> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/top2a-ee962484-09ab-5c5a-8b7b-1242173c1ca8 > Record changed: 2026-10-13 # TOP2A ENSG00000131747 Target class Enzyme Chromosome 17 Approved drugs 13 Clinical candidates (approved and in development) 22 ## Clinical evidence **Approved drugs** 13 **Clinical candidates (approved and in development)** 22 ## Druggability **Chemical probe available** No ## Names **Target name** TOP2A **Gene name** DNA topoisomerase II alpha **Gene symbol** TOP2A **Previous gene symbols** - TOP2 **Protein name** DNA topoisomerase 2-alpha (EC 5.6.2.2) (DNA topoisomerase II, alpha isozyme) ### Other names (2) - TOP2alpha - TOPIIA ## Classification **Gene biotype** Protein coding **Gene family** Topoisomerases **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 16 **Protein localisation evidence grade** Supported **Highest tissue expression** 150.71 **Tissue specificity (Gini)** 0.888 **Tissue specificity (tau)** 0.971 ## Pathways and interactions **KEGG gene identifiers** - hsa:7153 **Protein interaction confidence** 0.85289 **Protein interaction partners** 136 ### Reactome pathways (2) - R-HSA-1362277 - R-HSA-4615885 ## Genomic location **End position** 40417896 **Start position** 40388525 **Chromosome** 17 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000131747 **HGNC ID** HGNC:11989 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:11989) **NCBI Gene ID** 7153 **UniProt ID** P11388 ## Cellular location - Cytoplasm . Nucleus, nucleoplasm . Nucleus . Nucleus, nucleolus . - Nucleoli - Nucleoplasm ### Publication evidence (4) - PubMed 9155056 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/9155056/) - PubMed 8299728 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/8299728/) - PubMed 17567603 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/17567603/) - PubMed 22013166 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/22013166/) ## Tissue expression **Tissue specificity (tau)** 0.971476 **Expression inequality (Gini)** 0.887819 ### Highest expression Expression in transcripts per million **Cells - EBV-transformed lymphocytes** 150.71 **Testis** 78.92 **Cells - Cultured fibroblasts** 66.69 **Esophagus - Mucosa** 20.5 **Small Intestine - Terminal Ileum** 8.4 ### All tissues (54) Expression in transcripts per million - Cells - EBV-transformed lymphocytes150.71 - Testis78.92 - Cells - Cultured fibroblasts66.69 - Esophagus - Mucosa20.5 - Small Intestine - Terminal Ileum8.4 - Skin - Sun Exposed (Lower leg)7.17 - Skin - Not Sun Exposed (Suprapubic)6.79 - Vagina6.73 - Colon - Transverse5.87 - Spleen5.31 - Lung2.37 - Stomach1.68 - Minor Salivary Gland1.51 - Adrenal Gland1.19 - Whole Blood1.11 - Artery - Coronary1 - Breast - Mammary Tissue0.92 - Adipose - Subcutaneous0.86 - Thyroid0.79 - Artery - Aorta0.75 - Adipose - Visceral (Omentum)0.72 - Prostate0.69 - Cervix - Endocervix0.69 - Bladder0.67 - Nerve - Tibial0.64 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (7) - GO:0006265 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006265) - GO:0006325 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006325) - GO:0006974 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006974) - GO:0007059 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007059) - GO:0030263 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030263) - GO:0043065 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043065) - GO:0045870 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045870) ### Cellular components (9) - GO:0000228 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000228) - GO:0005634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) - GO:0005654 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005654) - GO:0005730 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005730) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0005814 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005814) - GO:0009330 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009330) - GO:0032991 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032991) - GO:1990904 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1990904) ### Molecular functions (12) - GO:0000287 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000287) - GO:0003677 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003677) - GO:0003682 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003682) - GO:0003723 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003723) - GO:0003918 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003918) - GO:0005080 