> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/tubb4a-ad5f7184-fd22-58b7-a66c-95289ce2e093 > Record changed: 2026-10-13 # TUBB4A ENSG00000104833 Target class Structural protein Chromosome 19 Approved drugs 19 Clinical candidates (approved and in development) 84 ## Clinical evidence **Approved drugs** 19 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 84 ## Druggability **Chemical probe available** No ## Names **Other names** - beta-5 **Target name** TUBB4A **Gene name** Tubulin beta 4A class IVa **Gene symbol** TUBB4A **Protein name** Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain) ### Previous gene symbols (2) - TUBB4 - DYT4 ## Classification **Gene biotype** Protein coding **Gene family** Tubulin beta family **Target class** Structural protein **Target type** Human gene ## Expression and localisation **Tissues expressed in** 27 **Protein localisation evidence grade** Supported **Highest tissue expression** 988.75 **Tissue specificity (Gini)** 0.824 **Tissue specificity (tau)** 0.933 ## Pathways and interactions **KEGG gene identifiers** - hsa:10382 **Protein interaction confidence** 0.8487 **Protein interaction partners** 30 ### Reactome pathways (37) - R-HSA-1445148 - R-HSA-190840 - R-HSA-190861 - R-HSA-2132295 - R-HSA-2467813 - R-HSA-2500257 - R-HSA-2565942 - R-HSA-3371497 - R-HSA-380259 - R-HSA-380270 - R-HSA-380284 - R-HSA-380320 - R-HSA-389957 - R-HSA-389960 - R-HSA-389977 - R-HSA-437239 - R-HSA-5610787 - R-HSA-5620912 - R-HSA-5620920 - R-HSA-5620924 - R-HSA-5626467 - R-HSA-5663220 - R-HSA-6807878 - R-HSA-6811434 - R-HSA-6811436 And 12 more, listed on the interactive page. ## Genomic location **End position** 6502848 **Start position** 6494319 **Chromosome** 19 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000104833 **HGNC ID** HGNC:20774 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:20774) **NCBI Gene ID** 10382 **UniProt ID** P04350 ## Cellular location - Cytoplasm, cytoskeleton. - Basal body - Cytokinetic bridge - End piece - Flagellar centriole - Microtubules - Mitotic spindle - Primary cilium - Primary cilium tip - Principal piece ## Tissue expression **Tissue specificity (tau)** 0.932633 **Expression inequality (Gini)** 0.824425 ### Highest expression Expression in transcripts per million **Brain - Cerebellar Hemisphere** 988.75 **Brain - Cerebellum** 895.32 **Brain - Spinal cord (cervical c-1)** 446.23 **Brain - Frontal Cortex (BA9)** 305.65 **Brain - Cortex** 258.5 ### All tissues (54) Expression in transcripts per million - Brain - Cerebellar Hemisphere988.75 - Brain - Cerebellum895.32 - Brain - Spinal cord (cervical c-1)446.23 - Brain - Frontal Cortex (BA9)305.65 - Brain - Cortex258.5 - Brain - Substantia nigra186.65 - Brain - Hippocampus185.54 - Brain - Hypothalamus176.08 - Brain - Nucleus accumbens (basal ganglia)174.77 - Brain - Caudate (basal ganglia)170.04 - Brain - Anterior cingulate cortex (BA24)168.73 - Brain - Putamen (basal ganglia)168.28 - Brain - Amygdala131.6 - Adrenal Gland109.64 - Testis80.06 - Nerve - Tibial30.81 - Spleen6.77 - Colon - Sigmoid4.81 - Cells - EBV-transformed lymphocytes2.55 - Esophagus - Muscularis2.18 - Esophagus - Gastroesophageal Junction2.11 - Colon - Transverse1.99 - Small Intestine - Terminal Ileum1.58 - Skin - Sun Exposed (Lower leg)1.5 - Pituitary1.3 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes - GO:0031115 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031115) ### Cellular components (12) - GO:0005634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0005874 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005874) - GO:0005929 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005929) - GO:0005930 