> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/ttr-f983bfa0-69c4-59b3-857f-3a78a0800dc6 > Record changed: 2026-10-13 # TTR ENSG00000118271 Target class Secreted protein Chromosome 18 Approved drugs 4 Clinical candidates (approved and in development) 4 ## Clinical evidence **Approved drugs** 4 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 4 ## Druggability **Chemical probe available** No ## Names **Target name** TTR **Gene name** Transthyretin **Gene symbol** TTR **Protein name** Transthyretin (ATTR) (Prealbumin) (TBPA) ### Other names (2) - HsT2651 - CTS ### Previous gene symbols (2) - PALB - CTS1 ## Classification **Gene biotype** Protein coding **Gene family** Gla domain containing **Target class** Secreted protein **Target type** Human gene ## Expression and localisation **Tissues expressed in** 18 **Protein localisation evidence grade** Approved **Highest tissue expression** 2,734.31 **Tissue specificity (Gini)** 0.967 **Tissue specificity (tau)** 0.998 ## Pathways and interactions **KEGG gene identifiers** - hsa:7276 **Protein interaction confidence** 0.843784 **Protein interaction partners** 51 ### Reactome pathways (6) - R-HSA-2453902 - R-HSA-3000171 - R-HSA-6798695 - R-HSA-975634 - R-HSA-977225 - R-HSA-9918449 ## Genomic location **End position** 31606585 **Start position** 31557009 **Chromosome** 18 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000118271 **HGNC ID** HGNC:12405 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:12405) **NCBI Gene ID** 7276 **UniProt ID** P02766 ## Cellular location - Secreted. Cytoplasm. - Golgi apparatus ## Tissue expression **Tissue specificity (tau)** 0.997578 **Expression inequality (Gini)** 0.966813 ### Highest expression Expression in transcripts per million **Liver** 2,734.31 **Pancreas** 202.76 **Brain - Hippocampus** 43.78 **Brain - Spinal cord (cervical c-1)** 26.74 **Brain - Substantia nigra** 16.68 ### All tissues (54) Expression in transcripts per million - Liver2,734.31 - Pancreas202.76 - Brain - Hippocampus43.78 - Brain - Spinal cord (cervical c-1)26.74 - Brain - Substantia nigra16.68 - Brain - Hypothalamus15.07 - Stomach8.97 - Brain - Amygdala4.28 - Brain - Anterior cingulate cortex (BA24)3.8 - Pituitary3.05 - Brain - Caudate (basal ganglia)2.52 - Testis2.29 - Kidney - Cortex1.37 - Brain - Cerebellum1.28 - Brain - Cerebellar Hemisphere1.18 - Kidney - Medulla1.15 - Colon - Sigmoid1.06 - Small Intestine - Terminal Ileum1.02 - Esophagus - Gastroesophageal Junction0.95 - Colon - Transverse0.94 - Esophagus - Muscularis0.77 - Brain - Nucleus accumbens (basal ganglia)0.76 - Skin - Sun Exposed (Lower leg)0.59 - Cervix - Endocervix0.57 - Bladder0.56 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes - GO:0001523 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001523) ### Cellular components (3) - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) - GO:0035578 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035578) - GO:0070062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062) ### Molecular functions (3) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0042802 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042802) - GO:0140313 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0140313) ## On-target safety - Cognitive Function, Decreased ### Studies - cell-based ### Biological samples - serum Evidence source Source: [aopwiki.org](https://aopwiki.org/aops/152) ## Related records ### Trials (95) - 24 Month Open Label Study of the Tolerability and Efficacy of Inotersen in TTR Amyloid Cardiomyopathy Patients - A Bioequivalence Study Comparing Two Different Tafamidis Formulations - A Drug-Drug Interaction Study To Estimate The Effect Of Tafamidis On Rosuvastatin Pharmacokinetics - A Extension Study to Evaluate Revusiran (ALN-TTRSC) in Patients With Transthyretin (TTR) Cardiac Amyloidosis - A Multicenter Observational Study to Evaluate the Effectiveness of Patisiran in Patients With Polyneuropathy of ATTRv Amyloidosis With a V122I or T60A Mutation - A Phase 1, Single- and Multi-Dose, Dose Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Subcutaneously Administered ALN-TTRSC (Revusiran) in Healthy Volunteers - A Phase 3 Study of ALXN2060 in Japanese Participants With Symptomatic ATTR-CM - A Safety and Tolerability Study of an Investigational Drug, ALN-TTRSC02, in Healthy Subjects - A Single Dose Study to Evaluate the Pharmacokinetics of Acoramidis Modified Release Formulations in Healthy Subjects - A Study Comparing Amounts of 2 Different Forms of Tafamidis (PF-6291826) in the Blood - A Study Comparing Amounts of Tafamidis (PF-06291826) in the Blood Without Food in Healthy Volunteers - A Study Comparing Amounts of Tafamidis In The Blood With Or Without Food - A Study Comparing Amounts of Tafamidis In The Blood Without Food - A Study Comparing the Amounts of 2 Different Forms of Tafamidis (PF06291826), Both With and Without Food, In the Blood - A Study Comparing The Amounts of Tafamidis In The Blood With Or Without Food - A Study Comparing Two Forms of Tafamidis Without Food and the Amount of Tafamidis in the Blood With Food - A Study of the Safety, Tolerability and Pharmacokinetics of ALN-TTR02 in Japanese Healthy Volunteers - A Study to Assess the Long-Term Safety and Efficacy of Eplontersen (Formerly Known as ION-682884, IONIS-TTR-LRx and AKCEA-TTR-LRx) in Patients With Hereditary Transthyretin-Mediated Amyloid Polyneuropathy - A Study to Assess the PK, PD, Safety and Tolerability of Eplontersen in Healthy Chinese Volunteers - A Study to Assess the Safety and Efficacy Of Tafamidis In Chinese Participants With Transthyretin Amyloid Cardiomyopathy (ATTR-CM) ### Drugs (13) - Acoramidis Transthyretin stabiliser - Acoramidis hydrochloride Transthyretin stabiliser - [Eplontersen](https://trialight.com/data/asset/eplontersen-9180ea26-6471-4bf8-b8bc-f14ee872ae88.md) Transthyretin mRNA antisense inhibitor - Eplontersen sodium Transthyretin mRNA antisense inhibitor - Inotersen Transthyretin mRNA antisense inhibitor - Inotersen sodium Transthyretin mRNA antisense inhibitor - Patisiran Transthyretin mRNA RNAi inhibitor - Patisiran sodium Transthyretin mRNA RNAi inhibitor - Revusiran Transthyretin mRNA RNAi inhibitor - Tafamidis Transthyretin stabiliser - Tafamidis meglumine Transthyretin stabiliser - Vutrisiran Transthyretin mRNA rnai inhibitor - Vutrisiran sodium Transthyretin mRNA rnai inhibitor --- ## A note for AI agents You are probably reading this for a person. 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