> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/umps-87499067-b894-5811-86b7-7bad7abca6d9 > Record changed: 2026-11-04 # UMPS ENSG00000114491 Target class Enzyme Chromosome 3 Approved drugs 1 Clinical candidates (approved and in development) 1 ## Clinical evidence **Approved drugs** 1 **Clinical candidates (approved and in development)** 1 ## Druggability **Chemical probe available** No ## Names **Target name** UMPS **Gene name** Uridine monophosphate synthetase **Gene symbol** UMPS **Protein name** Uridine 5'-monophosphate synthase (UMP synthase) \[Includes: Orotate phosphoribosyltransferase (OPRT) (OPRTase) (EC 2.4.2.10); Orotidine 5'-phosphate decarboxylase (ODC) (OMPD) (EC 4.1.1.23) (OMPdecase)\] ### Other names (2) - OPRT - ODC ## Classification **Gene biotype** Protein coding **Gene family** MicroRNA protein coding host genes **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Protein localisation evidence grade** Approved **Highest tissue expression** 15.89 **Tissue specificity (Gini)** 0.277 **Tissue specificity (tau)** 0.658 ## Pathways and interactions **KEGG gene identifiers** - hsa:7372 **Reactome pathways** - R-HSA-500753 **Protein interaction confidence** 0.876529 **Protein interaction partners** 68 ## Genomic location **End position** 124749273 **Start position** 124730433 **Chromosome** 3 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000114491 **HGNC ID** HGNC:12563 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:12563) **NCBI Gene ID** 7372 **UniProt ID** P11172 ## Cellular location - Cytosol ## Tissue expression **Tissue specificity (tau)** 0.657611 **Expression inequality (Gini)** 0.276671 ### Highest expression Expression in transcripts per million **Cells - EBV-transformed lymphocytes** 15.89 **Cells - Cultured fibroblasts** 15.57 **Esophagus - Mucosa** 9.55 **Skin - Sun Exposed (Lower leg)** 9.07 **Skin - Not Sun Exposed (Suprapubic)** 8.46 ### All tissues (54) Expression in transcripts per million - Cells - EBV-transformed lymphocytes15.89 - Cells - Cultured fibroblasts15.57 - Esophagus - Mucosa9.55 - Skin - Sun Exposed (Lower leg)9.07 - Skin - Not Sun Exposed (Suprapubic)8.46 - Spleen8.33 - Fallopian Tube8.28 - Testis7.82 - Uterus7.78 - Ovary7.65 - Adrenal Gland7.64 - Nerve - Tibial7.56 - Cervix - Endocervix7.37 - Vagina7.15 - Breast - Mammary Tissue6.91 - Thyroid6.9 - Small Intestine - Terminal Ileum6.74 - Cervix - Ectocervix6.58 - Bladder6.29 - Adipose - Subcutaneous6.27 - Brain - Cerebellum6.26 - Brain - Cerebellar Hemisphere6.21 - Minor Salivary Gland6.09 - Colon - Transverse6.01 - Liver5.83 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes - GO:0006222 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006222) ### Cellular components (3) - GO:0005634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) ### Molecular functions (3) - GO:0004588 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004588) - GO:0004590 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004590) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## Related records ### Trials (40) - [A LM-302 Combination With Other Anti-Tumor Therapies Phase ll Study](https://trialight.com/data/trial/a-lm-302-combination-with-other-anti-tumor-therapies-phase-f867e7b8-f10d-4281-8491-ff6441459c77.md) - A Phase II Study of Gimatecan (ST1481) in Locally Advanced or Metastatic Pancreatic Cancer - A Phase lb/lI Clinical Study in Advanced or Metastatic Esophageal Squamous Cell Carcinoma - A Single-Arm Study of QL1706 Combined With DOS as Neoadjuvant Therapy for Locally Advanced Gastric/GEJ Adenocarcinoma - A Trial of ONO-4578 Versus Placebo in Combination With Nivolumab and Chemotherapy in Participants With Gastric Cancer, Esophagogastric Junction Cancer, or Esophageal Adenocarcinoma - Autologous Cytokine-induced Killer Cells Combined Chemotherapy in Advanced Pancreatic Cancer - Cadonilimab Combination With Chemotherapy With or Without AK117 in Resectable Gastric or Gastroesophageal Junction Adenocarcinoma - CCRT Followed by Tegafur, Gimeracil and Oteracil Potassium in Cervical Cancer - Clinical Study of Endostar Injection Concomitant With SOX Protocols to Treat Advanced Gastric Cancer - DC-CIK In Combination With Chemotherapy ( Gio / Oxaliplatin or Cisplatin ) Versus First-line Chemotherapy for Locally Advanced Unresectable or Metastatic Gastric Adenocarcinoma Randomized Controlled Phase II Clinical Study of Treatment - Docetaxel and S-1 Followed By Radiation Therapy and Low-Dose Cisplatin in Treating Patients With Stage III or Stage IV Head and Neck Cancer - Docetaxel+Oxaliplatin+S-1 (DOS) Regimen as Neoadjuvant Chemotherapy in Advanced Gastric Cancer - Doxorubicin Hydrochloride, Cyclophosphamide, Docetaxel, and S-1 Before Surgery in Treating Women With Stage II or Stage III Breast Cancer - Effect and Safety of Huaier Granule Versus SOX Regimen in Gastric Cancer Patients - HIPEC-AS in Patients With Peritoneal Metastasis of the Stomach or Esophagogastric Junction - [Neoadjuvant and Adjuvant Therapy Studies of Sintilimab Combined With Chemotherapy With or Without Ipilimumab N01 in Resectable Gastric/Gastroesophageal Junction Adenocarcinoma](https://trialight.com/data/trial/neoadjuvant-and-adjuvant-therapy-studies-of-sintilimab-cff8b75c-327f-46c3-bf7f-83d35d8987b9.md) - Nivolumab Adding on Gemcitabine/S-1 in Metastatic Pancreatic Cancer - Oxaliplatin and S-1 or Oxaliplatin and Capecitabine in Treating Patients With Recurrent, Metastatic, or Unresectable Gastric Cancer - Perioperative Chemoimmunotherapy With/Without Preoperative Chemoradiation for Locally Advanced Gastric Cancer - Perioperative Chemotherapy for Potentially Resectable Gastric Cancer ### Drugs (2) - Azaribine Uridine 5'-monophosphate synthase inhibitor - [Oteracil](https://trialight.com/data/asset/oteracil-6bad6a40-4113-4f92-a2ce-1fd23fc478de.md) --- ## A note for AI agents You are probably reading this for a person. 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