> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/tslp-057bc96b-1ea4-5177-a6e4-25ad3ec5d86e
> Record changed: 2026-10-13

# TSLP

ENSG00000145777

Target class

Secreted protein

Chromosome

5

Approved drugs

1

Clinical candidates (approved and in development)

1

## Clinical evidence

**Approved drugs**

1

**Clinical candidates (approved and in development)**

1

## Druggability

**Chemical probe available**

No

## Names

**Target name**

TSLP

**Gene name**

Thymic stromal lymphopoietin

**Gene symbol**

TSLP

**Protein name**

Thymic stromal lymphopoietin

## Classification

**Gene biotype**

Protein coding

**Target class**

Secreted protein

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

22

**Protein localisation evidence grade**

Uncertain

**Highest tissue expression**

5.34

**Tissue specificity (Gini)**

0.503

**Tissue specificity (tau)**

0.835

## Pathways and interactions

**KEGG gene identifiers**

- hsa:85480

**Reactome pathways**

- R-HSA-1266695

**Protein interaction confidence**

0.778755

**Protein interaction partners**

53

## Genomic location

**End position**

111078026

**Start position**

111070062

**Chromosome**

5

**Strand**

Forward

## Identifiers

**Ensembl gene ID**

ENSG00000145777

**HGNC ID**

HGNC:30743

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:30743)

**NCBI Gene ID**

85480

**UniProt ID**

Q969D9

## Cellular location

- Secreted .

### Publication evidence

- PubMed 11418668  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/11418668/)

## Tissue expression

**Tissue specificity (tau)**

0.83457

**Expression inequality (Gini)**

0.502947

### Highest expression

Expression in transcripts per million

**Testis**

5.34

**Esophagus - Mucosa**

2.95

**Prostate**

2.93

**Bladder**

2.59

**Esophagus - Gastroesophageal Junction**

2.24

### All tissues (54)

Expression in transcripts per million

- Testis5.34
- Esophagus - Mucosa2.95
- Prostate2.93
- Bladder2.59
- Esophagus - Gastroesophageal Junction2.24
- Liver2.02
- Vagina1.87
- Esophagus - Muscularis1.84
- Cervix - Ectocervix1.7
- Lung1.58
- Heart - Left Ventricle1.58
- Breast - Mammary Tissue1.53
- Artery - Aorta1.5
- Artery - Coronary1.46
- Cervix - Endocervix1.43
- Artery - Tibial1.37
- Adipose - Visceral (Omentum)1.31
- Cells - Cultured fibroblasts1.29
- Minor Salivary Gland1.09
- Colon - Sigmoid1.08
- Adipose - Subcutaneous1.05
- Heart - Atrial Appendage1.04
- Kidney - Medulla0.92
- Uterus0.85
- Colon - Transverse0.79

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (16)

- GO:0001961  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001961)
- GO:0007259  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007259)
- GO:0008284  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008284)
- GO:0019221  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019221)
- GO:0032722  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032722)
- GO:0032733  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032733)
- GO:0032736  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032736)
- GO:0032754  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032754)
- GO:0032755  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032755)
- GO:0033005  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0033005)
- GO:0038111  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038111)
- GO:0043066  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043066)
- GO:0050729  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050729)
- GO:0071654  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071654)
- GO:0071657  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071657)
- GO:1904894  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1904894)

### Cellular components

- GO:0005576  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576)

### Molecular functions (2)

- GO:0005125  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005125)
- GO:0005139  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005139)

## Related records

### Trials (73)

- [A Comparative Phase 1 Study to Evaluate the Pharmacokinetic and Safety of QL2302 vs. Tezspire® in Healthy Subjects](https://trialight.com/data/trial/a-comparative-phase-1-study-to-evaluate-the-pharmacokinetic-20cf5c1a-8bb1-42d7-8f40-33c7d8eea1ae.md)
- A Dose Ranging Placebo-Controlled Double-Blind Study to Evaluate the Safety and Efficacy of Tezepelumab in Atopic Dermatitis
- A Phase 1 Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Immunogenicity of MEDI9929 After Single Administration in Healthy Male Japanese Subjects
- A Phase Ⅲ Study of Hemay022 in Combination With AI In Advanced Breast Cancer
- A Study to Evaluate the Pharmacokinetics of MEDI9929 (AMG 157) in Adolescents With Mild to Moderate Asthma
- A Study to Evaluate the Pharmacokinetics of Tezepelumab After Being Delivered by an Accessorized Pre Filled Syringe or Autoinjector Compared With Vial and Syringe in Healthy Adult Subjects
- A Study to Investigate Changes in Symptoms in Adult Participants With Chronic Rhinosinusitis With Nasal Polyposis Initiating Treatment With Tezepelumab
- A Study to Investigate NPS and Symptoms in Chinese Adult Participants With CRSwNP Initiating Treatment With Tezepelumab
- A Study to Investigate Pharmacokinetics, Pharmacodynamics, and Safety of Subcutaneous Anifrolumab in Pediatric Participants 5 to < 18 Years of Age With Systemic Lupus Erythematosus
- A Study to Investigate the Efficacy and Safety of Tezepelumab Compared With Placebo in Children 5 to < 12 Years Old With Severe Asthma
- A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe COPD (D5241C00006)
- A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe COPD (D5241C00007)
- Adjuvant AI Combined With Zoladex
- Anti-TSLP (AMG 157) Plus Antigen-Specific Immunotherapy for Induction of Tolerance in Individuals With Cat Allergy
- Apatinib With CDK4/6 Inhibitor and Endocrine Therapy in HR+/ HER2- Advanced Breast Cancer
- Aztreonam for Inhalation (AI) in Patients With Cystic Fibrosis & P. Aeruginosa Infection
- Clinical Study of Adjuvant Therapy on Post-menopausal Women With Breast Cancer Under the Guidance of the Results of Preoperative Endocrinotherapy
- Compare the Efficacy and Safety of QL2302 Versus Tezspire® in Severe Asthma
- Comparison of Clinical Efficacy Between Letrozole + Ribociclib and Fulvestrant + Letrozole + Ribociclib in Hormone Receptor Positive, HER2 Negative Metastatic Breast Cancer
- Dimethyldiguanide Combined With Aromatase Inhibitor (AI) in Metastatic Breast Cancer

### Drugs (1)

- [Tezepelumab](https://trialight.com/data/asset/tezepelumab-8dc36556-e99a-4122-9017-127f366a520e.md) Thymic stromal lymphopoietin inhibitor

---

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