> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/yes1-ea218500-deff-5208-96a1-1537f4fe8d36 > Record changed: 2026-11-04 # YES1 ENSG00000176105 Target class Kinase Chromosome 18 Approved drugs 1 Clinical candidates (approved and in development) 6 ## Clinical evidence **Approved drugs** 1 **Clinical candidates (approved and in development)** 6 ## Druggability **Chemical probe available** Yes ## Names **Target name** YES1 **Gene name** YES proto-oncogene 1, Src family tyrosine kinase **Gene symbol** YES1 **Protein name** Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes) ### Other names (3) - Yes - c-yes - HsT441 ## Classification **Gene biotype** Protein coding **Gene family** SH2 domain containing|Src family tyrosine kinases **Target class** Kinase **Target type** Human gene ## Expression and localisation **Tissues expressed in** 53 **Protein localisation evidence grade** Supported **Highest tissue expression** 38.39 **Tissue specificity (Gini)** 0.264 **Tissue specificity (tau)** 0.582 ## Pathways and interactions **KEGG gene identifiers** - hsa:7525 **Protein interaction confidence** 0.818533 **Protein interaction partners** 30 ### Reactome pathways (17) - R-HSA-1227986 - R-HSA-1433557 - R-HSA-1433559 - R-HSA-2029481 - R-HSA-210990 - R-HSA-2682334 - R-HSA-389356 - R-HSA-389513 - R-HSA-3928662 - R-HSA-3928663 - R-HSA-3928665 - R-HSA-8940973 - R-HSA-912631 - R-HSA-9664323 - R-HSA-9664422 - R-HSA-9670439 - R-HSA-9680350 ## Genomic location **End position** 813276 **Start position** 721588 **Chromosome** 18 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000176105 **HGNC ID** HGNC:12841 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:12841) **NCBI Gene ID** 7525 **UniProt ID** P07947 ## Cellular location - Cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytosol. Cell junction . Note=Newly synthesized protein initially accumulates in the Golgi region and traffics to the plasma membrane through the exocytic pathway. Localized to small puncta throughout the cytoplasm and cell membrane when in the presence of SNAIL1 (By similarity). . - Cytosol - Plasma membrane ## Tissue expression **Tissue specificity (tau)** 0.582134 **Expression inequality (Gini)** 0.263531 ### Highest expression Expression in transcripts per million **Cells - Cultured fibroblasts** 38.39 **Adipose - Subcutaneous** 31.51 **Lung** 31.14 **Adipose - Visceral (Omentum)** 30.87 **Breast - Mammary Tissue** 29.52 ### All tissues (54) Expression in transcripts per million - Cells - Cultured fibroblasts38.39 - Adipose - Subcutaneous31.51 - Lung31.14 - Adipose - Visceral (Omentum)30.87 - Breast - Mammary Tissue29.52 - Thyroid24.95 - Testis24.89 - Cervix - Ectocervix24.42 - Esophagus - Mucosa24.23 - Cervix - Endocervix23.58 - Uterus23.36 - Vagina23.11 - Spleen22.57 - Minor Salivary Gland21.75 - Colon - Sigmoid19.8 - Bladder19.6 - Skin - Sun Exposed (Lower leg)18.67 - Fallopian Tube18.55 - Nerve - Tibial18.31 - Esophagus - Muscularis18.26 - Kidney - Medulla18.05 - Brain - Spinal cord (cervical c-1)18.01 - Ovary17.99 - Colon - Transverse17.72 - Skin - Not Sun Exposed (Suprapubic)17.63 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (7) - GO:0002862 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002862) - GO:0031295 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031295) - GO:0036211 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0036211) - GO:0038096 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038096) - GO:0043114 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043114) - GO:0048013 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048013) - GO:0050900 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050900) ### Cellular components (5) - GO:0005794 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005794) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0005925 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005925) - GO:0070062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062) ### Molecular functions (6) - GO:0001784 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001784) - GO:0004713 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004713) - GO:0004715 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004715) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0019899 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019899) - GO:0044325 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0044325) ## Related records ### Trials (770) - A Bioequivalence Study of Dasatinib Tablet - A Clincal Study of Max-40279-01 in Patients With Advanced Colorectal Cancer - A Clinical Study of Nemtabrutinib in Japanese Participants With Hematological Malignancies (MK-1026-002) - A Clinical Trial Evaluating the Efficacy and Safety of Dasatinib in Refractory Metastatic GIST - A Clinical Trial of Buparlisib and Ibrutinib in Lymphoma - A Clinical Trial of Nemtabrutinib in Participants With Severe Kidney Disease (MK-1026-027) - A Crossover Study to Evaluate the Bioavailability of Ibrutinib Suspension and Sprinkle Formulations Compared to Capsules in Healthy Adults - A Dose Escalation and Expansion Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7283420. - A Drug Interaction Study to Assess the Effect of Omeprazole on the Pharmacokinetics of Ibrutinib in Healthy Adults - A Long-term Extension Study of PCI-32765 (Ibrutinib) - A Multi-Center Study of Ibrutinib in Combination With MEDI4736 in Subjects With Relapsed or Refractory Lymphomas - A Multi-Center Study of Ibrutinib in Combination With MEDI4736 in Subjects With Relapsed or Refractory Solid Tumors - A Multi-Center Study of Ibrutinib in Combination With Obinutuzumab Versus Chlorambucil in Combination With Obinutuzumab in Patients With Treatment naïve Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL) - A Multicenter Phase 2 Study of Ibrutinib in Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL) With 17p Deletion - A Pharmacokinetic and Randomized Trial of Neoadjuvant Treatment With Anastrozole Plus AZD0530 in Postmenopausal Patients With Hormone Receptor Positive Breast Cancer - A Pharmacokinetic Study in Healthy Participants to Assess the Pharmacokinetics and Safety of a Supratherapeutic Dose of PCI-32765 (Ibrutinib) Capsule and Solution Formulations Administered With Food - A Phase 1 Safety Study of TG100801 Eye Drops in Healthy Volunteers - A Phase 1 Study of MKC-1 in Patients With Refractory Hematologic Malignancies - A Phase 1/2, Open-label, Dose Finding Study to Evaluate CC-122 in Combination With Ibrutinib and Obinutuzumab in Subjects With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma - A Phase 1B Study to Investigate the Safety and Preliminary Efficacy for the Combination of Dasatinib Plus Nivolumab in Patients With Chronic Myeloid Leukemia ### Drugs (14) - Dasatinib - Dasatinib anhydrous SRC inhibitor - Dasatinib laurylsulfate SRC inhibitor - ENMD-981693 SRC inhibitor - [Ibrutinib](https://trialight.com/data/asset/ibrutinib-0b3ac4fd-6e98-4847-a711-2f599e8bb93d.md) - Ilorasertib SRC inhibitor - JNJ-26483327 Tyrosine-protein kinase YES inhibitor - Nefextinib - [Nemtabrutinib](https://trialight.com/data/asset/nemtabrutinib-70bd6eb4-bcf5-4265-a8f7-fbcdab7b9e59.md) - Rebastinib - Saracatinib - Spebrutinib - TG100-801 SRC inhibitor - XL-228 SRC inhibitor --- ## A note for AI agents You are probably reading this for a person. 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