> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/trpm3-4511083f-b234-5312-a137-af4a7c7f8985
> Record changed: 2026-11-04

# TRPM3

ENSG00000083067

Target class

Ion channel

Chromosome

9

## Clinical evidence

**ClinGen gene-disease validity**

Definitive

## Druggability

**Chemical probe available**

No

## Names

**Target name**

TRPM3

**Gene name**

Transient receptor potential cation channel subfamily M member 3

**Gene symbol**

TRPM3

**Protein name**

Transient receptor potential cation channel subfamily M member 3 (Long transient receptor potential channel 3) (LTrpC-3) (LTrpC3) (Melastatin-2) (MLSN2)

### Other names (3)

- KIAA1616
- LTRPC3
- GON-2

## Classification

**Gene biotype**

Protein coding

**Gene family**

Transient receptor potential cation channels|MicroRNA protein coding host genes

**Target class**

Ion channel

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

19

**Protein localisation evidence grade**

Uncertain

**Highest tissue expression**

20

**Tissue specificity (Gini)**

0.737

**Tissue specificity (tau)**

0.93

## Pathways and interactions

**KEGG gene identifiers**

- hsa:80036

**Reactome pathways**

- R-HSA-3295583

**Protein interaction confidence**

0.8058

**Protein interaction partners**

10

## Genomic location

**End position**

71446977

**Start position**

70529060

**Chromosome**

9

**Strand**

Reverse

## Identifiers

**Ensembl gene ID**

ENSG00000083067

**HGNC ID**

HGNC:17992

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:17992)

**NCBI Gene ID**

80036

**UniProt ID**

Q9HCF6

## Cellular location

- Cell membrane
- Multi-pass membrane protein .

### Publication evidence (2)

- PubMed 12672827  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/12672827/)
- PubMed 21278253  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/21278253/)

## Tissue expression

**Tissue specificity (tau)**

0.929821

**Expression inequality (Gini)**

0.737494

### Highest expression

Expression in transcripts per million

**Brain - Cerebellum**

20

**Brain - Cerebellar Hemisphere**

19.85

**Brain - Substantia nigra**

4.92

**Brain - Hypothalamus**

4.08

**Brain - Frontal Cortex (BA9)**

3.32

### All tissues (54)

Expression in transcripts per million

- Brain - Cerebellum20
- Brain - Cerebellar Hemisphere19.85
- Brain - Substantia nigra4.92
- Brain - Hypothalamus4.08
- Brain - Frontal Cortex (BA9)3.32
- Brain - Cortex3.27
- Brain - Amygdala3.12
- Nerve - Tibial2.94
- Pituitary2.91
- Kidney - Cortex2.85
- Brain - Anterior cingulate cortex (BA24)2.73
- Testis2.64
- Kidney - Medulla2.59
- Brain - Caudate (basal ganglia)2.55
- Brain - Nucleus accumbens (basal ganglia)2.4
- Brain - Putamen (basal ganglia)2.1
- Brain - Spinal cord (cervical c-1)1.97
- Brain - Hippocampus1.77
- Ovary1.72
- Artery - Coronary0.68
- Thyroid0.56
- Artery - Aorta0.5
- Cervix - Endocervix0.45
- Adipose - Visceral (Omentum)0.43
- Cervix - Ectocervix0.39

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (2)

- GO:0006812  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006812)
- GO:0070588  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070588)

### Cellular components

- GO:0005886  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886)

### Molecular functions (2)

- GO:0005261  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005261)
- GO:0005262  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005262)

## Related records

### Trials (951)

- "NSAIDs in Acute Achilles Tendinopathy: Effect on Pain Control, Leg Stiffness and Functional Recovery in Athletes"
- "Pecos" B-adrenergic and PPAR-G Stimulation Upregulates Lipid Metabolism in Human Subcutaneous Fat
- "Supracondylar Radial Nerve Block Guided by Ultrasound Versus Hematoma Block for Analgesic Management in Closed Reduction of Distal Radius Fractures"
- "TAKE TIME" Pioglitazone Reverses Defects in Mitochondrial Biogenesis in Patients With T2DM
- 11ß-HSD1 and Metabolic Syndrome
- 30 Week Parallel Group Comparison Study of Linagliptin + Pioglitazone (5+15, 5+30 and 5+45 mg) qd Versus Respective Monotherapies, Followed by a Comparison of 5mg+30mg and 5mg+45mg Versus Respective Monotherapies in Type 2 Diabetes for up to 54 Weeks
- 30-Week Extension to an Initial Combination Study (24 Weeks in Duration) of Sitagliptin With Pioglitazone (0431-064)
- A Bioequivalence Study Using Clinical Endpoint for Diclofenac Sodium Gel 1% in Osteoarthritis Knee"
- A Clinical Trial to Compare Safety and Effectiveness for Relieving Tenderness of 10% Naproxen Gel vs. a 2.32% Diclofenac Diethylamine Gel in the Treatment of Strains and Bruises of the Legs.
- A Clinical Trial to Evaluate the Efficacy, Tolerability, and Safety of a Fixed Dose Combination of Spironolactone, Pioglitazone & Metformin (SPIOMET) in Polycystic Ovary Syndrome (PCOS)
- A Clinical Trial to Prevent the Complications of Insulin Resistance (Including Type-2 Diabetes)
- A Comparative Evaluation of Diclofenac Sodium Transdermal Patch, Oral Diclofenac Sodium With Intramuscular Injections of Diclofenac Sodium in Patients Suffering From Oral Pain
- A Comparison of NSAIDs for Acute, Non-radicular Low Back Pain.
- A Comparison of Two Treatment Strategies in Older Participants With Type 2 Diabetes Mellitus (T2DM)
- A Dose-Range Finding Study in Participants With Type 2 Diabetes (MK-3102-006)
- A Double-blind, Parallel Group, Comparative Study of Coadministration AD-4833 and SYR-322
- A Drug-Drug Interaction Study of the Effects of XL184 (Cabozantinib) on Rosiglitazone in Subjects With Solid Tumors
- A Lifestyle and Combination Medication Therapy Diabetes Prevention Study
- A Methodological Study To Evaluate The Effects of Single Oral Doses Of Pioglitazone 45 mg And Rosiglitazone 8 mg On Sodium Balance In Healthy Male Volunteers
- A Multi-Center, Randomized, Double-Blind, Parallel Group Study To Compare The Efficacy And Tolerability Of Valdecoxib And Diclofenac In Patients With A Sprained Ankle

### Drugs (10)

- Chloroform
- [Diclofenac](https://trialight.com/data/asset/diclofenac-6bb6f2bf-7068-41cb-8e1d-c1c073cf27b3.md)
- Halothane
- Maprotiline
- Mefenamic acid
- Nifedipine
- Pioglitazone
- Primidone
- Rosiglitazone
- Troglitazone

---

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