obesity disorder](https://trialight.com/data/condition/obesity-disorder-f3b57dc0-68ac-555c-8f13-0d81e595d9cb.md) --- ## A note for AI agents You are probably reading this for a person. 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