> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/trpv4-37011d08-a370-576a-af19-762971348964 > Record changed: 2026-11-04 # TRPV4 ENSG00000111199 Target class Ion channel Chromosome 12 Approved drugs 2 Clinical candidates (approved and in development) 3 ## Clinical evidence **Approved drugs** 2 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 3 ## Druggability **Chemical probe available** Yes ## Names **Target name** TRPV4 **Gene name** Transient receptor potential cation channel subfamily V member 4 **Gene symbol** TRPV4 **Protein name** Transient receptor potential cation channel subfamily V member 4 (TrpV4) (Osm-9-like TRP channel 4) (OTRPC4) (Transient receptor potential protein 12) (TRP12) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC) ### Other names (6) - OTRPC4 - TRP12 - VROAC - VRL-2 - VR-OAC - CMT2C ## Classification **Gene biotype** Protein coding **Gene family** Transient receptor potential cation channels|Ankyrin repeat domain containing **Target class** Ion channel **Target type** Human gene ## Expression and localisation **Tissues expressed in** 25 **Highest tissue expression** 28.02 **Tissue specificity (Gini)** 0.704 **Tissue specificity (tau)** 0.914 ## Pathways and interactions **KEGG gene identifiers** - hsa:59341 **Protein interaction confidence** 0.836929 **Protein interaction partners** 42 ### Reactome pathways (2) - R-HSA-3295583 - R-HSA-9856530 ## Genomic location **End position** 109833406 **Start position** 109783087 **Chromosome** 12 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000111199 **HGNC ID** HGNC:18083 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:18083) **NCBI Gene ID** 59341 **UniProt ID** Q9HBA0 ## Cellular location - Cell membrane . Apical cell membrane - Multi-pass membrane protein . Cell junction, adherens junction . Cell projection, cilium . Note=Assembly of the putative homotetramer occurs primarily in the endoplasmic reticulum (PubMed:16293632, PubMed:20037587, PubMed:20037588). Localization to the cell membrane is inhibited by WNK kinases (WNK1, WNK2, WNK3 or WNK4) in a kinase-independent mechanism (PubMed:16403833). . - SUBCELLULAR LOCATION: \[Isoform 1\]: Cell membrane . - SUBCELLULAR LOCATION: \[Isoform 5\]: Cell membrane . - SUBCELLULAR LOCATION: \[Isoform 2\]: Endoplasmic reticulum . - SUBCELLULAR LOCATION: \[Isoform 4\]: Endoplasmic reticulum . - SUBCELLULAR LOCATION: \[Isoform 6\]: Endoplasmic reticulum . ### Publication evidence (9) - PubMed 16403833 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/16403833/) - PubMed 29899501 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/29899501/) - PubMed 18695040 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/18695040/) - PubMed 18826956 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/18826956/) - PubMed 16293632 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/16293632/) - PubMed 20037587 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/20037587/) - PubMed 20037588 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/20037588/) - PubMed 21964574 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/21964574/) - PubMed 25256292 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/25256292/) ## Tissue expression **Tissue specificity (tau)** 0.914219 **Expression inequality (Gini)** 0.703927 ### Highest expression Expression in transcripts per million **Minor Salivary Gland** 28.02 **Esophagus - Mucosa** 13.39 **Kidney - Cortex** 13.34 **Prostate** 12.79 **Skin - Sun Exposed (Lower leg)** 11.96 ### All tissues (54) Expression in transcripts per million - Minor Salivary Gland28.02 - Esophagus - Mucosa13.39 - Kidney - Cortex13.34 - Prostate12.79 - Skin - Sun Exposed (Lower leg)11.96 - Skin - Not Sun Exposed (Suprapubic)11.19 - Kidney - Medulla11.14 - Liver4.76 - Spleen4.5 - Pituitary4.08 - Vagina3.61 - Lung3.08 - Pancreas2.76 - Cells - Cultured fibroblasts2.69 - Breast - Mammary Tissue2.27 - Thyroid2.05 - Testis1.91 - Artery - Aorta1.84 - Bladder1.6 - Artery - Coronary1.6 - Nerve - Tibial1.55 - Adipose - Visceral (Omentum)1.42 - Cervix - Endocervix1.27 - Adipose - Subcutaneous1.12 - Adrenal Gland1.1 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (13) - GO:0006816 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006816) - GO:0006874 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006874) - GO:0006884 