> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/vegfa-d5a98392-6ee9-5b71-b7a2-9a73ce1575d2
> Record changed: 2026-10-13

# VEGFA

ENSG00000112715

Target class

Secreted protein

Chromosome

6

Approved drugs

7

Clinical candidates (approved and in development)

12

## Clinical evidence

**Approved drugs**

7

**ClinGen gene-disease validity**

Limited

**Clinical candidates (approved and in development)**

12

## Druggability

**Chemical probe available**

No

## Names

**Target name**

VEGFA

**Gene name**

Vascular endothelial growth factor A

**Gene symbol**

VEGFA

**Previous gene symbols**

- VEGF

**Protein name**

Vascular endothelial growth factor A, long form (L-VEGF) (Vascular permeability factor) (VPF) \[Cleaved into: N-VEGF; VEGFA\]

### Other names (2)

- VEGF-A
- VPF

## Classification

**Gene biotype**

Protein coding

**Gene family**

VEGF family

**Target class**

Secreted protein

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

54

**Highest tissue expression**

615.37

**Tissue specificity (Gini)**

0.457

**Tissue specificity (tau)**

0.883

## Pathways and interactions

**KEGG gene identifiers**

- hsa:7422

### Reactome pathways (7)

- R-HSA-114608
- R-HSA-1234158
- R-HSA-194138
- R-HSA-194313
- R-HSA-195399
- R-HSA-6785807
- R-HSA-8866910

## Genomic location

**End position**

43786487

**Start position**

43770184

**Chromosome**

6

**Strand**

Forward

## Identifiers

**Ensembl gene ID**

ENSG00000112715

**HGNC ID**

HGNC:12680

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:12680)

**NCBI Gene ID**

7422

**UniProt ID**

P15692

## Cellular location

- \[N-VEGF\]: Cytoplasm . Nucleus . Note=Cytoplasmic in normoxic conditions and localizes to the nucleus under hypoxic conditions. .
- SUBCELLULAR LOCATION: \[VEGFA\]: Secreted .
- SUBCELLULAR LOCATION: \[Isoform L-VEGF189\]: Endoplasmic reticulum . Golgi apparatus . Secreted, extracellular space, extracellular matrix .
- SUBCELLULAR LOCATION: \[Isoform VEGF121\]: Secreted .
- SUBCELLULAR LOCATION: \[Isoform VEGF165\]: Secreted .
- SUBCELLULAR LOCATION: \[Isoform VEGF189\]: Secreted. Note=Cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin.

### Publication evidence (4)

- PubMed 15896327  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/15896327/)
- PubMed 35455969  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/35455969/)
- PubMed 11563986  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/11563986/)
- PubMed 11731620  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/11731620/)

## Tissue expression

**Tissue specificity (tau)**

0.882866

**Expression inequality (Gini)**

0.457177

### Highest expression

Expression in transcripts per million

**Thyroid**

615.37

**Uterus**

258.8

**Adipose - Visceral (Omentum)**

200.88

**Prostate**

182.11

**Lung**

158.59

### All tissues (54)

Expression in transcripts per million

- Thyroid615.37
- Uterus258.8
- Adipose - Visceral (Omentum)200.88
- Prostate182.11
- Lung158.59
- Liver143.58
- Spleen139.72
- Muscle - Skeletal128.95
- Heart - Atrial Appendage127.23
- Breast - Mammary Tissue119.8
- Kidney - Cortex118.08
- Vagina115.05
- Cells - Cultured fibroblasts111.26
- Kidney - Medulla110.4
- Adipose - Subcutaneous108.66
- Fallopian Tube103.28
- Bladder96.02
- Cervix - Endocervix94.15
- Cervix - Ectocervix90.29
- Esophagus - Mucosa85.27
- Nerve - Tibial78.22
- Cells - EBV-transformed lymphocytes74.45
- Stomach70.72
- Heart - Left Ventricle66.89
- Small Intestine - Terminal Ileum64.23

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (53)

- GO:0000122  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000122)
- GO:0001525  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001525)
- GO:0001569  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001569)
- GO:0001570  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001570)
- GO:0001666  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001666)
- GO:0001934  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001934)
- GO:0001938  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001938)
- GO:0002042  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002042)
- GO:0002092  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002092)
- GO:0002687  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002687)
- GO:0007200  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007200)
- GO:0007399  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007399)
- GO:0008284  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008284)
- GO:0008360  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008360)
- GO:0010595  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010595)
- GO:0010629  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010629)
- GO:0030224  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030224)
- GO:0030225  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030225)
- GO:0030335  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030335)
- GO:0031334  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031334)
- GO:0035148  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035148)
- GO:0035767  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035767)
- GO:0035924  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035924)
- GO:0036324  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0036324)
- GO:0038033  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038033)

And 28 more, listed on the interactive page.

