> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/vkorc1-cc3ba0d2-543f-5d23-8210-88a7efbf0a89 > Record changed: 2026-10-13 # VKORC1 ENSG00000167397 Target class Enzyme Chromosome 16 Approved drugs 5 Clinical candidates (approved and in development) 7 ## Clinical evidence **Approved drugs** 5 **ClinGen gene-disease validity** Moderate **Clinical candidates (approved and in development)** 7 ## Druggability **Chemical probe available** No ## Names **Target name** VKORC1 **Gene name** Vitamin K epoxide reductase complex subunit 1 **Gene symbol** VKORC1 **Previous gene symbols** - VKCFD2 **Protein name** Vitamin K epoxide reductase complex subunit 1 (EC 1.17.4.4) (Vitamin K1 2,3-epoxide reductase subunit 1) ## Classification **Gene biotype** Protein coding **Gene family** Vitamin K epoxide reductase complex subunit 1 family **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Protein localisation evidence grade** Supported **Highest tissue expression** 306.7 **Tissue specificity (Gini)** 0.338 **Tissue specificity (tau)** 0.669 ## Pathways and interactions **KEGG gene identifiers** - hsa:79001 **Reactome pathways** - R-HSA-6806664 **Protein interaction confidence** 0.848684 **Protein interaction partners** 19 ## Genomic location **End position** 31095980 **Start position** 31090842 **Chromosome** 16 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000167397 **HGNC ID** HGNC:23663 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:23663) **NCBI Gene ID** 79001 **UniProt ID** Q9BQB6 ## Cellular location - Endoplasmic reticulum membrane - Multi-pass membrane protein . - Endoplasmic reticulum ### Publication evidence (7) - PubMed 14765194 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/14765194/) - PubMed 15716279 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/15716279/) - PubMed 16270630 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/16270630/) - PubMed 20978134 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/20978134/) - PubMed 22923610 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/22923610/) - PubMed 20696932 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/20696932/) - PubMed 33154105 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/33154105/) ## Tissue expression **Tissue specificity (tau)** 0.669298 **Expression inequality (Gini)** 0.338218 ### Highest expression Expression in transcripts per million **Cells - Cultured fibroblasts** 306.7 **Artery - Aorta** 269.24 **Liver** 244.21 **Artery - Coronary** 211.48 **Cervix - Ectocervix** 190.45 ### All tissues (54) Expression in transcripts per million - Cells - Cultured fibroblasts306.7 - Artery - Aorta269.24 - Liver244.21 - Artery - Coronary211.48 - Cervix - Ectocervix190.45 - Uterus186.88 - Artery - Tibial182.94 - Cervix - Endocervix182.58 - Ovary178.47 - Pituitary171.05 - Nerve - Tibial162.95 - Fallopian Tube148.86 - Bladder136.87 - Esophagus - Gastroesophageal Junction133.5 - Vagina128.97 - Colon - Sigmoid127.86 - Thyroid127.63 - Adipose - Subcutaneous123.59 - Adipose - Visceral (Omentum)117.93 - Lung117.59 - Esophagus - Muscularis116.99 - Breast - Mammary Tissue116.4 - Adrenal Gland112.42 - Prostate110.68 - Minor Salivary Gland105.57 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (4) - GO:0006805 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006805) - GO:0007596 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007596) - GO:0017187 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0017187) - GO:0042373 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042373) ### Cellular components (2) - GO:0005783 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005783) - GO:0005789 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005789) ### Molecular functions (3) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0047057 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0047057) - GO:0047058 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0047058) ## Related records ### Trials (552) - "ORBIT" Versus "HAS-BLED" Scores in Predicting Major Bleeding in Patients With Atrial Fibrillation Receiving Oral Anticoagulants. - 3 Months' Versus 6 Months' Anticoagulation in Patients With DVT and/or PE - A Bioequivalence Study of Advil Tablet (Mini) (Ibuprofen 200 mg) Versus Advil Tablet (Ibuprofen 200 mg) in Healthy Adult Subjects Under Fasted Conditions and Bioavailability Assessment of Advil Tablet (Mini) Under Fed Conditions - A Clinical Study to Determine the Effect of YM178 on the Pharmacokinetics of Warfarin in Healthy Subjects - A Clinical Trial Comparing Efficacy and Safety of Dabigatran Etexilate With Warfarin in Patients With Cerebral Venous and Dural Sinus Thrombosis (RE-SPECT CVT) - A Clinical Trial to Evaluate the Effect of Fimarsartan on Pharmacodynamics, Pharmacokinetics, and the Safety of Warfarin in Healthy Male Volunteers - A Comparative Study of the Treatment of Real-world Patients With Clear Cell Carcinoma of the Ovary - A Dose Response Study of Dabigatran Etexilate(BIBR 1048) in Pharmacodynamics and Safety in Patients With Non-valvular Atrial Fibrillation in Comparison to Warfarin - A Drug Drug Interaciton Study of Imrecoxib and Warfarin in Healthy Volunteers - A Drug Interaction Study of Danicopan - A Drug Interaction Study of Lanabecestat (LY3314814) and Warfarin in Healthy Participants - A Drug Interaction Study of LY3871801 in Healthy Participants - A Drug Interaction Study of Warfarin and Canagliflozin in Healthy Adult Volunteers - A Drug Interaction Study to Assess the Effect of LY317615 on the Metabolic Pathway of Warfarin - A Drug Interaction Study With Albiglutide and Warfarin - A Drug-Drug Interaction (DDI) Study of LY3437943 in Obese Participants - A Drug-Drug Interaction Study Between AZD9668 and Warfarin to Study the Effect of AZD9668 on the Metabolism and Effect of Warfarin - A Drug-Drug Interaction Study Between XW003 and Metformin, Warfarin, Rosuvastatin or Digoxin - A Drug-Drug Interaction Study of HDM1002 and Metformin, Empagliflozin, Midazolam, Valsartan, and Warfarin - A Drug-Drug Interaction Study of Warfarin and PA21 ### Drugs (8) - Acenocoumarol Vitamin k epoxide reductase complex subunit 1 isoform 1 inhibitor - Dicumarol Vitamin k epoxide reductase complex subunit 1 isoform 1 inhibitor - Phenindione Vitamin k epoxide reductase complex subunit 1 isoform 1 inhibitor - Phenprocoumon Vitamin k epoxide reductase complex subunit 1 isoform 1 inhibitor - Tecarfarin Vitamin k epoxide reductase complex subunit 1 isoform 1 inhibitor - [Warfarin](https://trialight.com/data/asset/warfarin-e500f94c-c2a3-4434-8e09-97345b672b83.md) Vitamin k epoxide reductase complex subunit 1 isoform 1 inhibitor - Warfarin potassium Vitamin k epoxide reductase complex subunit 1 isoform 1 inhibitor - Warfarin sodium Vitamin k epoxide reductase complex subunit 1 isoform 1 inhibitor --- ## A note for AI agents You are probably reading this for a person. 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