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006884) - GO:0007204 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007204) - GO:0007231 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007231) - GO:0009612 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009612) - GO:0043117 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043117) - GO:0050891 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050891) - GO:0060351 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060351) - GO:0070588 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070588) - GO:0071476 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071476) - GO:0097497 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097497) - GO:1902656 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1902656) ### Cellular components (3) - GO:0005783 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005783) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0016324 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016324) ### Molecular functions (7) - GO:0005261 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005261) - GO:0005262 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005262) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0005516 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005516) - GO:0015275 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015275) - GO:0019901 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019901) - GO:0042802 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042802) ## Related records ### Trials (2,786) - "Curcumin" in Combination With Chemotherapy in Advanced Breast Cancer - "Volatile Anesthetic Protection Of Renal Transplants: VAPOR-1-trail - 12-O-Tetradecanoylphorbol-13-acetate in Treating Patients With Hematologic Cancer or Bone Marrow Disorder - 18-Month Study of Memory Effects of Curcumin - 4-methylpyrazole and Acetaminophen Metabolism - A "Window Trial" on Curcumin for Invasive Breast Cancer Primary Tumors - A 12-Week Efficacy Study of Paracetamol 1000mg Sustained-release Tablets in Patients With Osteoarthritis - A 2×2 Factorial Randomized Controlled Trial for ERCP - A 56-Week Extension to a Clinical Study to Assess the Efficacy and Safety of Vildagliptin Compared to Placebo in Drug Naive Patients With Type 2 Diabetes and Mild Hyperglycemia - A Bioequivalence Study Between Two Brands of Medications to Treat Cough & Cold Symptoms - A Bioequivalence Study of a New Paracetamol Oral Suspension 24mg/ml Compared to the Marketed Paracetamol Oral Suspension (Panadol Baby and Infant 24mg/ml) in Healthy Adult Subjects - A Clinical Study Evaluating Sedation of Intravenous Administration of HSK3486 in ICU Patients Undergoing Long-Term Mechanical Ventilation - A Clinical Study of Remimazolam Tosilate Compared to Propofol for General Anesthesia During Elective Surgery - A Clinical Study of Remimazolam Tosilate in Patients Undergoing Bronchoscopy - A Clinical Study to Assess the Effect of Vildagliptin on Beta Cell Function in Drug Naive Patients With Type 2 Diabetes - A Clinical Study to Assess the Effect of Vildagliptin on Postprandial Lipid Parameters in Patients With Type 2 Diabetes - A Clinical Study to Assess the Efficacy and Safety of Three Doses of Vildagliptin in Patients With Type 2 Diabetes - A Clinical Study to Assess the Efficacy and Safety of Vildagliptin in Patients With Type 2 Diabetes - A Clinical Trial Evaluating the Efficacy and Safety of HSK3486 Injectable Emulsion in Elective Surgery Patients - [A Clinical Trial of GRT7040 in Adults With Acute Pain Following Bunionectomy](https://trialight.com/data/trial/a-clinical-trial-of-grt7040-in-adults-with-acute-pain-3b9db717-4c06-4408-bf37-ba823ee45a4f.md) ### Drugs (9) - [Acetaminophen](https://trialight.com/data/asset/acetaminophen-04ea33a5-49ee-4a1b-ad16-54627012140e.md) - Butamben Transient receptor potential cation channel subfamily V member 4 inhibitor - Butamben picrate Transient receptor potential cation channel subfamily V member 4 inhibitor - Curcumin - GSK2798745 Transient receptor potential cation channel subfamily V member 4 antagonist - Phorbol myristate acetate - Propofol - Puerarin - Vildagliptin --- ## A note for AI agents You are probably reading this for a person. 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