> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/tyk2-b41bcab9-b384-5a30-9edf-ec61d7908e06 > Record changed: 2026-10-13 # TYK2 ENSG00000105397 Target class Kinase Chromosome 19 Approved drugs 7 Clinical candidates (approved and in development) 14 ## Clinical evidence **Approved drugs** 7 **Clinical candidates (approved and in development)** 14 ## Druggability **Chemical probe available** Yes ## Names **Other names** - JTK1 **Target name** TYK2 **Gene name** Tyrosine kinase 2 **Gene symbol** TYK2 **Protein name** Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2) ## Classification **Gene biotype** Protein coding **Gene family** FERM domain containing|Jak family tyrosine kinases **Target class** Kinase **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Protein localisation evidence grade** Approved **Highest tissue expression** 100.47 **Tissue specificity (Gini)** 0.298 **Tissue specificity (tau)** 0.643 ## Pathways and interactions **KEGG gene identifiers** - hsa:7297 **Protein interaction confidence** 0.853047 **Protein interaction partners** 107 ### Reactome pathways (21) - R-HSA-1059683 - R-HSA-110056 - R-HSA-112411 - R-HSA-449836 - R-HSA-6783783 - R-HSA-6785807 - R-HSA-6788467 - R-HSA-8854691 - R-HSA-8984722 - R-HSA-9020591 - R-HSA-9020933 - R-HSA-9020956 - R-HSA-909733 - R-HSA-912694 - R-HSA-9674555 - R-HSA-9679191 - R-HSA-9705462 - R-HSA-9705671 - R-HSA-9725370 - R-HSA-9833109 - R-HSA-9958825 ## Genomic location **End position** 10380608 **Start position** 10350528 **Chromosome** 19 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000105397 **HGNC ID** HGNC:12440 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:12440) **NCBI Gene ID** 7297 **UniProt ID** P29597 ## Cellular location - Cytosol ## Tissue expression **Tissue specificity (tau)** 0.642743 **Expression inequality (Gini)** 0.298022 ### Highest expression Expression in transcripts per million **Cells - EBV-transformed lymphocytes** 100.47 **Spleen** 95 **Whole Blood** 78.64 **Lung** 65.86 **Nerve - Tibial** 65.39 ### All tissues (54) Expression in transcripts per million - Cells - EBV-transformed lymphocytes100.47 - Spleen95 - Whole Blood78.64 - Lung65.86 - Nerve - Tibial65.39 - Thyroid61.37 - Cervix - Endocervix58.88 - Ovary55.75 - Brain - Cerebellum53.94 - Pituitary53.24 - Uterus52.79 - Cervix - Ectocervix50.28 - Prostate50.07 - Small Intestine - Terminal Ileum49.12 - Brain - Cerebellar Hemisphere48.47 - Fallopian Tube48.43 - Adipose - Subcutaneous44.62 - Breast - Mammary Tissue44.6 - Cells - Cultured fibroblasts42.65 - Bladder41.84 - Vagina41.23 - Skin - Sun Exposed (Lower leg)40.34 - Minor Salivary Gland40.02 - Skin - Not Sun Exposed (Suprapubic)38.3 - Adipose - Visceral (Omentum)36.82 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (9) - GO:0006468 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006468) - GO:0007259 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007259) - GO:0019221 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019221) - GO:0035722 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035722) - GO:0038155 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038155) - GO:0060333 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060333) - GO:0060337 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060337) - GO:0140105 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0140105) - GO:1900182 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1900182) ### Cellular components (8) - GO:0005634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0009898 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009898) - GO:0019897 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019897) - GO:0031234 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031234) - GO:0070062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062) ### Molecular functions (4) - GO:0004713 