> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/wee1-8c0285e9-fac0-5703-a814-cf22335badee > Record changed: 2026-10-13 # WEE1 ENSG00000166483 Target class Kinase Chromosome 11 Approved drugs 0 Clinical candidates (approved and in development) 2 ## Clinical evidence **Approved drugs** 0 **Clinical candidates (approved and in development)** 2 ## Druggability **Chemical probe available** Yes ## Names **Other names** - WEE1A **Target name** WEE1 **Gene name** WEE1 G2 checkpoint kinase **Gene symbol** WEE1 **Protein name** Wee1-like protein kinase (WEE1hu) (EC 2.7.10.2) (Wee1A kinase) ## Classification **Gene biotype** Protein coding **Target class** Kinase **Target type** Human gene ## Expression and localisation **Tissues expressed in** 45 **Protein localisation evidence grade** Supported **Highest tissue expression** 53.99 **Tissue specificity (Gini)** 0.465 **Tissue specificity (tau)** 0.776 ## Pathways and interactions **KEGG gene identifiers** - hsa:7465 **Protein interaction confidence** 0.829564 **Protein interaction partners** 39 ### Reactome pathways (7) - R-HSA-156711 - R-HSA-69202 - R-HSA-69273 - R-HSA-69478 - R-HSA-69656 - R-HSA-75035 - R-HSA-983231 ## Genomic location **End position** 9593457 **Start position** 9573668 **Chromosome** 11 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000166483 **HGNC ID** HGNC:12761 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:12761) **NCBI Gene ID** 7465 **UniProt ID** P30291 ## Cellular location - Nucleus . - Nucleoli ### Publication evidence - PubMed 8348613 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/8348613/) ## Tissue expression **Tissue specificity (tau)** 0.775685 **Expression inequality (Gini)** 0.464802 ### Highest expression Expression in transcripts per million **Skin - Not Sun Exposed (Suprapubic)** 53.99 **Skin - Sun Exposed (Lower leg)** 37.18 **Uterus** 36.06 **Fallopian Tube** 29.21 **Cells - EBV-transformed lymphocytes** 28.52 ### All tissues (54) Expression in transcripts per million - Skin - Not Sun Exposed (Suprapubic)53.99 - Skin - Sun Exposed (Lower leg)37.18 - Uterus36.06 - Fallopian Tube29.21 - Cells - EBV-transformed lymphocytes28.52 - Bladder26.33 - Testis25.06 - Cells - Cultured fibroblasts24.7 - Artery - Aorta24.52 - Artery - Coronary21.41 - Colon - Sigmoid21.02 - Artery - Tibial20.88 - Esophagus - Gastroesophageal Junction18.65 - Esophagus - Mucosa18.6 - Esophagus - Muscularis17.99 - Breast - Mammary Tissue17.41 - Heart - Atrial Appendage17.2 - Minor Salivary Gland16.72 - Cervix - Ectocervix16.54 - Vagina15.48 - Thyroid15.03 - Ovary14.57 - Cervix - Endocervix13.86 - Small Intestine - Terminal Ileum13.49 - Colon - Transverse13.37 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (4) - GO:0000086 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000086) - GO:0010972 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010972) - GO:0045740 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045740) - GO:2000134 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:2000134) ### Cellular components (3) - GO:0005634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) - GO:0005654 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005654) - GO:0005730 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005730) ### Molecular functions (2) - GO:0004713 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004713) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## Related records ### Trials (74) - A Dose Escalation Study of Adavosertib (MK-1775) in Combination With Either Gemcitabine, Cisplatin, or Carboplatin in Adults With Advanced Solid Tumors (MK-1775-001) - A Dose Escalation Study of Adavosertib(MK1775) in Combination With 5-FU or 5-FU/CDDP in Patients With Advanced Solid Tumor (1775-005 - A Phase 0 Study of AZD1775 in Recurrent GBM Patients - A Phase 1b Study of ZN-c3 in Chinese Subjects - A Phase II, Study to Determine the Preliminary Efficacy of Novel Combinations of Treatment in Patients With Platinum Refractory Extensive-Stage Small-Cell Lung Cancer - A Placebo Controlled Study Comparing AZD1775+ Docetaxel Versus Placebo+Docetaxel to Treat Lung Cancer - A Study of Adavosertib (MK-1775) in Combination With Paclitaxel and Carboplatin Versus Paclitaxel and Carboplatin Alone for Participants With Platinum-Sensitive Ovarian Tumors With the P53 Gene Mutation (MK-1775-004) - A Study of Adavosertib (MK-1775) in Combination With Topotecan/Cisplatin in Participants With Cervical Cancer (MK-1775-008) - A Study of Adavosertib as Treatment for Uterine Serous Carcinoma - A Study of Azenosertib (ZN-c3) and Niraparib in Subjects With Platinum-Resistant Ovarian Cancer - A Study of Azenosertib (ZN-c3) in Combination With Gemcitabine in Subjects With Osteosarcoma - A Study of Azenosertib (ZN-c3) in Participants With Solid Tumors - A Study of Azenosertib (ZN-c3) in Patients With Ovarian Cancer - [A Study of Azenosertib (ZN-c3) in Subjects With Platinum-Resistant High-Grade Serous Ovarian, Fallopian Tube or Primary Peritoneal Cancer](https://trialight.com/data/trial/a-study-of-azenosertib-zn-c3-in-subjects-with-platinum-35a0b920-5423-4580-8bb9-86ecfa32b8d4.md) - A Study of Azenosertib (ZN-c3) in Women With Recurrent or Persistent Uterine Serous Carcinoma - A Study of Azenosertib (ZN-c3) Versus Investigator's Choice Chemotherapy in Subjects With Platinum-Resistant High-Grade Serous Ovarian, Primary Peritoneal, or Fallopian Tube Cancers Positive for Cyclin E1 Protein Expression - A Study to Assess the Effects of Itraconazole, Rifampicin, and Omeprazole on Pharmacokinetics of Adavosertib - A Study to Assess the Safety and Tolerability of Adavosertib for Patients With Advanced Solid Tumours - Adavosertib and Gemcitabine in Advanced Pancreatic - Adavosertib and Irinotecan Hydrochloride in Treating Younger Patients With Relapsed or Refractory Solid Tumors ### Drugs (2) - Adavosertib Serine/threonine-protein kinase WEE1 inhibitor - [Azenosertib](https://trialight.com/data/asset/azenosertib-944931bf-2ff3-48e7-8c82-2d2dde814b6e.md) Serine/threonine-protein kinase WEE1 inhibitor --- ## A note for AI agents You are probably reading this for a person. 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