WRN

ENSG00000165392
Target class
Enzyme
Chromosome
8

ClinGen gene-disease validity
Definitive

Chemical probe available
Yes

Target name
WRN
Gene name
WRN RecQ like helicase
Gene symbol
WRN
Protein name
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (DNA helicase, RecQ-like type 3) (RecQ protein-like 2) (Werner syndrome protein) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 5.6.2.4) (DNA 3'-5' helicase WRN)]

  • RECQL2
  • RECQ3

Gene biotype
Protein coding
Gene family
Exonucleases|RecQ like helicases
Target class
Enzyme
Target type
Human gene

Tissues expressed in
53
Protein localisation evidence grade
Enhanced
Highest tissue expression
19.37
Tissue specificity (Gini)
0.358
Tissue specificity (tau)
0.681

KEGG gene identifiers
  • hsa:7486
Protein interaction confidence
0.848144
Protein interaction partners
125

  • R-HSA-174414
  • R-HSA-174437
  • R-HSA-3108214
  • R-HSA-5685938
  • R-HSA-5685942
  • R-HSA-5693554
  • R-HSA-5693568
  • R-HSA-5693579
  • R-HSA-5693607
  • R-HSA-5693616
  • R-HSA-6804756
  • R-HSA-69473
  • R-HSA-9701192
  • R-HSA-9704331
  • R-HSA-9704646
  • R-HSA-9709570
  • R-HSA-9709603

End position
31176138
Start position
31033779
Chromosome
8
Strand
Forward

Ensembl gene ID
ENSG00000165392
HGNC ID
HGNC:12791
www.genenames.org
NCBI Gene ID
7486
UniProt ID
Q14191

  • Nucleus, nucleolus . Nucleus . Nucleus, nucleoplasm . Chromosome . Note=Gamma-irradiation leads to its translocation from nucleoli to nucleoplasm and PML regulates the irradiation-induced WRN relocation (PubMed:21639834). Localizes to DNA damage sites (PubMed:27063109). .
  • Nuclear speckles

Tissue specificity (tau)
0.681495
Expression inequality (Gini)
0.358429

Expression in transcripts per million

Cells - EBV-transformed lymphocytes
19.37
Cells - Cultured fibroblasts
17.03
Uterus
15.8
Ovary
11.83
Nerve - Tibial
11.72

Expression in transcripts per million

  • Cells - EBV-transformed lymphocytes19.37
  • Cells - Cultured fibroblasts17.03
  • Uterus15.8
  • Ovary11.83
  • Nerve - Tibial11.72
  • Cervix - Endocervix11.4
  • Testis10.49
  • Fallopian Tube10.29
  • Pituitary9.65
  • Adipose - Subcutaneous9.47
  • Artery - Tibial9.39
  • Skin - Sun Exposed (Lower leg)9.37
  • Breast - Mammary Tissue9.35
  • Skin - Not Sun Exposed (Suprapubic)9.32
  • Cervix - Ectocervix9.26
  • Vagina8.64
  • Bladder8.38
  • Artery - Aorta8.33
  • Artery - Coronary8.25
  • Minor Salivary Gland7.86
  • Thyroid7.34
  • Adipose - Visceral (Omentum)7.33
  • Lung7.23
  • Esophagus - Gastroesophageal Junction7.02
  • Prostate6.9

And 29 more, listed on the interactive page.

Related records

Trials (1)

Drugs (1)