> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/trpm8-2cea961c-2883-5b64-af98-c8a3e6ca6f27 > Record changed: 2026-10-13 # TRPM8 ENSG00000144481 Target class Ion channel Chromosome 2 Approved drugs 1 Clinical candidates (approved and in development) 3 ## Clinical evidence **Approved drugs** 1 **Clinical candidates (approved and in development)** 3 ## Druggability **Chemical probe available** Yes ## Names **Target name** TRPM8 **Gene name** Transient receptor potential cation channel subfamily M member 8 **Gene symbol** TRPM8 **Protein name** Transient receptor potential cation channel subfamily M member 8 (Long transient receptor potential channel 6) (LTrpC-6) (LTrpC6) (Transient receptor potential p8) (Trp-p8) ## Classification **Gene biotype** Protein coding **Gene family** Transient receptor potential cation channels **Target class** Ion channel **Target type** Human gene ## Expression and localisation **Tissues expressed in** 2 **Highest tissue expression** 14.1 **Tissue specificity (Gini)** 0.944 **Tissue specificity (tau)** 0.987 ## Pathways and interactions **KEGG gene identifiers** - hsa:79054 **Reactome pathways** - R-HSA-3295583 **Protein interaction confidence** 0.850111 **Protein interaction partners** 18 ## Genomic location **End position** 234019522 **Start position** 233917373 **Chromosome** 2 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000144481 **HGNC ID** HGNC:17961 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:17961) **NCBI Gene ID** 79054 **UniProt ID** Q7Z2W7 ## Cellular location - Cell membrane - Multi-pass membrane protein . Membrane raft . Endoplasmic reticulum membrane . Note=Lipid raft association modulates TRPM8 channel activity (By similarity). Located in the endoplasmic reticulum in prostate cancer cells (PubMed:11325849, PubMed:16174775). . ### Publication evidence (3) - PubMed 16174775 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/16174775/) - PubMed 37857704 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/37857704/) - PubMed 11325849 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/11325849/) ## Tissue expression **Tissue specificity (tau)** 0.987127 **Expression inequality (Gini)** 0.944351 ### Highest expression Expression in transcripts per million **Prostate** 14.1 **Liver** 7.65 **Testis** 0.72 **Pituitary** 0.27 **Brain - Hypothalamus** 0.11 ### All tissues (54) Expression in transcripts per million - Prostate14.1 - Liver7.65 - Testis0.72 - Pituitary0.27 - Brain - Hypothalamus0.11 - Brain - Caudate (basal ganglia)0.08 - Brain - Putamen (basal ganglia)0.07 - Brain - Cerebellum0.06 - Brain - Cerebellar Hemisphere0.05 - Brain - Substantia nigra0.04 - Brain - Nucleus accumbens (basal ganglia)0.04 - Kidney - Cortex0.04 - Spleen0.04 - Skin - Sun Exposed (Lower leg)0.03 - Brain - Frontal Cortex (BA9)0.03 - Brain - Spinal cord (cervical c-1)0.03 - Pancreas0.03 - Minor Salivary Gland0.03 - Vagina0.03 - Brain - Anterior cingulate cortex (BA24)0.03 - Cervix - Endocervix0.02 - Brain - Cortex0.02 - Brain - Amygdala0.02 - Cervix - Ectocervix0.02 - Breast - Mammary Tissue0.01 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes - GO:0070588 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070588) ### Cellular components (2) - GO:0005789 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005789) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) ### Molecular functions (2) - GO:0005262 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005262) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## Related records ### Trials (49) - A Local Clinical Study for the Comparative Evaluation of Efficacy and Safety of Angal, Lozenges \[Menthol\] and ANTI-ANGIN® FORMULA, Lozenges, in Treatment of Patients With a Sore Throat - A Long-Term Safety Study of Elismetrep (K-304) in the Acute Treatment of Migraine - A Multicenter Efficacy Study of a Diclofenac+Menthol Gel in Subjects With Ankle Sprain - [A Phase IIb, Randomized, Double-Blind, Placebo-Controlled Study of Elismetrep (K-304) in the Treatment of Migraine](https://trialight.com/data/trial/a-phase-iib-randomized-double-blind-placebo-controlled-study-f155ecb4-2425-4fb5-9275-b0bdc35aebf1.md) - A Safety Study to Investigate the Skin Irritancy Potential of Diclofenac-Menthol Gel - A Safety Study to Investigate the Skin Sensitization Potential of MFC51123 - [A Study to Evaluate the Efficacy and Safety of Elismetrep (K-304) in the Acute Treatment of Migraine](https://trialight.com/data/trial/a-study-to-evaluate-the-efficacy-and-safety-of-elismetrep-k-9b1f8049-5b6c-4601-9c3d-6935b7139193.md) - A Study to Evaluate the Efficacy and Safety of K-285 Compared With Menthol Gel for the Treatment of Delayed Onset Muscle Soreness (DOMS) in the Lower Extremity - A Study to Investigate the Effect of MT-8554 on the Pharmacokinetics of Simvastatin and Rosuvastatin in Healthy Subjects - A Study to Investigate the Pharmacodynamic Effect of Single Doses of MT-8554 in Healthy Subjects - A Study to Investigate the Safety, Tolerability and Pharmacokinetics of MT-8554 in Healthy Subjects - A Study to Investigate the Safety, Tolerability and Pharmacokinetics of Multiple Doses of MT-8554 in Female Subjects Experiencing Vasomotor Symptoms - Analgesic Induces Similar Upper and Lower Body Pain Pressure Threshold Increases - Assess the Efficacy and Safety in Volunteers of DCF100, TIB200 and SPR300 vs. Placebo and Control(s) in a UV Pain Model - Clinical Adhesion Study Between ZTlido 1.8% and Three Over-the-counter External Analgesic Lidocaine-containing Patches - Clinical Study for Comparative Assessment of Efficacy and Safety of Angal S, Topical Spray and ANTI-ANGIN® FORMULA, Topical Metered Spray in Treatment of Patients With Uncomplicated Acute Infectious and Inflammatory Diseases of the Pharynx, Accompanied by a Sore Throat - Comparative Efficacy of the Suppository Versus Guaiacol Suppository Versus Guaifenesin Syrup in Pediatric Patients With Cough Due the Infectious Origin - Comparison of Prescription Lidocaine Patch to Over the Counter Lidocaine Patch and Placebo for Back Pain and Arthritis - Definitive QT Study With MT-8554 - Dose Escalation Study of EC D-3263 HCl in Advanced Solid Tumors ### Drugs (3) - D-3263 Transient receptor potential cation channel subfamily M member 8 agonist - [Elismetrep](https://trialight.com/data/asset/elismetrep-d1d2d3aa-cab3-4b9c-bfc5-9f60e1f4559a.md) Transient receptor potential cation channel subfamily M member 8 inhibitor - Menthol Transient receptor potential cation channel subfamily M member 8 opener --- ## A note for AI agents You are probably reading this for a person. 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