> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/top1-efb273d0-ed4a-5281-9372-90a0abb25f90 > Record changed: 2026-10-13 # TOP1 ENSG00000198900 Target class Enzyme Chromosome 20 Approved drugs 4 Clinical candidates (approved and in development) 24 ## Clinical evidence **Approved drugs** 4 **Clinical candidates (approved and in development)** 24 ## Druggability **Chemical probe available** Yes ## Names **Target name** TOP1 **Gene name** DNA topoisomerase I **Gene symbol** TOP1 **Protein name** DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I) ## Classification **Gene biotype** Protein coding **Gene family** Topoisomerases **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Protein localisation evidence grade** Supported **Highest tissue expression** 133.84 **Tissue specificity (Gini)** 0.267 **Tissue specificity (tau)** 0.702 ## Pathways and interactions **KEGG gene identifiers** - hsa:7150 **Reactome pathways** - R-HSA-4615885 **Protein interaction confidence** 0.804327 **Protein interaction partners** 55 ## Genomic location **End position** 41124487 **Start position** 41028822 **Chromosome** 20 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000198900 **HGNC ID** HGNC:11986 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:11986) **NCBI Gene ID** 7150 **UniProt ID** P11387 ## Cellular location - Nucleus, nucleolus . Nucleus, nucleoplasm . Note=Diffuse nuclear localization with some enrichment in nucleoli. On CPT treatment, cleared from nucleoli into nucleoplasm. Sumoylated forms found in both nucleoplasm and nucleoli. - Nucleoli fibrillar center - Nucleoplasm ### Publication evidence - PubMed 12149243 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/12149243/) ## Tissue expression **Tissue specificity (tau)** 0.702232 **Expression inequality (Gini)** 0.267034 ### Highest expression Expression in transcripts per million **Cells - EBV-transformed lymphocytes** 133.84 **Cells - Cultured fibroblasts** 95.96 **Lung** 79.82 **Thyroid** 67.22 **Brain - Cerebellar Hemisphere** 60.28 ### All tissues (54) Expression in transcripts per million - Cells - EBV-transformed lymphocytes133.84 - Cells - Cultured fibroblasts95.96 - Lung79.82 - Thyroid67.22 - Brain - Cerebellar Hemisphere60.28 - Vagina59 - Spleen58.93 - Esophagus - Mucosa56.86 - Fallopian Tube56.23 - Cervix - Endocervix56.09 - Ovary54.83 - Adipose - Visceral (Omentum)54.35 - Small Intestine - Terminal Ileum54.08 - Uterus54.06 - Cervix - Ectocervix53.91 - Brain - Cerebellum49.96 - Skin - Sun Exposed (Lower leg)48.36 - Breast - Mammary Tissue47.15 - Pituitary46.41 - Skin - Not Sun Exposed (Suprapubic)46.23 - Adrenal Gland45.93 - Prostate45.69 - Bladder44.13 - Colon - Transverse43.78 - Nerve - Tibial43.54 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (5) - GO:0006265 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006265) - GO:0006338 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006338) - GO:0007623 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007623) - GO:0009410 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009410) - GO:0032922 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032922) ### Cellular components (7) - GO:0000228 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000228) - GO:0001650 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001650) - GO:0005634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) - GO:0005654 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005654) - GO:0005730 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005730) - GO:0032993 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032993) - GO:0036464 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0036464) ### Molecular functions (14) - GO:0000978 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000978) - GO:0003677 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003677) - GO:0003682 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003682) - GO:0003690 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003690) - GO:0003697 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003697) - GO:0003723 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003723) - GO:0003917 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003917) - GO:0004674 