> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/vdr-eaef72d7-61b6-52d0-b626-ff3aa6b0de1e > Record changed: 2026-10-13 # VDR ENSG00000111424 Target class Nuclear receptor Chromosome 12 Approved drugs 7 Clinical candidates (approved and in development) 18 ## Clinical evidence **Approved drugs** 7 **Clinical candidates (approved and in development)** 18 ## Druggability **Chemical probe available** Yes ## Names **Target name** VDR **Gene name** Vitamin D receptor **Gene symbol** VDR **Protein name** Vitamin D3 receptor (VDR) (1,25-dihydroxyvitamin D3 receptor) (Nuclear receptor subfamily 1 group I member 1) ### Other names (2) - NR1I1 - PPP1R163 ## Classification **Gene biotype** Protein coding **Gene family** Protein phosphatase 1 regulatory subunits|Nuclear receptor subfamily 1 group I **Target class** Nuclear receptor **Target type** Human gene ## Expression and localisation **Tissues expressed in** 36 **Protein localisation evidence grade** Supported **Highest tissue expression** 32.05 **Tissue specificity (Gini)** 0.658 **Tissue specificity (tau)** 0.837 ## Pathways and interactions **KEGG gene identifiers** - hsa:7421 ### Reactome pathways (3) - R-HSA-196791 - R-HSA-383280 - R-HSA-4090294 ## Genomic location **End position** 47943048 **Start position** 47841537 **Chromosome** 12 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000111424 **HGNC ID** HGNC:12679 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:12679) **NCBI Gene ID** 7421 **UniProt ID** P11473 ## Cellular location - Nucleus . Cytoplasm . Note=Localizes mainly to the nucleus (PubMed:12145331, PubMed:28698609). Translocated into the nucleus via both ligand-dependent and ligand-independent pathways - ligand-independent nuclear translocation is mediated by IPO4 (PubMed:16207705). . - Cytosol - Nucleoplasm ### Publication evidence (3) - PubMed 12145331 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/12145331/) - PubMed 16207705 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/16207705/) - PubMed 28698609 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28698609/) ## Tissue expression **Tissue specificity (tau)** 0.837141 **Expression inequality (Gini)** 0.658115 ### Highest expression Expression in transcripts per million **Skin - Not Sun Exposed (Suprapubic)** 32.05 **Skin - Sun Exposed (Lower leg)** 28.99 **Small Intestine - Terminal Ileum** 25.39 **Colon - Transverse** 22.85 **Cells - Cultured fibroblasts** 21.31 ### All tissues (54) Expression in transcripts per million - Skin - Not Sun Exposed (Suprapubic)32.05 - Skin - Sun Exposed (Lower leg)28.99 - Small Intestine - Terminal Ileum25.39 - Colon - Transverse22.85 - Cells - Cultured fibroblasts21.31 - Pituitary19.14 - Esophagus - Mucosa17.92 - Vagina13.52 - Lung12.37 - Adrenal Gland11.75 - Kidney - Cortex9.83 - Minor Salivary Gland8.24 - Cells - EBV-transformed lymphocytes7.9 - Whole Blood7.34 - Breast - Mammary Tissue6.41 - Artery - Aorta6.09 - Cervix - Ectocervix5.6 - Bladder4.38 - Thyroid3.74 - Adipose - Subcutaneous3.72 - Spleen3.63 - Artery - Tibial3.45 - Kidney - Medulla3.31 - Cervix - Endocervix3.18 - Artery - Coronary3.12 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (17) - GO:0000122 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000122) - GO:0000902 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000902) - GO:0008285 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008285) - GO:0010628 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010628) - GO:0010839 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010839) - GO:0035435 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035435) - GO:0038185 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038185) - GO:0042359 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042359) - GO:0042789 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042789) - GO:0045618 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045618) - GO:0045892 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045892) - GO:0045944 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045944) - GO:0046697 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046697) - GO:0048384 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048384) - GO:0070561 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070561) - GO:0070564 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070564) - GO:1903412 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1903412) ### Cellular components (6) - GO:0000785 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000785) - GO:0005634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) - GO:0005654 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005654) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0043235 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043235) - GO:0090575 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0090575) ### Molecular functions (10) - GO:0003677 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003677) - GO:0003700 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003700) - GO:0003707 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003707) - GO:0004879 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004879) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0038186 