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005930) - GO:0015630 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015630) - GO:0045171 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045171) - GO:0070062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062) - GO:0072686 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0072686) - GO:0097228 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097228) - GO:0097229 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097229) - GO:0097542 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097542) ### Molecular functions (2) - GO:0005509 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005509) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## Related records ### Trials (9,123) - 'ADVANCE' (A Pilot Trial) - "Curcumin" in Combination With Chemotherapy in Advanced Breast Cancer - "Phase II Study of PET Guided Neoadjuvant Chemotherapy (NAC) and Oncotype Guided Hormonal Therapy of Breast Cancer" - "Prevention of Paclitaxel-Induced Peripheral Neuropathy in Breast Cancer Patients" - \[18F\]FLT PET/CT in Rb+ Metastatic Breast Cancer - \[18F\]Fluciclatide-PET, Pazopanib and Paclitaxel in Ovarian Cancer - 05-001: Treatment of Acute Lymphoblastic Leukemia in Children - 0822GCC: Phase 2 Study of Efficacy and Safety of Apricoxib/Placebo With Docetaxel or Pemetrexed in Non-Small Cell Lung Cancer - 1 or 6 Months of Dual Antiplatelet Therapy After Drug-coated Balloon Angioplasty for De-novo Small Coronary Artery Disease - 1-Methyl-D-Tryptophan and Docetaxel in Treating Patients With Metastatic Solid Tumors - 12 weekS Adjuvant dOcetaxel Plus trastuzumaB in Patients With Small, Node-negative, HER2-positive Breast cancER (SOBER) - 1303GCC: Trastuzmab & Pertuzumab With Hormonal Therapy or Chemotherapy in Women Aged 60 and Over. - 131I-MIBG Alone VS. 131I-MIBG With Vincristine and Irinotecan VS131I-MIBG With Vorinostat - 17-N-Allylamino-17-Demethoxygeldanamycin and Paclitaxel in Treating Patients With Metastatic or Unresectable Solid Tumor - 177 LuPSMA-617 vs Docetaxel in Metastatic Castration Resistant and PSMA-Positive Prostate Cancer - 1st Line Treatment of Bevacizumab-Taxane vs Bevacizumab-Exemestane in Metastatic Breast Cancer - 2-arm Trial of Paclitaxel Plus Bevacizumab vs. Capecitabine Plus Bevacizumab - 24BRO681 : Alternating Gnp and mFOLFIRINOX for BR-PDAC - 2nd Line Erlotinib Treatment With (Out) Chemotherapy of Advanced Non Small Cell Lung Cancer (NSCLC) - 3-AP Plus Cisplatin and Paclitaxel in Treating Patients With Advanced or Metastatic Cancer ### Drugs (89) - ABT-751 Tubulin beta inhibitor - AGS-16C3F Tubulin disrupting agent - Anetumab ravtansine Tubulin inhibitor - ANG1005 Tubulin inhibitor - Anvatabart opadotin Tubulin inhibitor - Aprutumab ixadotin Tubulin inhibitor - ASG-5ME Tubulin inhibitor - AVE-9633 Tubulin inhibitor - Azintuxizumab vedotin Tubulin inhibitor - Belantamab mafodotin Tubulin inhibitor - BIIB-015 Tubulin inhibitor - Bivatuzumab mertansine Tubulin inhibitor - BMS-275183 Tubulin stabiliser - [Brentuximab vedotin](https://trialight.com/data/asset/brentuximab-vedotin-b112eac4-7573-41dc-af6c-6c9212132a79.md) Tubulin inhibitor - [Cabazitaxel](https://trialight.com/data/asset/cabazitaxel-9437ae6b-3713-457c-b52b-a71e10a81dde.md) Tubulin inhibitor - Cantuzumab mertansine Tubulin inhibitor - Cantuzumab ravtansine Tubulin inhibitor - [Colchicine](https://trialight.com/data/asset/colchicine-ae804b3e-3263-453f-abb3-ae1e813f2ccf.md) Tubulin inhibitor - Coltuximab ravtansine Tubulin inhibitor - Crolibulin Tubulin inhibitor --- ## A note for AI agents You are probably reading this for a person. 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