> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/tubb8-f8700f93-4301-5eda-9407-55f76aa16a06 > Record changed: 2026-10-13 # TUBB8 ENSG00000261456 Target class Structural protein Chromosome 10 Approved drugs 19 Clinical candidates (approved and in development) 84 ## Clinical evidence **Approved drugs** 19 **Clinical candidates (approved and in development)** 84 ## Druggability **Chemical probe available** No ## Names **Other names** - bA631M21.2 **Target name** TUBB8 **Gene name** Tubulin beta 8 class VIII **Gene symbol** TUBB8 **Protein name** Tubulin beta-8 chain (Tubulin beta 8 class VIII) ## Classification **Gene biotype** Protein coding **Gene family** Tubulin beta family **Target class** Structural protein **Target type** Human gene ## Expression and localisation **Tissues expressed in** 1 **Protein localisation evidence grade** Supported **Highest tissue expression** 1.88 **Tissue specificity (Gini)** 0.609 **Tissue specificity (tau)** 0.944 ## Pathways and interactions **KEGG gene identifiers** - hsa:347688 **Protein interaction confidence** 0.873333 **Protein interaction partners** 18 ### Reactome pathways (26) - R-HSA-1445148 - R-HSA-190840 - R-HSA-190861 - R-HSA-2132295 - R-HSA-2467813 - R-HSA-2500257 - R-HSA-3371497 - R-HSA-380320 - R-HSA-437239 - R-HSA-5620920 - R-HSA-5626467 - R-HSA-5663220 - R-HSA-6807878 - R-HSA-6811434 - R-HSA-6811436 - R-HSA-68877 - R-HSA-8852276 - R-HSA-8955332 - R-HSA-9609690 - R-HSA-9609736 - R-HSA-9619483 - R-HSA-9646399 - R-HSA-9648025 - R-HSA-9668328 - R-HSA-983189 And 1 more, listed on the interactive page. ## Genomic location **End position** 74163 **Start position** 46888 **Chromosome** 10 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000261456 **HGNC ID** HGNC:20773 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:20773) **NCBI Gene ID** 347688 **UniProt ID** Q3ZCM7 ## Cellular location - Cytoplasm, cytoskeleton . Cytoplasm, cytoskeleton, spindle . - Basal body - Cytokinetic bridge - End piece - Flagellar centriole - Microtubules - Mitotic spindle - Primary cilium - Primary cilium tip - Principal piece ### Publication evidence - PubMed 26789871 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/26789871/) ## Tissue expression **Tissue specificity (tau)** 0.944099 **Expression inequality (Gini)** 0.608973 ### Highest expression Expression in transcripts per million **Testis** 1.88 **Thyroid** 0.91 **Kidney - Medulla** 0.52 **Breast - Mammary Tissue** 0.25 **Brain - Nucleus accumbens (basal ganglia)** 0.24 ### All tissues (54) Expression in transcripts per million - Testis1.88 - Thyroid0.91 - Kidney - Medulla0.52 - Breast - Mammary Tissue0.25 - Brain - Nucleus accumbens (basal ganglia)0.24 - Fallopian Tube0.22 - Pituitary0.17 - Cervix - Endocervix0.16 - Brain - Frontal Cortex (BA9)0.15 - Brain - Hypothalamus0.15 - Ovary0.14 - Brain - Caudate (basal ganglia)0.14 - Brain - Cortex0.13 - Prostate0.13 - Kidney - Cortex0.13 - Brain - Anterior cingulate cortex (BA24)0.12 - Adipose - Visceral (Omentum)0.11 - Brain - Amygdala0.11 - Brain - Hippocampus0.1 - Brain - Spinal cord (cervical c-1)0.09 - Brain - Putamen (basal ganglia)0.09 - Cervix - Ectocervix0.09 - Uterus0.09 - Bladder0.09 - Brain - Substantia nigra0.09 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (2) - GO:0001556 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001556) - GO:0007056 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007056) ### Cellular components (9) - GO:0005929 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005929) - GO:0015630 