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004674) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0005524 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005524) - GO:0008301 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008301) - GO:0019904 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019904) - GO:0097100 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097100) - GO:0140693 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0140693) ## Related records ### Trials (2,285) - 131I-MIBG Alone VS. 131I-MIBG With Vincristine and Irinotecan VS131I-MIBG With Vorinostat - 131I-Omburtamab, in Recurrent Medulloblastoma and Ependymoma - 17-AAG and Irinotecan in Treating Patients With Locally Advanced or Metastatic Solid Tumors - 26-week Open Study of telmisartan40mg+amlodipine10mg or telmisartan80mg+amlodipine10 mg in Hypertension - 2nd-line Therapy With Nal-IRI After Gem/Nab-pac in Advanced Pancreatic Cancer - Predictive Role of 1st-line Therapy - 5-FU, Folinic Acid and Irinotecan (FOLFIRI) Plus Cetuximab Versus FOLFIRI Plus Bevacizumab in First Line Treatment Colorectal Cancer (CRC) - 5FU/LV, Irinotecan, Temozolomide and Bevacizumab for MGMT Silenced, Microsatellite Stable Metastatic Colorectal Cancer. - 7-Hydroxystaurosporine and Irinotecan Hydrochloride in Treating Patients With Metastatic or Unresectable Solid Tumors or Triple Negative Breast Cancer (Currently Accruing Only Triple-negative Breast Cancer Patients Since 6/8/2007) - 7-hydroxystaurosporine and Topotecan Hydrochloride in Treating Patients With Relapsed or Progressed Small Cell Lung Cancer - 9-ING-41 in Patients With Advanced Cancers - 9-ING-41 in Pediatric Patients With Refractory Malignancies. - A Bioequivalence Study of Two Oral Formulations of Topotecan in Patients With Advanced Solid Tumors - A Clinical Study of Exploring Camrelizumab in the Treatment of Colorectal Mucinous Adenocarcinoma(MAC) - A Clinical Study of Gimatecan in Advanced Ovarian Epithelial Cancer, Fallopian Tube Cancer or Primary Peritoneal Cancer - A Clinical Study of IMP4297 Capsule (JS109) Combined With Irinotecan in the Treatment of Advanced Malignant Solid Tumors - A Clinical Study of Liposomal Irinotecan for Second-Line Therapy in Metastatic Colorectal Cancer - A Clinical Study of MK-1084 With Other Treatments for Non-small Cell Lung Cancer (MK-3475-01F) - [A Clinical Study of Patritumab Deruxtecan to Treat Breast Cancer (MK-1022-016)](https://trialight.com/data/trial/a-clinical-study-of-patritumab-deruxtecan-to-treat-breast-1962c52e-34fb-4ad2-b312-330e0edf6f40.md) - A Clinical Study of TQB3616 Capsules Combined With Anlotinib Hydrochloride Capsules or Standard Chemotherapy Second-line and Above in the Treatment of Advanced Lung Cancer - A Clinical Study on the Treatment of Metastatic Colorectal Cancer at the Second-line or Beyond. ### Drugs (26) - 7-ethyl-10-hydroxycamptothecin DNA topoisomerase I inhibitor - 9-aminocamptothecin DNA topoisomerase I inhibitor - Afeletecan DNA topoisomerase I stabiliser - AR-67 DNA topoisomerase I inhibitor - Becatecarin DNA topoisomerase I inhibitor - Belotecan DNA topoisomerase I inhibitor - Camptothecin-20-O-propionate DNA topoisomerase I inhibitor - [Datopotamab deruxtecan](https://trialight.com/data/asset/datopotamab-deruxtecan-7c3e1007-5db7-4633-bfdb-335de1c23f10.md) DNA topoisomerase I inhibitor - Diflomotecan DNA topoisomerase I inhibitor - Edotecarin DNA topoisomerase I inhibitor - Etirinotecan pegol DNA topoisomerase I inhibitor - Exatecan DNA topoisomerase I inhibitor - Gimatecan DNA topoisomerase I inhibitor - Irinotecan DNA topoisomerase I inhibitor - [Irinotecan hydrochloride](https://trialight.com/data/asset/irinotecan-hydrochloride-c1f6b7df-7c76-40f1-92fe-12d71b1f3b25.md) DNA topoisomerase I inhibitor - Irinotecan sucrosofate DNA topoisomerase I inhibitor - Karenitecin DNA topoisomerase I inhibitor - Labetuzumab govitecan DNA topoisomerase 1 inhibitor - Mureletecan DNA topoisomerase I inhibitor - [Patritumab deruxtecan](https://trialight.com/data/asset/patritumab-deruxtecan-4c50b491-6b8e-4e9b-a05d-3ab136f301a9.md) DNA topoisomerase I inhibitor --- ## A note for AI agents You are probably reading this for a person. 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