> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/tnfsf4-ba3c51c3-2d56-5f55-962b-60fd0df0e3be > Record changed: 2026-10-13 # TNFSF4 ENSG00000117586 Target class Secreted protein Chromosome 1 Approved drugs 0 Clinical candidates (approved and in development) 2 ## Clinical evidence **Approved drugs** 0 **Clinical candidates (approved and in development)** 2 ## Druggability **Chemical probe available** No ## Names **Target name** TNFSF4 **Gene name** TNF superfamily member 4 **Gene symbol** TNFSF4 **Previous gene symbols** - TXGP1 **Protein name** Tumor necrosis factor ligand superfamily member 4 (Glycoprotein Gp34) (OX40 ligand) (OX40L) (TAX transcriptionally-activated glycoprotein 1) (CD antigen CD252) ### Other names (3) - OX-40L - gp34 - CD252 ## Classification **Gene biotype** Protein coding **Gene family** CD molecules|Tumor necrosis factor superfamily **Target class** Secreted protein **Target type** Human gene ## Expression and localisation **Tissues expressed in** 32 **Protein localisation evidence grade** Approved **Highest tissue expression** 9.79 **Tissue specificity (Gini)** 0.43 **Tissue specificity (tau)** 0.846 ## Pathways and interactions **KEGG gene identifiers** - hsa:7292 **Reactome pathways** - R-HSA-5669034 **Protein interaction confidence** 0.817034 **Protein interaction partners** 29 ## Genomic location **End position** 173477583 **Start position** 173162645 **Chromosome** 1 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000117586 **HGNC ID** HGNC:11934 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:11934) **NCBI Gene ID** 7292 **UniProt ID** P23510 ## Cellular location - Membrane - Single-pass type II membrane protein. - Nucleoplasm - Vesicles ## Tissue expression **Tissue specificity (tau)** 0.846243 **Expression inequality (Gini)** 0.429709 ### Highest expression Expression in transcripts per million **Cells - EBV-transformed lymphocytes** 9.79 **Cells - Cultured fibroblasts** 6.49 **Testis** 5.35 **Esophagus - Gastroesophageal Junction** 4.16 **Brain - Cerebellar Hemisphere** 3.7 ### All tissues (54) Expression in transcripts per million - Cells - EBV-transformed lymphocytes9.79 - Cells - Cultured fibroblasts6.49 - Testis5.35 - Esophagus - Gastroesophageal Junction4.16 - Brain - Cerebellar Hemisphere3.7 - Brain - Cerebellum3.04 - Pituitary3.02 - Esophagus - Muscularis2.64 - Spleen2.44 - Lung2.33 - Prostate2.26 - Cervix - Endocervix1.96 - Fallopian Tube1.86 - Nerve - Tibial1.86 - Cervix - Ectocervix1.8 - Ovary1.72 - Uterus1.62 - Artery - Aorta1.59 - Adrenal Gland1.54 - Vagina1.52 - Bladder1.49 - Colon - Sigmoid1.42 - Artery - Coronary1.36 - Brain - Spinal cord (cervical c-1)1.22 - Adipose - Subcutaneous1.19 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (9) - GO:0007165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007165) - GO:0008284 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008284) - GO:0032700 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032700) - GO:0032729 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032729) - GO:0032753 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032753) - GO:0032755 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032755) - GO:0050729 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050729) - GO:0071222 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071222) - GO:0071380 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071380) ### Cellular components (3) - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0009986 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009986) ### Molecular functions (2) - GO:0005102 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005102) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## Related records ### Trials (23) - [A Bioequivalence Study of Amlitelimab Delivered by 2 Different Devices in Healthy Adult