> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/trial/a-104-week-study-of-ritlecitinib-oral-capsules-in-adults-ff919ca0-6ace-45c1-b983-750c0c3cc811 > Record changed: 2026-10-13 # A 104-Week Study of Ritlecitinib Oral Capsules in Adults With Nonsegmental Vitiligo (Active and Stable) Tranquillo 2 NCT06072183 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06072183) Phase Phase 3 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06072183) Recruitment status Active, not recruiting Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06072183) Participants 1,571 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06072183) Lead sponsor Pfizer Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06072183) Start date 2023-11-08 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06072183) Number of sites 229 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06072183) ## Title and summary **Summary** The purpose of this study is to learn about the safety and effects of the study medicine ritlecitinib for the possible treatment of nonsegmental vitiligo. Vitiligo causes white patches on your skin when the cells that give your skin color are destroyed. Nonsegmental means that it can affect both sides of the body such as both knees and both hands. Ritlecitinib has been tested in earlier clinical studies and has a favorable safety profile. At present there are no approved medications taken by mouth to treat nonsegmental vitiligo. This study is seeking participants who: \* Are 18 years of age or older. \* are confirmed to have nonsegmental vitiligo for at least 3 months. \* Are willing to stop all other treatments that they may be taking for vitiligo. In this study participants will be chosen by chance, like drawing names out of a hat to receive 1 of 3 treatments: •Part I where two different amounts of ritlecitinib (50 mg and 100 mg) are taken once daily. It will be compared to placebo. Placebo is a dummy capsule. It doesn't have any medicine used in the study. Participants receiving placebo who have not responded to treatment after 52 weeks will be given 100 milligrams or 50 milligrams of ritlecitinib for the remaining 52 weeks of the study. • In Part II, participants will only receive 100 milligrams of ritlecitinib. About 1000 participants will take part in Part I and around 450 in Part II globally. The study will compare the experiences of people receiving ritlecitinib to those of the people who do not. This will help see if ritlecitinib is safe and effective. People in Part I will be in this study for about 26 months and people in Part II will be in this study for about 14 months. During the study, participants in part I will need to visit the study site at least 17 times. In part II, participants will visit at least 11 times. Participants will undergo various tests and procedures such as: \* vitiligo rating, \* physical examinations, \* hearing tests, \* blood tests, \* x-ray, \* ECG, \* photographs of areas with vitiligo. Participants will be asked to complete questionnaires about their vitiligo. Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06072183) **Acronym** Tranquillo 2 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06072183) **Short title** A 104-Week Study of Ritlecitinib Oral Capsules in Adults With Nonsegmental Vitiligo (Active and Stable) Tranquillo 2 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06072183) **Official title** A PHASE 3 RANDOMIZED, DOUBLE-BLIND, 52-WEEK PLACEBO-CONTROLLED MULTI-CENTER STUDY WITH A DOUBLE-BLIND 52-WEEK EXTENSION PERIOD WITH RANDOMIZED DOSE UP/DOSE DOWN TITRATION INVESTIGATING THE EFFICACY, SAFETY, AND TOLERABILITY OF RITLECITINIB IN ADULT PARTICIPANTS WITH NONSEGMENTAL VITILIGO Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06072183) ## Status and phase **Control arm** Placebo Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06072183) **Registry reports results** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06072183) **Listing at source** Listed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06072183) **Recruitment status** Active, not recruiting Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06072183) **Phase** Phase 3 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06072183) **Study type** Interventional Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06072183) ## Dates **Completion date** 2027-07-30 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06072183) **First posted** 2023-10-10 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06072183) **Registry last updated** 2026-06-24 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06072183) **Primary completion date** 2027-07-30 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06072183) **Start date** 2023-11-08 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06072183) ## Size and sites **Actual participants** 1,571 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06072183) **Participants** 1,571 