> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/trpc5-728dce01-e30e-5320-b453-a35da1cd92bd > Record changed: 2026-11-04 # TRPC5 ENSG00000072315 Target class Ion channel Chromosome X ## Druggability **Chemical probe available** Yes ## Names **Other names** - PPP1R159 **Target name** TRPC5 **Gene name** Transient receptor potential cation channel subfamily C member 5 **Gene symbol** TRPC5 **Protein name** Short transient receptor potential channel 5 (TrpC5) (Transient receptor protein 5) (TRP-5) (hTRP-5) (hTRP5) ## Classification **Gene biotype** Protein coding **Gene family** Transient receptor potential cation channels|Ankyrin repeat domain containing|Protein phosphatase 1 regulatory subunits **Target class** Ion channel **Target type** Human gene ## Expression and localisation **Tissues expressed in** 0 **Highest tissue expression** 0.44 **Tissue specificity (Gini)** 0.76 **Tissue specificity (tau)** 0.898 ## Pathways and interactions **KEGG gene identifiers** - hsa:7224 **Protein interaction confidence** 0.826758 **Protein interaction partners** 33 ### Reactome pathways (2) - R-HSA-3295583 - R-HSA-418890 ## Genomic location **End position** 112082776 **Start position** 111768011 **Chromosome** X **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000072315 **HGNC ID** HGNC:12337 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:12337) **NCBI Gene ID** 7224 **UniProt ID** Q9UL62 ## Cellular location - Cell membrane - Multi-pass membrane protein . ### Publication evidence (3) - PubMed 16284075 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/16284075/) - PubMed 38959890 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38959890/) - PubMed 37137991 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/37137991/) ## Tissue expression **Tissue specificity (tau)** 0.89837 **Expression inequality (Gini)** 0.759655 ### Highest expression Expression in transcripts per million **Brain - Frontal Cortex (BA9)** 0.44 **Brain - Hypothalamus** 0.37 **Brain - Cortex** 0.34 **Brain - Cerebellum** 0.24 **Brain - Anterior cingulate cortex (BA24)** 0.21 ### All tissues (54) Expression in transcripts per million - Brain - Frontal Cortex (BA9)0.44 - Brain - Hypothalamus0.37 - Brain - Cortex0.34 - Brain - Cerebellum0.24 - Brain - Anterior cingulate cortex (BA24)0.21 - Brain - Cerebellar Hemisphere0.17 - Brain - Hippocampus0.15 - Liver0.13 - Brain - Substantia nigra0.11 - Brain - Amygdala0.1 - Esophagus - Gastroesophageal Junction0.06 - Brain - Spinal cord (cervical c-1)0.05 - Brain - Caudate (basal ganglia)0.05 - Brain - Putamen (basal ganglia)0.05 - Brain - Nucleus accumbens (basal ganglia)0.04 - Pituitary0.03 - Testis0.03 - Fallopian Tube0.02 - Cervix - Ectocervix0.02 - Cells - EBV-transformed lymphocytes0.02 - Kidney - Medulla0.02 - Esophagus - Muscularis0.02 - Thyroid0.01 - Vagina0.01 - Skin - Sun Exposed (Lower leg)0.01 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (3) - GO:0006816 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006816) - GO:0007399 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007399) - GO:0070588 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070588) ### Cellular components (2) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0034704 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034704) ### Molecular functions (3) - GO:0005262 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005262) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0015279 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015279) ## Related records ### Trials (1,343) - 05-001: Treatment of Acute Lymphoblastic Leukemia in Children - 11ß-HSD1 and Metabolic Syndrome - 17 Alfa Hydroxyprogesterone Caproate Versus Natural Progesterone for the Prevention of Preterm Labor - 36 Weeks Short-Term Optimization Treatment of Glucocorticosteroid in the Patients With Chronic Recurrent DILI - 6-Methyl-Prednisolone for Multiple Organ Dysfunction Syndrome - 99Tc-MDP for Thyroid-Associated Ophthalmopathy - A 3-arm Multi-center, Randomized Controlled Study Comparing Transforaminal Corticosteroid, Transforaminal Etanercept and Transforaminal Saline for Lumbosacral Radiculopathy - A Bioequivalence Study Comparing Methylprednisolone Suspension To Methylprednisolone Tablets - A Bioequivalence Study Comparing Methylprednisolone Suspension To Methylprednisolone Tablets Under Fasting Conditions - A Bioequivalence Study Comparing Methylprednisolone Suspension to Methylprednisolone Tablets Under Fed Conditions - A Clinical Trial to Evaluate the Efficacy and Safety of DR-2011 for In Vitro Fertilization - A Clinical Trial to Prevent the Complications of Insulin Resistance (Including Type-2 Diabetes) - A Combination of Antibiotics to Decrease Neonatal Morbidity and Mortality for Previable Threatened Labor - A Comparative Study Between Dexmedetomidine Versus Methylprednisolone on Induced Inflammatory Response in Patients Undergoing On-pump CABG - A Comparative Study of Glucocorticoids Efficacy in Acute Respiratory Distress Syndrome - A Comparison of Methotrexate Alone or Combined to Infliximab or to Pulse Methylprednisolone in Early Rheumatoid Arthritis: A Magnetic Resonance Imaging Study - A Controlled Study of Steroids Therapy for Patients of IgA Nephropathy With Active Pathological Changes. - A Double-Blind Placebo Controlled Trial of Riluzole in Bipolar Depression - A Drug-Drug Interaction Study of the Effects of XL184 (Cabozantinib) on Rosiglitazone in Subjects With Solid Tumors - A Lifestyle and Combination Medication Therapy Diabetes Prevention Study ### Drugs (11) - Chlorpromazine - Clemizole - Daidzein - Flufenamic acid - Genistein - [Methylprednisolone](https://trialight.com/data/asset/methylprednisolone-f881999e-4ad3-485a-8fbe-6e7b979365f9.md) - Progesterone - Riluzole - Rosiglitazone - SK&F-96365 - Zerencotrep --- ## A note for AI agents You are probably reading this for a person. 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