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015630) - GO:0045171 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045171) - GO:0070062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062) - GO:0072686 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0072686) - GO:0072687 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0072687) - GO:0097228 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097228) - GO:0097229 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097229) - GO:0097542 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097542) ### Molecular functions - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## Related records ### Trials (9,123) - 'ADVANCE' (A Pilot Trial) - "Curcumin" in Combination With Chemotherapy in Advanced Breast Cancer - "Phase II Study of PET Guided Neoadjuvant Chemotherapy (NAC) and Oncotype Guided Hormonal Therapy of Breast Cancer" - "Prevention of Paclitaxel-Induced Peripheral Neuropathy in Breast Cancer Patients" - \[18F\]FLT PET/CT in Rb+ Metastatic Breast Cancer - \[18F\]Fluciclatide-PET, Pazopanib and Paclitaxel in Ovarian Cancer - 05-001: Treatment of Acute Lymphoblastic Leukemia in Children - 0822GCC: Phase 2 Study of Efficacy and Safety of Apricoxib/Placebo With Docetaxel or Pemetrexed in Non-Small Cell Lung Cancer - 1 or 6 Months of Dual Antiplatelet Therapy After Drug-coated Balloon Angioplasty for De-novo Small Coronary Artery Disease - 1-Methyl-D-Tryptophan and Docetaxel in Treating Patients With Metastatic Solid Tumors - 12 weekS Adjuvant dOcetaxel Plus trastuzumaB in Patients With Small, Node-negative, HER2-positive Breast cancER (SOBER) - 1303GCC: Trastuzmab & Pertuzumab With Hormonal Therapy or Chemotherapy in Women Aged 60 and Over. - 131I-MIBG Alone VS. 131I-MIBG With Vincristine and Irinotecan VS131I-MIBG With Vorinostat - 17-N-Allylamino-17-Demethoxygeldanamycin and Paclitaxel in Treating Patients With Metastatic or Unresectable Solid Tumor - 177 LuPSMA-617 vs Docetaxel in Metastatic Castration Resistant and PSMA-Positive Prostate Cancer - 1st Line Treatment of Bevacizumab-Taxane vs Bevacizumab-Exemestane in Metastatic Breast Cancer - 2-arm Trial of Paclitaxel Plus Bevacizumab vs. Capecitabine Plus Bevacizumab - 24BRO681 : Alternating Gnp and mFOLFIRINOX for BR-PDAC - 2nd Line Erlotinib Treatment With (Out) Chemotherapy of Advanced Non Small Cell Lung Cancer (NSCLC) - 3-AP Plus Cisplatin and Paclitaxel in Treating Patients With Advanced or Metastatic Cancer ### Drugs (89) - ABT-751 Tubulin beta inhibitor - AGS-16C3F Tubulin disrupting agent - Anetumab ravtansine Tubulin inhibitor - ANG1005 Tubulin inhibitor - Anvatabart opadotin Tubulin inhibitor - Aprutumab ixadotin Tubulin inhibitor - ASG-5ME Tubulin inhibitor - AVE-9633 Tubulin inhibitor - Azintuxizumab vedotin Tubulin inhibitor - Belantamab mafodotin Tubulin inhibitor - BIIB-015 Tubulin inhibitor - Bivatuzumab mertansine Tubulin inhibitor - BMS-275183 Tubulin stabiliser - [Brentuximab vedotin](https://trialight.com/data/asset/brentuximab-vedotin-b112eac4-7573-41dc-af6c-6c9212132a79.md) Tubulin inhibitor - [Cabazitaxel](https://trialight.com/data/asset/cabazitaxel-9437ae6b-3713-457c-b52b-a71e10a81dde.md) Tubulin inhibitor - Cantuzumab mertansine Tubulin inhibitor - Cantuzumab ravtansine Tubulin inhibitor - [Colchicine](https://trialight.com/data/asset/colchicine-ae804b3e-3263-453f-abb3-ae1e813f2ccf.md) Tubulin inhibitor - Coltuximab ravtansine Tubulin inhibitor - Crolibulin Tubulin inhibitor --- ## A note for AI agents You are probably reading this for a person. 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