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06072183) **Participant count basis** Actual Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06072183) **Protocol amendments** 3 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06072183) **Number of sites** 229 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06072183) ## Sponsor and oversight **Data monitoring committee** Yes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06072183) **Registry sponsor category** Industry Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06072183) **Lead sponsor** Pfizer Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06072183) **Source registry** ClinicalTrials.gov Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06072183) ## Identifiers **Registry ID** NCT06072183 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06072183) **ClinicalTrials.gov ID** NCT06072183 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06072183) **Registry record** Open registry record Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06072183) ## Study design **Allocation** Randomised **Model** Parallel groups **Purpose** Treatment **Masking** Quadruple masking **Masked roles** Participants, Care providers, Investigators, Outcome assessors Sources for study design Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06072183) ## Outcomes ### Primary outcomes 1. US only Co-Primary Endpoints: Response based on Facial Vitiligo Area Scoring Index 75 (F-VASI75) at Week 52 and Total body Vitiligo Area Scoring Index 50 (T-VASI50) at Week 52 Timeframe: 52 Weeks Proportion of participants achieving F-VASI75 (defined as at least 75% improvement in F-VASI from Baseline) and T-VASI50 (defined as at least 50% improvement in T-VASI from Baseline) 2. Global (Other than US): Response based on Facial Vitiligo Area Scoring Index 75 (F-VASI75) at Week 52 Timeframe: 52 Weeks Proportion of participants achieving F-VASI75 (defined as at least 75% improvement in F-VASI from Baseline). 3. Incidence of Treatment Emergent Adverse Events (TEAEs), Serious Adverse Events (SAEs) and Adverse Events (AEs) leading to discontinuation. Timeframe: Baseline through 108 weeks To evaluate the safety and tolerability of ritlecitinib in adult participants with non segmental vitiligo 4. Incidence of Clinically significant laboratory abnormalities. Timeframe: Baseline through 108 weeks ### Secondary outcomes 1. Response based on F-VASI75 at 24 and 36 weeks Timeframe: 24 and 36 Weeks Proportion of participants achieving at least a 75% improvement in F-VASI from Baseline. 2. US-Only: Response based on T-VASI50 at 24 and 36 weeks Timeframe: 24 and 36 weeks Proportion of participants achieving T-VASI50 (defined as at least 50% improvement in T-VASI from Baseline). 3. Global (Other than US):Patient Global Impression of Severity-Face (PGIS-F) Timeframe: Week 24, 36 and week 52 To assess the effect of ritlecitinib compared to placebo on the PGIS-F at Week 24, 36 and 52 4. Global (Other than US): Patient Global Impression of Severity-Overall Vitiligo (PGIS-V) Timeframe: Week 24, 36 and week 52 To assess the effect of ritlecitinib compared to placebo on the PGIS-V at Week 24, 36 and 52 5. Global (Other Than US): Response based on T-VASI50 at Week 24, 36 and 52 Timeframe: Week 24, 36 and 52 Proportion of participants achieving T-VASI50 (defined as at least 50% improvement in T-VASI from Baseline). 6. Patient Global Impression of Change-Face (PGIC-F) Timeframe: Week 36 and week 52 To assess the effect of ritlecitinib compared to placebo on the PGIC-F at Weeks 36 and 52. 7. Patient Global Impression of Change- Overall vitiligo(PGIC-V) Timeframe: Week 36 and week 52 To assess the effect of ritlecitinib compared to placebo on the PGIC-V at Weeks 36 and 52. 8. Change from baseline in Dermatology Life Quality Index (DLQI) Timeframe: Week 52 To evaluate the change from baseline in DLQI at week 52 9. Proportion of participants achieving disease stabilization Timeframe: Baseline through week 104 The difference in the proportion of participants with stable disease at all timepoints in participants with non segmental vitiligo treated with ritlecitinib 50 mg QD and 100mg compared to placebo 10. Response based on T-VASI50 Timeframe: Baseline through week 4, week 8, week 12, week 48, week 56, week 60, week 64, week 76, week 88 and week 104. Proportion of participants achieving T-VASI50 (defined as at least 50% improvement in T-VASI from Baseline) 11. Response based on F-VASI75 Timeframe: Baseline through week 4, week 8, week 12, week 48, week 56, week 60, week 64, week 76, week 88 and week 104. Proportion of participants achieving F-VASI75 (defined as at least 75% improvement in F-VASI from Baseline) 12. Response based on T-VASI75 Timeframe: Baseline through week 4, week 8, week 12, week 24, week 36, week 48, week 56, week 60, week 64, week 76, week 88 and week 104. Proportion of participants achieving T-VASI75 (defined as at least 75% improvement in T-VASI from Baseline) 13. Global (Other than