> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/trpv1-ca64e282-0693-5882-a5bc-8b93d8310d3a > Record changed: 2026-10-13 # TRPV1 ENSG00000196689 Target class Ion channel Chromosome 17 Approved drugs 2 Clinical candidates (approved and in development) 18 ## Clinical evidence **Approved drugs** 2 **Clinical candidates (approved and in development)** 18 ## Druggability **Chemical probe available** Yes ## Names **Target name** TRPV1 **Gene name** Transient receptor potential cation channel subfamily V member 1 **Gene symbol** TRPV1 **Previous gene symbols** - VR1 **Protein name** Transient receptor potential cation channel subfamily V member 1 (TrpV1) (Capsaicin receptor) (Osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1) ## Classification **Gene biotype** Protein coding **Gene family** Transient receptor potential cation channels|Ankyrin repeat domain containing **Target class** Ion channel **Target type** Human gene ## Expression and localisation **Tissues expressed in** 53 **Highest tissue expression** 29.62 **Tissue specificity (Gini)** 0.299 **Tissue specificity (tau)** 0.703 ## Pathways and interactions **KEGG gene identifiers** - hsa:7442 **Reactome pathways** - R-HSA-3295583 **Protein interaction confidence** 0.8426 **Protein interaction partners** 50 ## Genomic location **End position** 3609411 **Start position** 3565444 **Chromosome** 17 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000196689 **HGNC ID** HGNC:12716 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:12716) **NCBI Gene ID** 7442 **UniProt ID** Q8NER1 ## Cellular location - Postsynaptic cell membrane - Multi-pass membrane protein . Cell projection, dendritic spine membrane - Multi-pass membrane protein . Cell membrane - Multi-pass membrane protein . Note=Mostly, but not exclusively expressed in postsynaptic dendritic spines. . ### Publication evidence (4) - PubMed 37117175 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/37117175/) - PubMed 11050376 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/11050376/) - PubMed 11243859 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/11243859/) - PubMed 12077606 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/12077606/) ## Tissue expression **Tissue specificity (tau)** 0.702712 **Expression inequality (Gini)** 0.299013 ### Highest expression Expression in transcripts per million **Nerve - Tibial** 29.62 **Brain - Cerebellum** 23.6 **Brain - Cerebellar Hemisphere** 22.9 **Cervix - Endocervix** 21.16 **Ovary** 20.81 ### All tissues (54) Expression in transcripts per million - Nerve - Tibial29.62 - Brain - Cerebellum23.6 - Brain - Cerebellar Hemisphere22.9 - Cervix - Endocervix21.16 - Ovary20.81 - Cervix - Ectocervix14.5 - Fallopian Tube14.19 - Liver14.02 - Vagina13.21 - Small Intestine - Terminal Ileum12.91 - Artery - Tibial11.37 - Testis11.25 - Uterus11.06 - Prostate10.93 - Pituitary10.86 - Breast - Mammary Tissue10.71 - Adipose - Subcutaneous10.45 - Thyroid10.2 - Skin - Sun Exposed (Lower leg)9.22 - Bladder8.99 - Kidney - Medulla8.6 - Skin - Not Sun Exposed (Suprapubic)8.44 - Brain - Spinal cord (cervical c-1)8.25 - Colon - Transverse8.16 - Kidney - Cortex8.12 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (8) - GO:0007166 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007166) - GO:0007635 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007635) - GO:0034605 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034605) - GO:0050955 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050955) - GO:0070588 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070588) - GO:0071468 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071468) - GO:0098703 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0098703) - GO:1901594 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1901594) ### Cellular components (2) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0016020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020) ### Molecular functions (5) - GO:0005230 