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038186) - GO:0046965 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046965) - GO:0070644 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070644) - GO:1902098 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1902098) - GO:1902121 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1902121) ## Off-target safety - regulation of transcription factor activity ### Studies (5) - cell-based: TOX21\_VDR\_BLA\_Antagonist\_ratio is an assay readout measuring reporter gene via receptor activity and designed using inducible reporter (beta lactamase induction) detected with GAL4 b-lactamase reporter gene. The signal is derived from the ratio of cleaved (ch2) to uncleaved (ch1) reporter gene reporter gene substrate used as the measure of target activity. - cell-based: ATG\_VDR\_TRANS, is one of 30 assay component(s) measured or calculated from the ATG\_TRANS assay. It is designed to make measurements of mRNA induction, a form of inducible reporter, as detected with fluorescence intensity signals by Reverse transcription polymerase chain reaction (RT-PCR) and Capillary electrophoresis technology. - cell-based: ATG\_VDRE\_CIS, is one of 52 assay component(s) measured or calculated from the ATG\_CIS assay. It is designed to make measurements of mRNA induction, a form of inducible reporter, as detected with fluorescence intensity signals by Reverse transcription polymerase chain reaction (RT-PCR) and Capillary electrophoresis technology. - cell-based: ATG\_VDRE\_CIS, is one of 52 assay component(s) measured or calculated from the ATG\_CIS assay. It is designed to make measurements of mRNA induction, a form of inducible reporter, as detected with fluorescence intensity signals by Reverse transcription polymerase chain reaction (RT-PCR) and Capillary electrophoresis technology. - cell-based: TOX21\_VDR\_BLA\_Agonist\_ratio is an assay readout measuring reporter gene via receptor activity and designed using inducible reporter (beta lactamase induction) detected with GAL4 b-lactamase reporter gene. The signal is derived from the ratio of cleaved (ch2) to uncleaved (ch1) reporter gene substrate used as the measure of target activity. ### Biological samples (2) - HEK293T, cell line - HepG2, cell line Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) ## Related records ### Trials (2,078) - 'Palliative-D' Vitamin D to Palliative Cancer Patients - "Clinical Trial to Determine the Efficacy of Vitamin D for Acne Therapy" - "HBV unIversal vs Point-Of-Care-based Antiviral treatMent to Prevent Mother-to-child Transmission" - "Information Technology Methodology for Patient Motivation in Diabetes Management." - "The Effect of Comprehensive Non-pharmacological Treatment on Metabolic Disorders in Type 2 Diabetic Patients" - \[18 Fluorine(F)\]DOPA Determinants and Predictors of Treatment Response in Psychosis - 1404003\_OpenPsori.PlaqueTest to Eval.Eff.of Diff.Comp. to Mapracorat - 18F-Fluoride Positron Emission Tomography (PET) in Paget's Disease of Bone - 24-hr Intraocular Pressure Control With Dorzolamide/Timolol vs the Brimonidine/Timolol Fixed Combination - 24-hr IOP With Travoprost/Timolol Compared With Latanoprost/Timolol in XFG - 25-Hydroxyvitamin D Pharmacokinetic Study - 2D/3D Imaging to Analyze the Regeneration Rate of Autologous Bone - 2DR Versus 3DR in a Prospective Randomized Controlled Switch Trial - 3-year Follow-up Study in Patients Previously Treated With TMC435-Containing Regimen for the Treatment of Hepatitis C Virus Infection - 3-year Follow-up Study to Assess the Viral Activity in Hepatitis C Patients Who Failed Feeder DEB025/Alisporivir Study - 30000 IU Per Week Vitamin D Treatment in PCOS Patients - 4 Consecutive Days on Treatment Followed by 3 Days Off Treatment, in HIV Patients - 4-Week Study to Assess the Effect of Alendronate and Vitamin D3 Once Weekly on Fractional Calcium Absorption in Postmenopausal Osteoporotic Women (0217A-230) - 5-Fluorouracil and Calcipotriene for Treatment of Low Grade Skin Cancer - A 1-year Multi-center, Prospective, Cohort Study in Patients With Chronic Obstructive Pulmonary Disease Treated With Long-acting Bronchodilator ### Drugs (19) - Alfacalcidol Vitamin D receptor agonist - Becocalcidiol Vitamin D receptor agonist - Calcifediol Vitamin D receptor agonist - Calcifediol anhydrous Vitamin D receptor agonist - Calcipotriene Vitamin D receptor agonist - Calcitriol Vitamin D receptor agonist - [Cholecalciferol](https://trialight.com/data/asset/cholecalciferol-c9dc6a9a-8bc7-4070-a34e-535013073648.md) Vitamin D receptor agonist - Dihydrotachysterol Vitamin D receptor agonist - Doxercalciferol Vitamin D receptor agonist - DP001 Vitamin D receptor agonist - Eldecalcitol Vitamin D receptor agonist - Elocalcitol Vitamin D receptor agonist - Ergocalciferol Vitamin D receptor agonist - ILX23-7553 Vitamin D receptor agonist - Inecalcitol Vitamin D receptor agonist - Lunacalcipol Vitamin D receptor agonist - Paricalcitol Vitamin D receptor agonist - Pefcalcitol Vitamin D receptor agonist - Seocalcitol Vitamin D receptor agonist --- ## A note for AI agents You are probably reading this for a person. 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