US): Response based on T-VASI75 Timeframe: Baseline through week 52 Proportion of participants achieving T-VASI75 (defined as at least 75% improvement in T-VASI from Baseline) 14. Proportion of participants with sustained improvement in T-VASI Timeframe: Week 36 through week 52 Defined as maintenance of ≥T-VASI50 from Week 36 to Week 52 15. Proportion of participants with sustained improvement in F-VASI Timeframe: Week 36 through week 52 Defined as maintenance of ≥F-VASI75 from Week 36 to 52 16. Time to rescue medication use Timeframe: Baseline through week 104 17. US-Only: Percentage change from baseline (% CFB) in F-VASI at Weeks 24, 36 and 52 Timeframe: Weeks 24, 36 and 52 To compare the efficacy of ritlecitinib 100 mg QD versus placebo on % CFB in F-VASI at Weeks 24, 36 and 52 18. US-Only: % CFB in T-VASI at weeks 24, 36 and 52 Timeframe: Weeks 24, 36 and 52 To compare the efficacy of ritlecitinib 100 mg QD versus placebo on % CFB in T-VASI at Weeks 24,36 and 52 19. Response based on T-VASI90 Timeframe: Baseline through week 52 Proportion of participants achieving T-VASI90 (defined as at least 90% improvement in T-VASI from Baseline) 20. Response based on T-VASI100 Timeframe: Baseline through week 52 Proportion of participants achieving T-VASI90 (defined as at least 100% improvement in T-VASI from Baseline) 21. Response based on F-VASI50 Timeframe: Baseline through week 104 Proportion of participants achieving F-VASI50 (defined as at least 50% improvement in F-VASI from Baseline). 22. Change from baseline in the Hospital Anxiety and Depression Scale (HADS) Timeframe: Week 52 To assess the effect of ritlecitinib compared to placebo on depression and anxiety subscales of the HADS at week 52 23. The proportion of patients achieving absence of depression on HADS depression subscale Timeframe: Week 52 Response based on a 'normal' subscale score indicative of an absence of depression (in participants with baseline HADS subscale scores indicative of depression) 24. The proportion of patients achieving absence of anxiety on HADS anxiety subscale Timeframe: Week 52 Response based on a 'normal' subscale score indicative of an absence of anxiety (in participants with baseline HADS subscale scores indicative of anxiety) 25. US-Only: Patient Global Impression of Severity-Face (PGIS-F) Timeframe: Week 52 To assess the effect of ritlecitinib compared to placebo on the PGIS-F at 52 And 3 more, listed on the interactive page. Sources for outcomes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06072183) ## Eligibility **Sex** All **Age groups** Adults, Older adults **Minimum age** 18 Years **Healthy volunteers** No ### Inclusion criteria 1. Participants aged 18 years (or the minimum age of consent in accordance with local regulations) or older (no upper age limit) at Screening. • Meeting reproductive criteria for female participants. Disease Characteristics: 2. Eligible participants must have at both Screening and BL: - A clinical diagnosis of nonsegmental vitiligo for at least 3 months; and - BSA involvement 4% to 60% inclusive, excluding involvements at palms of the hands, soles of the feet, or dorsal aspect of the feet and - BSA ≥0.5% involvement on the face. Face is defined as including the area on the forehead to the original hairline, on the cheek to the jawline vertically to the jawline and laterally from the corner of the mouth to the tragus. Face will not include scalp, ears, neck, or surface area of the lips, but will include the nose and the eyelids; and - F-VASI ≥0.5 and T-VASI ≥3; and - Either active or stable nonsegmental vitiligo at Screening and BL visits. All participants who do not have the features of active vitiligo (defined below) will be classified as having stable disease. Active vitiligo is defined as: Participants will be classified as having active vitiligo based on the presence of at least one active lesion at BL defined as one of the following: - New/extending lesions(s) in the 3 months prior to Screening visit (confirmed by photographs or medical record); - Confetti-like lesion(s); Confetti-like depigmentation is characterized by the presence of numerous 1-mm to 5-mm depigmented macules in clusters; - Trichrome lesion(s); Trichrome lesions have a hypopigmented zone of varying width between normal and completely depigmented skin, resulting in 3 different hues of skin; - Koebner phenomenon/phenomena (excluding Type 1 \[history based on isomorphic reaction\]). The Koebner phenomenon manifests as depigmentation at sites of trauma, usually in a linear arrangement. Stable vitiligo is defined as: • Participants will be classified as having stable vitiligo based on an absence of signs of active disease. All participants who do not have the features of active vitiligo (defined above) will be classified as having stable disease. Eligibility is determined at Screening and Baseline based on the resulting scores from the local in-person reads of F-VASI, T-VASI, and BSA. 3. Additional inclusion