> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/top2b-cadf7290-df6f-57c4-92f4-00db8e526bfa > Record changed: 2026-11-04 # TOP2B ENSG00000077097 Target class Enzyme Chromosome 3 Approved drugs 5 Clinical candidates (approved and in development) 10 ## Clinical evidence **Approved drugs** 5 **ClinGen gene-disease validity** Moderate **Clinical candidates (approved and in development)** 10 ## Druggability **Chemical probe available** No ## Names **Target name** TOP2B **Gene name** DNA topoisomerase II beta **Gene symbol** TOP2B **Protein name** DNA topoisomerase 2-beta (EC 5.6.2.2) (DNA topoisomerase II, beta isozyme) ### Other names (2) - top2beta - TOPIIB ## Classification **Gene biotype** Protein coding **Gene family** Topoisomerases **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Protein localisation evidence grade** Enhanced **Highest tissue expression** 134.38 **Tissue specificity (Gini)** 0.233 **Tissue specificity (tau)** 0.595 ## Pathways and interactions **KEGG gene identifiers** - hsa:7155 **Reactome pathways** - R-HSA-4615885 **Protein interaction confidence** 0.804867 **Protein interaction partners** 15 ## Genomic location **End position** 25664973 **Start position** 25597978 **Chromosome** 3 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000077097 **HGNC ID** HGNC:11990 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:11990) **NCBI Gene ID** 7155 **UniProt ID** Q02880 ## Cellular location - Nucleus, nucleolus . Nucleus, nucleoplasm . Nucleus . - Nucleoplasm ### Publication evidence (3) - PubMed 8299728 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/8299728/) - PubMed 9155056 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/9155056/) - PubMed 19690332 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/19690332/) ## Tissue expression **Tissue specificity (tau)** 0.595244 **Expression inequality (Gini)** 0.23288 ### Highest expression Expression in transcripts per million **Brain - Cerebellar Hemisphere** 134.38 **Brain - Cerebellum** 106.57 **Cells - EBV-transformed lymphocytes** 93.15 **Uterus** 92.55 **Cervix - Endocervix** 88.5 ### All tissues (54) Expression in transcripts per million - Brain - Cerebellar Hemisphere134.38 - Brain - Cerebellum106.57 - Cells - EBV-transformed lymphocytes93.15 - Uterus92.55 - Cervix - Endocervix88.5 - Ovary85.75 - Nerve - Tibial80.86 - Artery - Tibial79.98 - Bladder79.37 - Fallopian Tube76.91 - Cells - Cultured fibroblasts75.06 - Vagina75.06 - Thyroid73.11 - Colon - Sigmoid72.06 - Cervix - Ectocervix71.95 - Esophagus - Gastroesophageal Junction67.38 - Artery - Aorta66.4 - Esophagus - Muscularis65.98 - Prostate62.36 - Skin - Sun Exposed (Lower leg)60.55 - Skin - Not Sun Exposed (Suprapubic)60.33 - Artery - Coronary60.26 - Lung59.54 - Spleen56.49 - Breast - Mammary Tissue56.46 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (3) - GO:0006265 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006265) - GO:0030183 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030183) - GO:0045870 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045870) ### Cellular components (5) - GO:0000792 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000792) - GO:0005634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) - GO:0005654 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005654) - GO:0005730 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005730) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) ### Molecular functions (3) - GO:0003682 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003682) - GO:0003918 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003918) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## Related records ### Trials (1,512) - 05-001: Treatment of Acute Lymphoblastic Leukemia in Children - 131I-MIBG With Myeloablative Chemotherapy and Autologous Stem Cell Transplantation for the Treatment of High-risk Neuroblastoma - 2006-32 Phase II Study of Rapidly Recycled High Dose DTPACE - 2015-12: A Study Exploring the Use of Early and Late Consolidation/Maintenance Therapy - A Clinical Study of Gocatamig (MK-6070) and Infinatamab Deruxtecan (MK-2400) in People With Small Cell Lung Cancer (MK-6070-003) - A Clinical Study of SHR-1316 (SC) Combined With Carboplatin and Etoposide as First-line Treatment for Extensive Stage Small Cell Lung Cancer - A Clinical Study to Evaluate the Efficacy and Safety of HLX07 Combination Therapy in Patients With Extensive Small Cell Lung Cancer - A Clinical Trial of Chidamide Combined With Etoposide in Relapsed or Refractory NK/T-cell Lymphoma - A Clinical Trial of Decitabine in Relapsed or Refractory T-lymphoblastic Lymphoma - A Clinical Trial of Endoscopic Surgery Followed by Chemotherapy and Proton Radiation for the Treatment of Tumors in the Sinus and Nasal Passages - A Clinical Trial of LBL-024 Combined With Etoposide and Platinum in Patients With Advanced Neuroendocrine Carcinoma - A Clinical Trial on Topotect® (Dexrazoxane) in the Treatment of Accidental Extravasation of Anthracyclines - A Feasibility Study of Co-administering Combination Antiretroviral Therapy (cART) and R-EPOCH Chemotherapy for the Management of ARL - A Global Study of Midostaurin in Combination With Chemotherapy to Evaluate Safety, Efficacy and Pharmacokinetics in Newly Diagnosed Pediatric Patients With FLT3 Mutated AML - A Global Study of Novel Agents in Paediatric and Adolescent Relapsed and Refractory B-cell Non-Hodgkin Lymphoma - A Multi-cohort Study of Efbemalenograstim Alfa Injection for Preventing ANC Reduction in Solid Tumor Patients Post Immune-chemotherapy. - A Multi-Institutional Pilot Study of Allogeneic Hematopoietic Stem Cell Transplantation for Patients With Malignant Neuro-Epithelial and Other Solid Tumors - A Multicenter Phase II Trial to Evaluate Rechallenge With Platinum-based Chemotherapy (Carboplatin, Etoposide) for Progression During Tarlatamab Therapy in Relapsed Extensive Disease Small-cell Lung Cancer (SCLC) - A Multicenter, Study of the Safety and Pharmacokinetics of Intravenously Infused Berubicin in Pediatric Patients With Progressive, Refractory, or Recurrent High Grade Gliomas - A Phase 1/2, Open-Label, Dose Escalation, Safety and Tolerability Study of INCB050465 and Itacitinib in Subjects With Previously Treated B-Cell Malignancies (CITADEL-101) ### Drugs (12) - Aclarubicin - Amsacrine DNA topoisomerase II inhibitor - Becatecarin DNA topoisomerase II inhibitor - Berubicin DNA topoisomerase II inhibitor - Berubicin hydrochloride DNA topoisomerase II inhibitor - C-1311 DNA topoisomerase II inhibitor - Dexrazoxane DNA topoisomerase II inhibitor - Dexrazoxane hydrochloride DNA topoisomerase II inhibitor - [Etoposide](https://trialight.com/data/asset/etoposide-796d2f5b-cce5-4ec5-8a1f-c80f2bfbc7aa.md) DNA topoisomerase II inhibitor - Pazufloxacin DNA topoisomerase II inhibitor - Teniposide DNA topoisomerase II inhibitor - Vosaroxin DNA topoisomerase II inhibitor --- ## A note for AI agents You are probably reading this for a person. 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