### Cellular components (9)

- GO:0005576  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576)
- GO:0005634  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634)
- GO:0005737  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737)
- GO:0005783  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005783)
- GO:0005794  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005794)
- GO:0005912  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005912)
- GO:0009986  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009986)
- GO:0030141  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030141)
- GO:0031093  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031093)

### Molecular functions (14)

- GO:0001968  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001968)
- GO:0005125  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005125)
- GO:0005161  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005161)
- GO:0005172  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005172)
- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)
- GO:0008083  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008083)
- GO:0008201  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008201)
- GO:0030297  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030297)
- GO:0042056  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042056)
- GO:0042802  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042802)
- GO:0043183  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043183)
- GO:0043184  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043184)
- GO:0048018  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048018)
- GO:0050840  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050840)

## On-target safety

- Increase, Early Life Stage Mortality  
### Effects

  - Inhibition/Decrease/Downregulation  
### Studies

  - cell-based  
Evidence source  
Source: [aopwiki.org](https://aopwiki.org/aops/150)

## Related records

### Trials (3,851)

- - IKF/AIO-QUINTIS - Evaluating Fruquintinib in Combination With Tislelizumab in Microsatellite Stable / Proficient Mismatch Repair (MSS/pMMR) Metastatic Colorectal Cancer Without Active Liver Metastases
- "Phase II Study of PET Guided Neoadjuvant Chemotherapy (NAC) and Oncotype Guided Hormonal Therapy of Breast Cancer"
- "Stop Early Age-related Macular Degeneration (AMD) From Vision Loss Eternally" Study
- (PGA) for Platinum-resistant/Refractory, Paclitaxel-Pretreated Recurrent Ovarian and Peritoneal Carcinoma
- 131I-Omburtamab, in Recurrent Medulloblastoma and Ependymoma
- 1st Line Chemotherapy Alone or With Bevacizumab in Treating Older Patients With Metastatic Colorectal Cancer
- 1st Line Treatment of Bevacizumab-Taxane vs Bevacizumab-Exemestane in Metastatic Breast Cancer
- 1stline Study Capecitabine Administered on Continuous Way Plus Oxaliplatin&Bevacizumab Every 2weeks in Metastatic CCR.
- 2-arm Trial of Paclitaxel Plus Bevacizumab vs. Capecitabine Plus Bevacizumab
- 20089 TA+Lucentis Combo Intravitreal Injections for Treatment of Neovascular Age-related Macular Degeneration (AMD)
- 24 Week Study to Compare Systemic VEGF-levels of Ranibizumab and Aflibercept in DME.
- 25-G Vitrectomy With Ranibizumab or Triamcinolone Acetonide on PDR in China-Randomized Clinical Trial
- 25-Gauge Vitrectomy With Ranibizumab or Triamcinolone Acetonide on Proliferative Diabetic Retinopathy in China
- 2nd-line Treatment of Metastatic Colorectal Cancer
- 3 Month Outcome of Ziv-aflibercept for DME
- 4D-150 in Patients With Diabetic Macular Edema
- 4D-150 in Patients With Macular Neovascularization Secondary to Age-Related Macular Degeneration
- 4D-150 in Patients With Neovascular (Wet) Age-Related Macular Degeneration
- 5-Fluorouracil, Bevacizumab, and Radiation Followed by Modified FOLFOX6 and Bevacizumab in Stage II/III Rectal Cancer
- 5-Fluorouracil/Leucovorin (5FU/LV) in Combination With Regorafenib in Patients With Metastatic Colorectal Cancer

### Drugs (13)

- Abicipar pegol Vascular endothelial growth factor A inhibitor
- [Aflibercept](https://trialight.com/data/asset/aflibercept-6bb09e87-ca99-436b-8634-71b90510b8fb.md) Vascular endothelial growth factor A inhibitor
- [Bevacizumab](https://trialight.com/data/asset/bevacizumab-a9e09d09-2d3c-4fda-ad45-01fd000dd363.md) Vascular endothelial growth factor A inhibitor
- Bevacizumab gamma Vascular endothelial growth factor A binding agent
- Bevasiranib VEGF-A mRNA RNAi inhibitor
- Brolucizumab Vascular endothelial growth factor A inhibitor
- Conbercept Vascular endothelial growth factor A inhibitor
- [Faricimab](https://trialight.com/data/asset/faricimab-499c6bdf-255b-4e85-beb1-4b97ebbeaf6f.md) Vascular endothelial growth factor A inhibitor
- Muparfostat Vascular endothelial growth factor A inhibitor
- Pegaptanib octasodium Vascular endothelial growth factor A inhibitor
- Pegaptanib sodium Vascular endothelial growth factor A antagonist
- [Ranibizumab](https://trialight.com/data/asset/ranibizumab-2ca53f2a-3d69-417e-a84c-3f9e436c1913.md) Vascular endothelial growth factor A inhibitor
- Vanucizumab Vascular endothelial growth factor A inhibitor

---

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