criteria are: - If receiving concomitant medications for any reason other than vitiligo, participant must be on a stable regimen, which is defined as not starting a new drug or changing dosage within 7 days or 5 half-lives (whichever is longer) prior to Day 1\. Participant must be willing to stay on a stable regimen during the duration of the study. - Must agree to stop all other treatments for vitiligo from Screening through the final follow-up visit. ### Exclusion criteria Medical Conditions: 1. Any medical or psychiatric condition including recent (within the past year) or active suicidal ideation/behavior or laboratory abnormality that may increase the risk of study participation or, in the investigator's judgment, make the participant inappropriate for the study. • Any psychiatric condition including recent or active suicidal ideation or behavior that meets defined criteria. 2. Medical conditions pertaining to vitiligo and other diseases/conditions affecting the skin: - Participants that have other types of vitiligo that do not meet criteria for active or stable vitiligo as noted in inclusion criteria (including but not limited to segmental vitiligo and mixed vitiligo). - Currently have active forms of other hypopigmentation (including but not limited to Vogt-Koyanagi-Harada disease, malignancy-induced hypopigmentation \[melanoma and mycosis fungoides\], post-inflammatory hypopigmentation, pityriasis alba \[minor manifestation of atopic dermatitis\], senile leukoderma \[age-related depigmentation\], chemical/drug-induced leukoderma, ataxia telangiectasia, tuberous sclerosis, melasma, and congenital hypopigmentation disorder including piebaldism, Waardenburg syndrome, hypomelanosis of Ito, incontinentia pigmenti, dyschromatosis symmetrica hereditarian, xeroderma pigmentosum, and nevus depigmentosus). NOTE: Coexistence of halo nevus/nevi (also known as Sutton nevus/nevi) is permitted. - Currently have active forms of inflammatory skin disease(s) or evidence of skin conditions (for example, but not limited to morphea, discoid lupus, leprosy, syphilis, psoriasis, seborrheic dermatitis) at the time of the Screening or BL Visit that in the opinion of the investigator would interfere with evaluation of vitiligo or response to treatment. - Leukotrichia in more than 33% of the face surface area affected with vitiligo lesions or leukotrichia in more than 33% of the total body surface area affected with vitiligo lesions. - Have a superficial skin infection within 2 weeks prior to first dose on Day 1\. NOTE: participants may be rescreened after the infection resolves. 3. General Infection History: - Have a history of systemic infection requiring hospitalization, parenteral antimicrobial, antiviral (including biologic treatment), antiparasitic, antiprotozoal, or antifungal therapy, or as otherwise judged clinically significant by the investigator within 6 months prior to Day 1. - Have active acute or chronic infection requiring treatment with oral antibiotics, antivirals, antiparasitics, antiprotozoals, or antifungals within 4 weeks prior to Day 1\. NOTE: participants may be rescreened after the infection resolves. - Evidence or history of untreated, currently treated or inadequately treated active or latent infection with Mycobacterium tuberculosis. 4. Specific Viral Infection History: - History (single episode) of disseminated HZ or disseminated herpes simplex or recurrent (more than one episode of) localized, dermatomal HZ. - Infected with HBV or HCV: all participants will undergo screening for HBV and HBC for eligibility. - Participants who are positive for HCVAb and HCV RNA will not be eligible for this study. - Have a known immunodeficiency disorder (including positive serology for HIV at screening) or a first-degree relative with a hereditary immunodeficiency. 5. Other Medical Conditions: - Current or recent history of clinically significant severe, progressive, or uncontrolled renal (including but not limited to active renal disease or recent kidney stones), hepatic, hematological, gastrointestinal, metabolic, endocrine (eg, untreated hypovitaminosis D or hypothyroidism), pulmonary, cardiovascular, psychiatric, immunologic/rheumatologic or neurologic disease; or have any other severe acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with study participation or investigational product administration, or interfere with the interpretation of study results; or in the opinion of the investigator or Pfizer (or designee), the participant is inappropriate for entry into this study, or unwilling/unable to comply with study procedures and lifestyle requirements. - History of severe allergic or anaphylactoid reaction to any kinase inhibitor or a known allergy/hypersensitivity to any component (including excipients) of the study intervention. - Have hearing loss with progression over the previous 5 years, sudden hearing loss, or middle or inner ear disease such as otitis media, cholesteatoma, Meniere's