Participants](https://trialight.com/data/trial/a-bioequivalence-study-of-amlitelimab-delivered-by-2-d69b0e6b-d2f6-4e27-97de-cc240f0fbc85.md) - A Phase 2a/b Study of the Efficacy and Safety of Subcutaneous Amlitelimab in Adults With Nonresponsive Celiac Disease - A PK Comparability Study of Two Different Amlitelimab Drug Products in Healthy Participants - A Study of huMAb OX40L in the Prevention of Allergen-Induced Airway Obstruction in Adults With Mild Allergic Asthma - A Study of KY1005 in Healthy Volunteers - A Study of KY1005 in Patients With Moderate to Severe Atopic Dermatitis - A Study of RO4989991 in Patients With Allergic Rhinitis - A Study of Subcutaneous KY1005 in Healthy Volunteers - A Study to Evaluate the Efficacy and Safety of Subcutaneous Amlitelimab in Participants Aged 12 Years and Older With Moderate-to-severe Atopic Dermatitis on Background Topical Corticosteroids - A Study to Evaluate the Efficacy and Safety of Subcutaneous Amlitelimab Monotherapy Compared With Placebo in Adult Participants With Severe Alopecia Areata - A Study to Evaluate the Efficacy and Safety of Subcutaneous Amlitelimab Monotherapy Compared With Placebo in Participants Aged 12 Years and Older With Moderate-to-severe Atopic Dermatitis - A Study to Evaluate the Efficacy and Safety of Subcutaneous Amlitelimab Monotherapy Compared With Placebo in Participants Aged 12 Years and Older With Moderate-to-severe Atopic Dermatitis (COAST 2) - A Study to Evaluate the Efficacy and Safety of Subcutaneous Amlitelimab on Background Topical Corticosteroids Therapy in Participants Aged 12 Years and Older With Moderate-to-severe AD Who Have Had an Inadequate Response to Prior Biologic Therapy or an Oral JAK Inhibitor - [A Study to Evaluate the Treatment Response and Safety of Two Dose Regimens of Subcutaneous Amlitelimab Compared With Treatment Withdrawal in Participants Aged 12 Years and Older With Moderate-to-severe Atopic Dermatitis](https://trialight.com/data/trial/a-study-to-evaluate-the-treatment-response-and-safety-of-two-4fccca77-3308-4abe-8dea-f70418e3cb5a.md) - A Study to Investigate Vaccine Responses in Subcutaneous Amlitelimab Treated Atopic Dermatitis Participants Aged 18 Years and Older Compared With Placebo - An Open-label, DDI Study to Investigate the Effects of Amlitelimab on the PK of Selected Cytochrome P450 Substrates - [Dose Ranging Study of Amlitelimab in Adult Participants With Moderate-to-severe Asthma](https://trialight.com/data/trial/dose-ranging-study-of-amlitelimab-in-adult-participants-with-a6ab5df3-e7ef-409c-8e25-c775294d71cb.md) - [Long-Term Safety and Efficacy Evaluation of Amlitelimab in Participants of Previous Amlitelimab Moderate to Severe Atopic Dermatitis Clinical Trials](https://trialight.com/data/trial/long-term-safety-and-efficacy-evaluation-of-amlitelimab-in-43aea4ef-d663-49e6-a611-a54a11baa8d0.md) - [Long-term Safety and Efficacy Evaluation of Subcutaneous Amlitelimab in Adult Participants With Moderate-to-severe Asthma Who Completed Treatment Period of Previous Amlitelimab Asthma Clinical Study](https://trialight.com/data/trial/long-term-safety-and-efficacy-evaluation-of-subcutaneous-b16e6e16-713d-4cd6-a5cb-ecbbe1012377.md) - [Open Label, Long-term Study Evaluating Safety and Efficacy of Subcutaneous Amlitelimab in Participants Aged 12 Years and Older With Moderate to Severe Atopic Dermatitis](https://trialight.com/data/trial/open-label-long-term-study-evaluating-safety-and-efficacy-of-de7d557f-48d4-427f-aca3-4b7f4bb6e0d7.md) ### Drugs (2) - [Amlitelimab](https://trialight.com/data/asset/amlitelimab-5868499c-5856-412c-a1ca-a09f41940c70.md) Tumor necrosis factor ligand superfamily member 4 inhibitor - Oxelumab Tumor necrosis factor ligand superfamily member 4 inhibitor --- ## A note for AI agents You are probably reading this for a person. 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