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005230) - GO:0005245 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005245) - GO:0005262 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005262) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0051219 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051219) ## Related records ### Trials (2,173) - "A Prospective Study of the Efficacy of Intracameral Dexamethasone (Dexycu™) Compared to Standard of Care Treatment for Post-Cataract Surgical Pain and Anterior Chamber Inflammation" - "Postoperative Pain Following Laser-Assisted Root Canal Treatment: A Randomized Clinical Trial" - 0.075% Capsaicin Lotion for the Treatment of Painful Diabetic Neuropathy - 4-methylpyrazole and Acetaminophen Metabolism - 5 mg Glipizide/500 mg Metformin Hydrochloride Tablets, Fasting - 5 mg Glipizide/500 mg Metformin Hydrochloride Tablets, Non-Fasting - A 12-Week Efficacy Study of Paracetamol 1000mg Sustained-release Tablets in Patients With Osteoarthritis - A 3-Month Clinical Trial to Assess the Safety and Efficacy of the OZURDEX® Intraocular Implant in Patients With Diabetes Mellitus - A 5-treatment, Study in Healthy Volunteers to Assess The Safety, Tolerability, and Pharmacokinetics of Four Controlled Release (CR) Pregabalin Tablet Formulations and the Immediate Release (IR) Formulation Administered Fasted - A Bioequivalence (BE) Study Comparing The Commericializable And Clinical Formulations Of PF-00299804 - A Bioequivalence Study Between Two Brands of Medications to Treat Cough & Cold Symptoms - A Bioequivalence Study of a New Paracetamol Oral Suspension 24mg/ml Compared to the Marketed Paracetamol Oral Suspension (Panadol Baby and Infant 24mg/ml) in Healthy Adult Subjects - A Bioequivalence Study of CT-L01 Compared to Co-administration (ALO 12.5 mg and MET XR 500 mg) in Healthy Volunteers - A Bioequivalence Study of the Fixed Dose Combination Tablets of Canagliflozin and Metformin Extended Release (XR) With Respect to the Individual Components - A Bioequivalence Study of the Fixed Dose Combination Tablets of Canagliflozin and Metformin Extended Release (XR) With Respect to the Individual Components - A Bioequivalence Study of the Fixed Dose Combination Tablets of Canagliflozin and Metformin Extended Release (XR) With Respect to the Individual Components in Healthy Fed Participants - A Bioequivalence Study of the Fixed Dose Combination Tablets of Canagliflozin and Metformin Extended Release (XR) With Respect to the Individual Components in Healthy Fed Participants - A Bioequivalence Study of the Fixed Dose Combinations of Saxagliptin/Metformin XR Relative to Co-Administration - A Clinical Pharmacology Trial of Brexpiprazole Once-weekly (QW) Formulation Administered as Single and Multiple Oral Doses - A Clinical Study Intended To Compare Treatment With Voriconazole To Treatment With Amphotericin Followed By Fluconazole In Patients With Candidemia, A Serious Fungus Infection Of The Blood. ### Drugs (19) - ABT-102 Vanilloid receptor antagonist - [Acetaminophen](https://trialight.com/data/asset/acetaminophen-04ea33a5-49ee-4a1b-ad16-54627012140e.md) Vanilloid receptor opener - AMG-517 Vanilloid receptor antagonist - AZD1386 Vanilloid receptor antagonist - Capsaicin Vanilloid receptor opener - DWP05195 Vanilloid receptor antagonist - GRC-6211 Vanilloid receptor antagonist - JTS-653 Vanilloid receptor antagonist - Mavatrep Vanilloid receptor antagonist - MR-1817 Vanilloid receptor antagonist - NGD-8243 Vanilloid receptor antagonist - PAC-14028 Vanilloid receptor antagonist - PHE377 Vanilloid receptor antagonist - Resiniferatoxin Vanilloid receptor agonist - SAF312 Vanilloid receptor inhibitor - SB-705498 Vanilloid receptor antagonist - Tivanisiran Vanilloid receptor mRNA antisense inhibitor - XEN-D0501 Vanilloid receptor antagonist - Zucapsaicin Vanilloid receptor agonist --- ## A note for AI agents You are probably reading this for a person. 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