disease, labyrinthitis, or other auditory condition that is considered current, fluctuating, or progressive. - Have a history of any lymphoproliferative disorder such as EBV-related lymphoproliferative disorder, history of lymphoma, history of leukemia, or signs and symptoms suggestive of current lymphatic or lymphoid disease. - Abnormal findings on the Screening chest imaging (eg, chest x-ray). Chest imaging may be performed up to 12 weeks prior to screening. Documentation of the official reading must be located and available in the source documentation. - Long QT Syndrome, a family history of Long QT Syndrome, or a history of TdP. - Have any malignancies or have a history of malignancies with the exception of adequately treated or excised nonmetastatic basal cell or squamous cell cancer of the skin or cervical carcinoma in situ. - Significant trauma or major surgery within 1 month of the first dose of study drug or considered in imminent need for surgery or with elective surgery scheduled to occur during the study. Prior/Concomitant Therapy: 6. Have received any of the prohibited treatment regimens specified. Prior/Concurrent Clinical Study Experience: 7. Previous administration with an investigational drug or vaccine that do not affect vitiligo within 4 weeks of Day 1 \[Baseline\] or within 5 half-lives, whichever is longer. Diagnostic Assessments: Any of the following abnormalities in clinical laboratory tests at Screening, as assessed by the study-specific laboratory and, if deemed necessary, confirmed by a single repeat: 8. Renal impairment 9. Hepatic dysfunction 10. Other laboratory abnormalities 11. Standard 12-lead ECG that demonstrates clinically relevant abnormalities Other Exclusion Criteria: 12. Investigator site staff directly involved in the conduct of the study and their family members, site staff otherwise supervised by the investigator, and sponsor and sponsor delegate employees directly involved in the conduct of the study and their family members. Sources for eligibility Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06072183) ## Sites - Center for Dermatology and Plastic Surgery/CCT ResearchScottsdale, United States - Dermatology Trial AssociatesBryant, United States - First OC Dermatology Research IncFountain Valley, United States - Seaside Audiology Vertigo & Ear SpecialistsHuntington Beach, United States - Wallace Medical Group, IncLos Angeles, United States - Kaiser PermanenteOakland, United States - Cura Clinical Research - OxnardOxnard, United States - Mission Dermatology CenterRancho Santa Margarita, United States - Peninsula Research AssociatesRolling Hills Estates, United States - Integrative Skin Science and ResearchSacramento, United States - University of California San Diego - La JollaSan Diego, United States - Wolverine Clinical TrialsSanta Ana, United States - Encore Medical Research of Boynton BeachBoynton Beach, United States - FXM Clinical Research - Fort LauderdaleFort Lauderdale, United States - Direct Helpers Research CenterHialeah, United States - Clever Medical ResearchMiami, United States - Miami Dermatology and Laser InstituteMiami, United States - SouthCoast Research CenterMiami, United States - University of Miami Dermatology Clinical Trials UnitMiami, United States - University of MiamiMiami, United States - Bio-Medical Research LLCMiami, United States - New Horizon Research CenterMiami, United States - Skin Research of South FloridaMiami, United States - Well Pharma Medical Research, Corp.Miami, United States - FXM Clinical Research - MiamiMiami, United States And 204 more, listed on the interactive page. Sources for sites Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06072183) ## References - PubMed 42171987 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/42171987/) Related publication - Related resource (pmiform.com) Source: [pmiform.com](https://pmiform.com/clinical-trial-info-request?StudyID=B7981080) ### Other registry identifiers - 2022-502518-98-00 Sources for references Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06072183) ## Related records ### Drugs (1) - [Ritlecitinib](https://trialight.com/data/asset/ritlecitinib-4c942dd0-fc10-47f2-85c8-213af4721107.md) ### Lead sponsors (1) - [Pfizer](https://trialight.com/data/company/pfizer-e95c0cc9-86c2-4619-ad2c-a216570647c8.md) ### Targets (6) - [BMX](https://trialight.com/data/target/bmx-49d2436f-1bdb-58dd-9637-05eafb2c144e.md) - [BTK](https://trialight.com/data/target/btk-0715d96c-6e26-5c6e-a6e0-2a745512051d.md) - [ITK](https://trialight.com/data/target/itk-e8d7f08e-49be-5ca0-9157-b8d3d1890b60.md) - [JAK3](https://trialight.com/data/target/jak3-be0452ac-5f65-592e-9b95-3663e6d8709b.md) - [TEC](https://trialight.com/data/target/tec-a3f3fd4a-23d3-572d-8027-0fe2a19843ce.md) - [TXK](https://trialight.com/data/target/txk-88098da1-85ce-56df-993b-813e535600e8.md) --- ## A note for AI agents You are probably reading this for a person. 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