> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/trpv2-0b9b19ad-a0c9-5902-b7ee-c9fd4ba76ca2 > Record changed: 2026-11-04 # TRPV2 ENSG00000187688 Target class Ion channel Chromosome 17 ## Druggability **Chemical probe available** No ## Names **Target name** TRPV2 **Gene name** Transient receptor potential cation channel subfamily V member 2 **Gene symbol** TRPV2 **Protein name** Transient receptor potential cation channel subfamily V member 2 (TrpV2) (Osm-9-like TRP channel 2) (OTRPC2) (Vanilloid receptor-like protein 1) (VRL-1) ### Other names (3) - VRL - VRL-1 - VRL1 ## Classification **Gene biotype** Protein coding **Gene family** Transient receptor potential cation channels|Ankyrin repeat domain containing **Target class** Ion channel **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Protein localisation evidence grade** Supported **Highest tissue expression** 83.47 **Tissue specificity (Gini)** 0.505 **Tissue specificity (tau)** 0.85 ## Pathways and interactions **KEGG gene identifiers** - hsa:51393 **Reactome pathways** - R-HSA-3295583 **Protein interaction confidence** 0.835133 **Protein interaction partners** 15 ## Genomic location **End position** 16437003 **Start position** 16415571 **Chromosome** 17 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000187688 **HGNC ID** HGNC:18082 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:18082) **NCBI Gene ID** 51393 **UniProt ID** Q9Y5S1 ## Cellular location - Cell membrane - Multi-pass membrane protein . Cytoplasm . Melanosome . Note=Translocates from the cytoplasm to the plasma membrane upon ligand stimulation (By similarity). Expressed in melanosomes during melanosome maturation from stage I to stage IV. . - Plasma membrane ### Publication evidence - PubMed 17081065 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/17081065/) ## Tissue expression **Tissue specificity (tau)** 0.849904 **Expression inequality (Gini)** 0.505436 ### Highest expression Expression in transcripts per million **Cells - EBV-transformed lymphocytes** 83.47 **Lung** 61.57 **Spleen** 43.16 **Artery - Coronary** 36.19 **Artery - Tibial** 33.82 ### All tissues (54) Expression in transcripts per million - Cells - EBV-transformed lymphocytes83.47 - Lung61.57 - Spleen43.16 - Artery - Coronary36.19 - Artery - Tibial33.82 - Whole Blood31.56 - Cells - Cultured fibroblasts29.84 - Adipose - Visceral (Omentum)25.55 - Adrenal Gland24.94 - Adipose - Subcutaneous23.97 - Ovary17.57 - Small Intestine - Terminal Ileum17.28 - Bladder16.35 - Breast - Mammary Tissue15.89 - Nerve - Tibial15.53 - Uterus15.25 - Fallopian Tube15.24 - Cervix - Endocervix15.09 - Cervix - Ectocervix14.82 - Artery - Aorta14.34 - Vagina13.98 - Thyroid13.54 - Esophagus - Gastroesophageal Junction12.74 - Esophagus - Muscularis12.65 - Prostate10.72 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (3) - GO:0007600 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007600) - GO:0009266 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009266) - GO:0070588 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070588) ### Cellular components - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) ### Molecular functions (5) - GO:0005216 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005216) - GO:0005261 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005261) - GO:0005262 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005262) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0015075 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015075) ## Related records ### Trials (440) - 5-Way Crossover Study to Compare the Safety, Tolerability and Pharmacokinetics of New Oral Cannabinoid Formulations Administered as Single Doses, With Buccal Sativex®, in Healthy Volunteers - A Clinical Study of Tranilast in the Treatment of Cryopyrin-Associated Periodic Syndrome (CAPS) - A Clinical Study of Tranilast in the Treatment of Mucinoses - A Clinical Study of Tranilast in the Treatment of Sarcoidosis - A Clinical Study of Tranilast in the Treatment of Scleredema Diabeticorum - A Clinical Trial of a Hemp-Derived, High Cannabidiol Product for Anxiety in Glioblastoma Patients - A Clinical Trial on the Antipsychotic Properties of Cannabidiol - A Crossover Pilot Study of the Effect of Amiloride on Proteinuria - A Double-Blind Trial to Evaluate Efficacy and Safety of Cannabidiol as an add-on Therapy for Treatment in Refractory Epilepsy - A Double-Blinded Study on Rapid and Sustained Pain Relief Topical Cannabidiol for Plantar Fasciitis - A Four-week Clinical Trial Investigating Efficacy and Safety of Cannabidiol As a Treatment for Acutely Ill Schizophrenic Patients - A Long-term Safety Study of Cannabidiol Oral Solution (GWP42003-P, CBD-OS) in Patients With Rett Syndrome - A Manufacturing Transfer Study Comparing the Bioequivalence of a Single Oral Dose of Claritin-D 12-Hour Extended Release Tablet From 2 Different Manufactuers Under Fed Conditions in Healthy Adult Subjects - A Manufacturing Transfer Study Comparing the Bioequivalence of a Single Oral Dose of Claritin-D 12-Hour Extended Release Tablet From 2 Different Manufacturers Under Fasted Conditions in Healthy Adult Subjects - A New Application of Amiloride in the Treatment of Patient With Chronic Kidney Disease In Reducing Urinary PROtein - A Pharmacokinetic Study to Compare CBD-NE to Epidyolex in Healthy Adult Volunteers Under Both Fed and Fasted Conditions - A Phase 2a Study to Evaluate the Safety and Efficacy of Cannabidiol Only as Maintenance Therapy and Steroid Sparing in Patients With Stable Autoimmune Hepatitis - A Phase I Study to Assess the Safety and Tolerability of Topical CRx-197 Formulations in Healthy Volunteers - A Pilot Study of GWP42003 in the Symptomatic Treatment of Ulcerative Colitis (GWID10160) - A Prospective Study to Investigate Safety and Tolerability of Shorter Infusion of Fabrazyme ### Drugs (5) - Amiloride - [Cannabidiol](https://trialight.com/data/asset/cannabidiol-e1ac1a9a-1111-460c-8a8f-5216571adce8.md) - Loratadine - SK&F-96365 - Tranilast --- ## A note for AI agents You are probably reading this for a person. 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