> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/wrn-5a421d7b-acf6-57db-9721-196cb81b0e16
> Record changed: 2026-11-04

# WRN

ENSG00000165392

Target class

Enzyme

Chromosome

8

## Clinical evidence

**ClinGen gene-disease validity**

Definitive

## Druggability

**Chemical probe available**

Yes

## Names

**Target name**

WRN

**Gene name**

WRN RecQ like helicase

**Gene symbol**

WRN

**Protein name**

Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (DNA helicase, RecQ-like type 3) (RecQ protein-like 2) (Werner syndrome protein) \[Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 5.6.2.4) (DNA 3'-5' helicase WRN)\]

### Other names (2)

- RECQL2
- RECQ3

## Classification

**Gene biotype**

Protein coding

**Gene family**

Exonucleases|RecQ like helicases

**Target class**

Enzyme

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

53

**Protein localisation evidence grade**

Enhanced

**Highest tissue expression**

19.37

**Tissue specificity (Gini)**

0.358

**Tissue specificity (tau)**

0.681

## Pathways and interactions

**KEGG gene identifiers**

- hsa:7486

**Protein interaction confidence**

0.848144

**Protein interaction partners**

125

### Reactome pathways (17)

- R-HSA-174414
- R-HSA-174437
- R-HSA-3108214
- R-HSA-5685938
- R-HSA-5685942
- R-HSA-5693554
- R-HSA-5693568
- R-HSA-5693579
- R-HSA-5693607
- R-HSA-5693616
- R-HSA-6804756
- R-HSA-69473
- R-HSA-9701192
- R-HSA-9704331
- R-HSA-9704646
- R-HSA-9709570
- R-HSA-9709603

## Genomic location

**End position**

31176138

**Start position**

31033779

**Chromosome**

8

**Strand**

Forward

## Identifiers

**Ensembl gene ID**

ENSG00000165392

**HGNC ID**

HGNC:12791

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:12791)

**NCBI Gene ID**

7486

**UniProt ID**

Q14191

## Cellular location

- Nucleus, nucleolus . Nucleus . Nucleus, nucleoplasm . Chromosome . Note=Gamma-irradiation leads to its translocation from nucleoli to nucleoplasm and PML regulates the irradiation-induced WRN relocation (PubMed:21639834). Localizes to DNA damage sites (PubMed:27063109). .
- Nuclear speckles

### Publication evidence (6)

- PubMed 23180761  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23180761/)
- PubMed 9618508  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/9618508/)
- PubMed 17563354  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/17563354/)
- PubMed 19652551  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/19652551/)
- PubMed 21639834  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/21639834/)
- PubMed 27063109  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/27063109/)

## Tissue expression

**Tissue specificity (tau)**

0.681495

**Expression inequality (Gini)**

0.358429

### Highest expression

Expression in transcripts per million

**Cells - EBV-transformed lymphocytes**

19.37

**Cells - Cultured fibroblasts**

17.03

**Uterus**

15.8

**Ovary**

11.83

**Nerve - Tibial**

11.72

### All tissues (54)

Expression in transcripts per million

- Cells - EBV-transformed lymphocytes19.37
- Cells - Cultured fibroblasts17.03
- Uterus15.8
- Ovary11.83
- Nerve - Tibial11.72
- Cervix - Endocervix11.4
- Testis10.49
- Fallopian Tube10.29
- Pituitary9.65
- Adipose - Subcutaneous9.47
- Artery - Tibial9.39
- Skin - Sun Exposed (Lower leg)9.37
- Breast - Mammary Tissue9.35
- Skin - Not Sun Exposed (Suprapubic)9.32
- Cervix - Ectocervix9.26
- Vagina8.64
- Bladder8.38
- Artery - Aorta8.33
- Artery - Coronary8.25
- Minor Salivary Gland7.86
- Thyroid7.34
- Adipose - Visceral (Omentum)7.33
- Lung7.23
- Esophagus - Gastroesophageal Junction7.02
- Prostate6.9

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (19)

- GO:0000723  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000723)
- GO:0000731  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000731)
- GO:0006259  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006259)
- GO:0006260  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006260)
- GO:0006284  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006284)
- GO:0006298  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006298)
- GO:0006302  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006302)
- GO:0006974  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006974)
- GO:0009267  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009267)
- GO:0010225  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010225)
- GO:0031297  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031297)
- GO:0032201  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032201)
- GO:0032392  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032392)
- GO:0061820  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0061820)
- GO:0071480  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071480)
- GO:0090398  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0090398)
- GO:0090656  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0090656)
- GO:0098530  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0098530)
- GO:1902570  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1902570)

### Cellular components (7)

- GO:0000781  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000781)
- GO:0005634  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634)
- GO:0005654  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005654)
- GO:0005694  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005694)
- GO:0005730  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005730)
- GO:0005813  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005813)
- GO:0016607  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016607)

### Molecular functions (22)

- GO:0000287  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000287)
- GO:0000400  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000400)
- GO:0000403  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000403)
- GO:0000405  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000405)
- GO:0003677  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003677)
- GO:0003678  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003678)
- GO:0004527  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004527)
- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)
- GO:0008408  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008408)
- GO:0009378  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009378)
- GO:0016887  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016887)
- GO:0030145  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030145)
- GO:0032405  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032405)
- GO:0042803  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042803)
- GO:0043138  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043138)
- GO:0044877  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0044877)
- GO:0051880  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051880)
- GO:0061749  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0061749)
- GO:0061821  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0061821)
- GO:0061849  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0061849)
- GO:0070337  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070337)
- GO:1905773  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1905773)

## Related records

### Trials (1)

- [Study of HRO761 Alone or in Combination in Cancer Patients With Specific DNA Alterations Called Microsatellite Instability or Mismatch Repair Deficiency.](https://trialight.com/data/trial/study-of-hro761-alone-or-in-combination-in-cancer-patients-42dcaedd-273a-457a-85ba-476b74f12afb.md)

### Drugs (1)

- [HRO-761](https://trialight.com/data/asset/hro-761-dab0f0f4-3147-4cf2-ba06-ca88d10ffe7f.md)

---

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