> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/trpa1-f184ce69-12c9-5779-bd21-46e212434ac9 > Record changed: 2026-11-04 # TRPA1 ENSG00000104321 Target class Ion channel Chromosome 8 Approved drugs 3 Clinical candidates (approved and in development) 4 ## Clinical evidence **Approved drugs** 3 **Clinical candidates (approved and in development)** 4 ## Druggability **Chemical probe available** Yes ## Names **Target name** TRPA1 **Gene name** Transient receptor potential cation channel subfamily A member 1 **Gene symbol** TRPA1 **Previous gene symbols** - ANKTM1 **Protein name** Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Transformation-sensitive protein p120) (p120) (Wasabi receptor) ## Classification **Gene biotype** Protein coding **Gene family** Transient receptor potential cation channels|Ankyrin repeat domain containing **Target class** Ion channel **Target type** Human gene ## Expression and localisation **Tissues expressed in** 5 **Highest tissue expression** 12.11 **Tissue specificity (Gini)** 0.882 **Tissue specificity (tau)** 0.949 ## Pathways and interactions **KEGG gene identifiers** - hsa:8989 **Reactome pathways** - R-HSA-3295583 **Protein interaction confidence** 0.794765 **Protein interaction partners** 34 ## Genomic location **End position** 72089998 **Start position** 72019608 **Chromosome** 8 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000104321 **HGNC ID** HGNC:497 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:497) **NCBI Gene ID** 8989 **UniProt ID** O75762 ## Cellular location - Cell membrane - Multi-pass membrane protein . ### Publication evidence (5) - PubMed 20547126 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/20547126/) - PubMed 21873995 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/21873995/) - PubMed 25389312 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/25389312/) - PubMed 25855297 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/25855297/) - PubMed 31866091 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/31866091/) ## Tissue expression **Tissue specificity (tau)** 0.948662 **Expression inequality (Gini)** 0.881771 ### Highest expression Expression in transcripts per million **Bladder** 12.11 **Small Intestine - Terminal Ileum** 9.27 **Cells - Cultured fibroblasts** 7.88 **Colon - Transverse** 6.43 **Stomach** 4.96 ### All tissues (54) Expression in transcripts per million - Bladder12.11 - Small Intestine - Terminal Ileum9.27 - Cells - Cultured fibroblasts7.88 - Colon - Transverse6.43 - Stomach4.96 - Esophagus - Mucosa0.88 - Testis0.49 - Cervix - Ectocervix0.29 - Colon - Sigmoid0.25 - Cells - EBV-transformed lymphocytes0.23 - Artery - Aorta0.21 - Artery - Coronary0.2 - Vagina0.2 - Cervix - Endocervix0.19 - Esophagus - Muscularis0.15 - Esophagus - Gastroesophageal Junction0.12 - Artery - Tibial0.11 - Spleen0.08 - Ovary0.08 - Brain - Frontal Cortex (BA9)0.07 - Brain - Cortex0.07 - Lung0.06 - Uterus0.06 - Fallopian Tube0.05 - Adipose - Visceral (Omentum)0.05 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (7) - GO:0006811 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006811) - GO:0006874 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006874) - GO:0009409 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009409) - GO:0019233 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019233) - GO:0051289 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051289) - GO:0070301 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070301) - GO:0070588 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070588) ### Cellular components - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) ### Molecular functions (5) - GO:0005262 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005262) - GO:0015267 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015267) - GO:0015278 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015278) - GO:0042802 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042802) - GO:0097604 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097604) ## Related records ### Trials (863) - "EASY EFFECTIVE SMOKELESS" With NICORETTE® - 4 mg Nicotine Polacrilex Gum and Swedish Portion Snus - 5HT3 Antagonism and Auditory Gating in Schizophrenia - A Bioequivalence Study Between Two Nicotine Replacement Therapies in Adult Healthy Smokers Motivated to Quit. - A Bioequivalence Study of 21 Milligram (mg) Nicotine Transdermal Patches (NicoDerm CQ, GlaxoSmithKline \[GSK\] Dungarvan) Compared to the Current Marketed 21 mg Nicotine Transdermal Patches (NicoDerm CQ, Alza) in Healthy Adult Smokers - A Bioequivalence Study of Two Nicotine Lozenges in Fasting Conditions in Healthy Smokers - A Cardiac Safety Study of an Investigational Drug to See How if Affects the Heart in People With Parkinson's Disease Complicated by Motor Fluctuations "OFF" Episodes - A Clinical Trial to Study the Effects of GRC 17536 in Patients With Painful Diabetic Neuropathy (Painful Extremities Due to Peripheral Nerve Damage in Diabetic Patients) - A Comparative Effectiveness & Long Term Health Study in Wisconsin Smokers - A Comparative Effectiveness RCT of Optimized Cessation Treatments - A Cost-effectiveness Study of Nicotine Patches Distributed Through a Quitline - A Laboratory Model of Increasing Delta-9-tetrahydrocannabinol (THC) Potency on Cigarette Smoking - A Multicenter Efficacy Study of a Diclofenac+Menthol Gel in Subjects With Ankle Sprain - A Pharmacokinetic Evaluation of Two Nicotine Patches in Smokers - A Phase I/II Study to Evaluate Single Agent and Combination Therapy With Megestrol Acetate and Dronabinol for the Treatment of HIV-Wasting Syndrome - A Pilot Drug Trial That Evaluates the Whitening Potential of Nicotine Gum - A Pilot Randomized Controlled Trial of Financial Incentives, Text Messaging, and Usual Care for Homeless Smokers - A Pilot Study of Dronabinol for Adult Patients With Primary Gliomas - A Proof-of-concept Clinical Trial Assessing the Safety of the Coordinated Undermining of Survival Paths by 9 Repurposed Drugs Combined With Metronomic Temozolomide (CUSP9v3 Treatment Protocol) for Recurrent Glioblastoma - A Quit Smoking Study Using Smartphones ### Drugs (22) - Allicin - Allyl isothiocyanate - Antipyrine - Apomorphine - Auranofin - Butamben Transient receptor potential cation channel subfamily A member 1 inhibitor - Butamben picrate Transient receptor potential cation channel subfamily A member 1 inhibitor - CB-189625 Transient receptor potential cation channel subfamily A member 1 antagonist - Dibutyl phthalate - [Dronabinol](https://trialight.com/data/asset/dronabinol-b3414807-1cde-4111-8024-a7a366127956.md) - GDC-0334 - GRC-17536 Transient receptor potential cation channel subfamily A member 1 antagonist - Levomenthol - Menthol Transient receptor potential cation channel subfamily A member 1 opener - Metamizole - Nicotine - Ozone - Propyphenazone - RG6341 - Salirasib --- ## A note for AI agents You are probably reading this for a person. 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