TUBB3
ENSG00000258947
Target class
Structural protein
Chromosome
16
Approved drugs
19
Clinical candidates (approved and in development)
84
- Approved drugs
- 19
- ClinGen gene-disease validity
- Definitive
- Clinical candidates (approved and in development)
- 84
- Chemical probe available
- Yes
- Target name
- TUBB3
- Gene name
- Tubulin beta 3 class III
- Gene symbol
- TUBB3
- Previous gene symbols
- FEOM3
- Protein name
- Tubulin beta-3 chain (Tubulin beta-4 chain) (Tubulin beta-III)
- beta-4
- CFEOM3
- CFEOM3A
- Gene biotype
- Protein coding
- Gene family
- Tubulin beta family
- Target class
- Structural protein
- Target type
- Human gene
- Tissues expressed in
- 46
- Protein localisation evidence grade
- Supported
- Highest tissue expression
- 143.84
- Tissue specificity (Gini)
- 0.727
- Tissue specificity (tau)
- 0.866
- KEGG gene identifiers
- hsa:10381
- Protein interaction confidence
- 0.834692
- Protein interaction partners
- 39
- R-HSA-1445148
- R-HSA-190840
- R-HSA-190861
- R-HSA-2132295
- R-HSA-2467813
- R-HSA-2500257
- R-HSA-3371497
- R-HSA-380320
- R-HSA-389957
- R-HSA-389960
- R-HSA-389977
- R-HSA-437239
- R-HSA-5610787
- R-HSA-5620920
- R-HSA-5620924
- R-HSA-5626467
- R-HSA-5663220
- R-HSA-6807878
- R-HSA-6811434
- R-HSA-6811436
- R-HSA-68877
- R-HSA-8852276
- R-HSA-8955332
- R-HSA-9609690
- R-HSA-9609736
And 6 more, listed on the interactive page.
- End position
- 89938761
- Start position
- 89921392
- Chromosome
- 16
- Strand
- Forward
- Cytoplasm, cytoskeleton . Cell projection, growth cone . Cell projection, lamellipodium . Cell projection, filopodium .
- Basal body
- Cytokinetic bridge
- End piece
- Flagellar centriole
- Microtubules
- Mitotic spindle
- Primary cilium
- Primary cilium tip
- Principal piece
- PubMed 34996871
- PubMed 35482892
- Tissue specificity (tau)
- 0.865935
- Expression inequality (Gini)
- 0.727375
Expression in transcripts per million
- Brain - Hypothalamus
- 143.84
- Brain - Frontal Cortex (BA9)
- 123.07
- Brain - Cortex
- 102
- Brain - Cerebellar Hemisphere
- 101.15
- Brain - Cerebellum
- 100.97
Expression in transcripts per million
- Brain - Hypothalamus143.84
- Brain - Frontal Cortex (BA9)123.07
- Brain - Cortex102
- Brain - Cerebellar Hemisphere101.15
- Brain - Cerebellum100.97
- Brain - Anterior cingulate cortex (BA24)79.07
- Brain - Substantia nigra61.4
- Cells - Cultured fibroblasts48.02
- Brain - Nucleus accumbens (basal ganglia)45.95
- Testis45.87
- Brain - Amygdala45.86
- Brain - Hippocampus45.46
- Pituitary38.06
- Brain - Caudate (basal ganglia)36.73
- Brain - Putamen (basal ganglia)32.36
- Brain - Spinal cord (cervical c-1)24.08
- Colon - Sigmoid12.71
- Adrenal Gland8.74
- Colon - Transverse6
- Esophagus - Muscularis5.12
- Esophagus - Gastroesophageal Junction4.26
- Cervix - Endocervix3.52
- Small Intestine - Terminal Ileum3.47
- Skin - Sun Exposed (Lower leg)3.38
- Nerve - Tibial3.16
And 29 more, listed on the interactive page.
- GO:0000226
- GO:0007411
- GO:1990791
- GO:0005634
- GO:0005874
- GO:0005929
- GO:0015630
- GO:0045171
- GO:0070062
- GO:0072686
- GO:0097228
- GO:0097229
- GO:0097542
- GO:0005200
- GO:0005515
- GO:0005525
- GO:1990890
Related records
Trials (9,123)
- 'ADVANCE' (A Pilot Trial)
- "Curcumin" in Combination With Chemotherapy in Advanced Breast Cancer
- "Phase II Study of PET Guided Neoadjuvant Chemotherapy (NAC) and Oncotype Guided Hormonal Therapy of Breast Cancer"
- "Prevention of Paclitaxel-Induced Peripheral Neuropathy in Breast Cancer Patients"
- [18F]FLT PET/CT in Rb+ Metastatic Breast Cancer
- [18F]Fluciclatide-PET, Pazopanib and Paclitaxel in Ovarian Cancer
- 05-001: Treatment of Acute Lymphoblastic Leukemia in Children
- 0822GCC: Phase 2 Study of Efficacy and Safety of Apricoxib/Placebo With Docetaxel or Pemetrexed in Non-Small Cell Lung Cancer
- 1 or 6 Months of Dual Antiplatelet Therapy After Drug-coated Balloon Angioplasty for De-novo Small Coronary Artery Disease
- 1-Methyl-D-Tryptophan and Docetaxel in Treating Patients With Metastatic Solid Tumors
- 12 weekS Adjuvant dOcetaxel Plus trastuzumaB in Patients With Small, Node-negative, HER2-positive Breast cancER (SOBER)
- 1303GCC: Trastuzmab & Pertuzumab With Hormonal Therapy or Chemotherapy in Women Aged 60 and Over.
- 131I-MIBG Alone VS. 131I-MIBG With Vincristine and Irinotecan VS131I-MIBG With Vorinostat
- 17-N-Allylamino-17-Demethoxygeldanamycin and Paclitaxel in Treating Patients With Metastatic or Unresectable Solid Tumor
- 177 LuPSMA-617 vs Docetaxel in Metastatic Castration Resistant and PSMA-Positive Prostate Cancer
- 1st Line Treatment of Bevacizumab-Taxane vs Bevacizumab-Exemestane in Metastatic Breast Cancer
- 2-arm Trial of Paclitaxel Plus Bevacizumab vs. Capecitabine Plus Bevacizumab
- 24BRO681 : Alternating Gnp and mFOLFIRINOX for BR-PDAC
- 2nd Line Erlotinib Treatment With (Out) Chemotherapy of Advanced Non Small Cell Lung Cancer (NSCLC)
- 3-AP Plus Cisplatin and Paclitaxel in Treating Patients With Advanced or Metastatic Cancer
Drugs (89)
- ABT-751 Tubulin beta inhibitor
- AGS-16C3F Tubulin disrupting agent
- Anetumab ravtansine Tubulin inhibitor
- ANG1005 Tubulin inhibitor
- Anvatabart opadotin Tubulin inhibitor
- Aprutumab ixadotin Tubulin inhibitor
- ASG-5ME Tubulin inhibitor
- AVE-9633 Tubulin inhibitor
- Azintuxizumab vedotin Tubulin inhibitor
- Belantamab mafodotin Tubulin inhibitor
- BIIB-015 Tubulin inhibitor
- Bivatuzumab mertansine Tubulin inhibitor
- BMS-275183 Tubulin stabiliser
- Brentuximab vedotin Tubulin inhibitor
- Cabazitaxel Tubulin inhibitor
- Cantuzumab mertansine Tubulin inhibitor
- Cantuzumab ravtansine Tubulin inhibitor
- Colchicine Tubulin inhibitor
- Coltuximab ravtansine Tubulin inhibitor
- Crolibulin Tubulin inhibitor