> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/top1mt-e2172f07-37c5-503a-a9e8-ad2ff56a5ca9 > Record changed: 2026-11-04 # TOP1MT ENSG00000184428 Target class Enzyme Chromosome 8 ## Druggability **Chemical probe available** No ## Names **Target name** TOP1MT **Gene name** DNA topoisomerase I mitochondrial **Gene symbol** TOP1MT **Protein name** DNA topoisomerase I, mitochondrial (TOP1mt) (EC 5.6.2.1) ## Classification **Gene biotype** Protein coding **Gene family** Topoisomerases|Mitochondrial nucleoid associated proteins **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 51 **Protein localisation evidence grade** Supported **Highest tissue expression** 20.1 **Tissue specificity (Gini)** 0.368 **Tissue specificity (tau)** 0.681 ## Pathways and interactions **KEGG gene identifiers** - hsa:116447 **Protein interaction confidence** 0.8321 **Protein interaction partners** 10 ## Genomic location **End position** 143359979 **Start position** 143304384 **Chromosome** 8 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000184428 **HGNC ID** HGNC:29787 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:29787) **NCBI Gene ID** 116447 **UniProt ID** Q969P6 ## Cellular location - Mitochondrion . - Mitochondria ### Publication evidence - PubMed 11526219 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/11526219/) ## Tissue expression **Tissue specificity (tau)** 0.680719 **Expression inequality (Gini)** 0.367638 ### Highest expression Expression in transcripts per million **Testis** 20.1 **Ovary** 18.68 **Cervix - Endocervix** 16.81 **Cervix - Ectocervix** 15.88 **Thyroid** 12.84 ### All tissues (54) Expression in transcripts per million - Testis20.1 - Ovary18.68 - Cervix - Endocervix16.81 - Cervix - Ectocervix15.88 - Thyroid12.84 - Vagina12.29 - Skin - Not Sun Exposed (Suprapubic)12.07 - Bladder11.76 - Uterus11.34 - Skin - Sun Exposed (Lower leg)10.68 - Cells - Cultured fibroblasts9.26 - Fallopian Tube8.78 - Esophagus - Mucosa8.68 - Prostate8.38 - Breast - Mammary Tissue8.15 - Adrenal Gland8.13 - Cells - EBV-transformed lymphocytes7.86 - Adipose - Subcutaneous7.8 - Adipose - Visceral (Omentum)7.4 - Artery - Aorta7.28 - Colon - Sigmoid7.21 - Lung7.12 - Spleen7.11 - Liver6.97 - Nerve - Tibial6.96 And 29 more, listed on the interactive page. ## Biological functions ### Cellular components (2) - GO:0005739 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005739) - GO:0042645 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042645) ## Related records ### Trials (264) - 9-ING-41 in Pediatric Patients With Refractory Malignancies. - A Bioequivalence Study of Two Oral Formulations of Topotecan in Patients With Advanced Solid Tumors - A Multi-Arm, Platform Trial For Relapsed Neuroblastoma - a Multicenter Clinical Trial for the Treatment of Children and Adolescents With Soft Tissue Sarcoma Stage 4 - A Pharmacokinetic Study of Oral Cyclophosphamide and Topotecan in Children With Recurrent Solid Tumors - A Phase 1b Study of Sevacizumab in Combination With Chemotherapy in Chinese Patients With Platinum-Resistant Recurrent Ovarian Cancer. - A Phase 2 Study Comparing TAS-102 Versus Topotecan or Amrubicin to Treat Small Cell Lung Cancer Following Platinum-Based Chemotherapy - A Phase I Study of CCI-779 (Temsirolimus) in Combination With Topotecan in Patients With Gynecologic Malignancies - A Phase I Study of Oral Topotecan as a Radiosensitizing Agent in Patients With Rectal Carcinoma - A Phase I Topotecan Study in Subjects With Cancer and Impaired Renal Function - A Phase I/II Study of Induction Chemotherapy With Daunorubicin, Cytarabine, Topotecan and Etoposide - A Phase II Study of Paclitaxel and Topotecan With Filgrastim-SD/01 Support For Relapsed and Refractory Aggressive Non-Hodgkin's Lymphoma - A Phase II Study of Topotecan in Children With Recurrent Wilms Tumor - A Phase III Study of BD0801 Combined With Chemotherapy in Recurrent, Platinum-resistant Epithelial Ovarian Cancer - A Pilot Trial of Oral Topotecan for the Treatment of Refractory Advanced Solid Neoplasms Expressing HIF-1a - A Prospective International Multicenter Clinical Trial for Eyes With Relapsed Retinoblastoma - A Randomized Study to Compare the Efficacy and Safety of Belotecan and Topotecan as Monotherapy for Sensitive-Relapsed Small Cell Lung Cancer - A Study Comparing BL-B01D1 With Topotecan in Patients With Recurrent Small Cell Lung Cancer(PANKU-Lung03) - A Study Comparing BL-M07D1 With Physician's Choice of Chemotherapy in Patients With HER2-Expressing Platinum-Resistant Recurrent Epithelial Ovarian Cancer, Fallopian Tube Cancer, and Primary Peritoneal Cancer - A Study Evaluating BSI-201 in Combination With Chemotherapeutic Regimens in Subjects With Advanced Solid Tumors ### Drugs (1) - [Topotecan](https://trialight.com/data/asset/topotecan-6d6bd0ac-4e76-43a7-b97a-0a62e439a24a.md) --- ## A note for AI agents You are probably reading this for a person. 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