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005080) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0008094 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008094) - GO:0008301 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008301) - GO:0042803 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042803) - GO:0043130 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043130) - GO:0046982 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046982) ## Related records ### Trials (3,767) - 05-001: Treatment of Acute Lymphoblastic Leukemia in Children - 131I-MIBG With Myeloablative Chemotherapy and Autologous Stem Cell Transplantation for the Treatment of High-risk Neuroblastoma - 2015-12: A Study Exploring the Use of Early and Late Consolidation/Maintenance Therapy - 3-AP and Doxorubicin In Treating Patients With Metastatic or Refractory Solid Tumors - 4B951, Combination Chemotherapy in Treating Patients With Bladder Cancer - 6 vs 3 Cycles of Neoadjuvant Chemotherapy for Potentially Resectable Locally Advanced Thymic Epithelial Tumors - 6,8-Bis(Benzylthio)Octanoic Acid, Cytarabine, and Daunorubicin Hydrochloride in Treating Older Patients With Newly Diagnosed Acute Myeloid Leukemia - 64-Cu Labeled Brain PET/MRI for MM-302 in Advanced HER2+ Cancers With Brain Mets - 8 Continuous vs 8 Intermittent Cycles in First and Second Line in HER2/Neu Neg Metastatic Breast Cancer - 9-ING-41 in Patients With Advanced Cancers - A 3 Arm Randomized Study on Health-related QoL of Elderly Patients With Advanced Soft Tissue Sarcoma - A Bioequivalence Study of Doxorubicin Hydrochloride Liposome Injection - A Bridging Study of Liposomal Cytarabine-Daunorubicin in Treating Olderly Patients With Treatment-naive High-Risk (Secondary) Acute Myeloid Leukemia - A Clinical Study of ANX005 and IVIG in Subjects With Guillain Barré Syndrome (GBS) - A Clinical Study of Boserolimab (MK-5890) With Pembrolizumab and Chemotherapy in People With Early Triple-Negative Breast Cancer (MK-5890-003) - A Clinical Study of Gocatamig (MK-6070) and Infinatamab Deruxtecan (MK-2400) in People With Small Cell Lung Cancer (MK-6070-003) - [A Clinical Study of Patritumab Deruxtecan to Treat Breast Cancer (MK-1022-016)](https://trialight.com/data/trial/a-clinical-study-of-patritumab-deruxtecan-to-treat-breast-1962c52e-34fb-4ad2-b312-330e0edf6f40.md) - [A Clinical Study of Raludotatug Deruxtecan in People With Ovarian Cancer (MK-5909-003)](https://trialight.com/data/trial/a-clinical-study-of-raludotatug-deruxtecan-in-people-with-6b1e5a4a-56bb-4891-a239-d464dd0753c5.md) - [A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast Cancer (MK-2870-032)](https://trialight.com/data/trial/a-clinical-study-of-sacituzumab-tirumotecan-sac-tmt-mk-2870-47421f86-889b-4c0b-a65c-14ed97707a1e.md) - A Clinical Study of SHR-1316 (SC) Combined With Carboplatin and Etoposide as First-line Treatment for Extensive Stage Small Cell Lung Cancer ### Drugs (26) - Aldoxorubicin DNA topoisomerase II alpha inhibitor - Amrubicin DNA topoisomerase II alpha inhibitor - Amrubicin hydrochloride DNA topoisomerase II alpha inhibitor - Amsacrine DNA topoisomerase II inhibitor - Becatecarin DNA topoisomerase II inhibitor - Berubicin DNA topoisomerase II inhibitor - Berubicin hydrochloride DNA topoisomerase II inhibitor - C-1311 DNA topoisomerase II inhibitor - [Daunorubicin](https://trialight.com/data/asset/daunorubicin-903e3e75-4637-461c-9ca8-608fdf707576.md) DNA topoisomerase II alpha inhibitor - Daunorubicin citrate DNA topoisomerase II alpha inhibitor - Daunorubicin hydrochloride DNA topoisomerase II alpha inhibitor - Dexrazoxane DNA topoisomerase II inhibitor - Dexrazoxane hydrochloride DNA topoisomerase II inhibitor - Doxorubicin DNA topoisomerase II alpha inhibitor - [Doxorubicin hydrochloride](https://trialight.com/data/asset/doxorubicin-hydrochloride-2e3493ba-9766-475e-aa7d-f2debf111de5.md) DNA topoisomerase II alpha inhibitor - Etoposide DNA topoisomerase II inhibitor - [Etoposide phosphate](https://trialight.com/data/asset/etoposide-phosphate-97b820e3-fe22-4590-9942-e33299436d3a.md) DNA topoisomerase II alpha inhibitor - Gancotamab DNA topoisomerase II alpha inhibitor - Idarubicin DNA topoisomerase II alpha inhibitor - [Idarubicin hydrochloride](https://trialight.com/data/asset/idarubicin-hydrochloride-2d428c9b-e95a-4e2e-a059-ddf75f537db0.md) DNA topoisomerase II alpha inhibitor --- ## A note for AI agents You are probably reading this for a person. 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