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004713) - GO:0004715 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004715) - GO:0005131 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005131) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## Related records ### Trials (574) - 3T Therapy in the Treatment of MDA5-positive Dermatomyositis - 68Ga-THP-PSMA PET/CT in Prostate Cancer: Clinical Stage and Restage - A 12 Day Study To Evaluate A Topical Drug To Treat Plaque Psoriasis - A 12-Week Open-Label Study to Investigate the Efficacy and Safety of Brepocitinib in Adults With Skin-Predominant Dermatomyositis - A 16-week Trial to Investigate the Efficacy and Safety of Delgocitinib Cream 20 mg/g in Adult Participants With Mild to Severe Palmoplantar Pustulosis - A 2-Year Phase 3 Study Of CP-690,550 In Patients With Active Rheumatoid Arthritis On Background Methotrexate - A 24 Week Trial to Compare the Efficacy and Safety of Delgocitinib Cream 20 mg/g Twice-daily With Alitretinoin Capsules Once-daily in Adult Participants With Severe Chronic Hand Eczema - A 44-week Monocentric Open Study Assessing the Efficacy and Safety of Deucravacitinib in Adults With Inflammatory Genodermatoses - A 52-Week Trial to Investigate the Efficacy and Safety of Delgocitinib Cream in Adult Participants With Lichen Sclerosus - A 6-Month Study Of CP-690,550 Versus Tacrolimus In Kidney Transplant Patients - A Clinical Study to Evaluate the Efficacy and Safety of D-2570 in the Treatment of Moderate to Severe Plaque Psoriasis - A Clinical Trial of TQH3906 Capsules in Adult Patients With Moderate to Severe Plaque Psoriasis - A Clinical Trial of TQH3906 Capsules in the Treatment of Active Psoriatic Arthritis - A DOSE-RANGING STUDY TO EVALUATE EFFICACY AND SAFETY OF PF-06700841 IN SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) - A Drug Drug Interaction Study Between PF-06826647 And Oral Contraceptive Steroids In Healthy Female Participants - A Drug Interaction Study to Evaluate the Pharmacokinetics of ASP015K and Metformin - A Drug Interaction Study to Evaluate the Pharmacokinetics of ASP015K and Methotrexate in Patients With Rheumatoid Arthritis - A First in Human Study to Evaluate Safety, Tolerability, and Pharmacology of PF-06826647 in Healthy Subjects and Subjects With Plaque Psoriasis - A Long Term Study To Evaluate The Safety And Tolerability Of CP-690,550 For Patients With Moderate To Severe Chronic Plaque Psoriasis - A Long Term Study To Evaluate The Safety, Tolerability And Efficacy Of CP-690,550 In Patients With Moderate To Severe Plaque Psoriasis And/Or Psoriatic Arthritis ### Drugs (18) - Brepocitinib Tyrosine-protein kinase TYK2 inhibitor - Cerdulatinib Tyrosine-protein kinase TYK2 inhibitor - Cravacitinib Tyrosine-protein kinase TYK2 negative allosteric modulator - Delgocitinib Janus Kinase (JAK) inhibitor - [Deucravacitinib](https://trialight.com/data/asset/deucravacitinib-3033fa9d-d652-4397-81c1-5e76480167af.md) Tyrosine-protein kinase TYK2 negative allosteric modulator - Deuruxolitinib phosphate Tyrosine-protein kinase TYK2 inhibitor - Filgotinib Tyrosine-protein kinase TYK2 inhibitor - Filgotinib maleate Tyrosine-protein kinase TYK2 inhibitor - Gusacitinib Janus Kinase (JAK) inhibitor - Izencitinib Janus Kinase (JAK) inhibitor - Nezulcitinib Janus Kinase (JAK) inhibitor - Peficitinib Janus Kinase (JAK) inhibitor - Ropsacitinib Tyrosine-protein kinase TYK2 inhibitor - [Ruxolitinib](https://trialight.com/data/asset/ruxolitinib-3ab34d42-3776-4160-9bc2-d149204acfd5.md) Tyrosine-protein kinase TYK2 inhibitor - Tofacitinib Janus Kinase (JAK) inhibitor - Tofacitinib citrate Janus Kinase (JAK) inhibitor - Upadacitinib Tyrosine-protein kinase TYK2 inhibitor - Upadacitinib hemihydrate Tyrosine-protein kinase TYK2 inhibitor --- ## A note for AI agents You are probably reading this for a person. 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