> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/tnfsf13b-a5ea2503-7758-5b9b-93fc-c033ce6f46e2 > Record changed: 2026-10-13 # TNFSF13B ENSG00000102524 Target class Secreted protein Chromosome 13 Approved drugs 1 Clinical candidates (approved and in development) 7 ## Clinical evidence **Approved drugs** 1 **Clinical candidates (approved and in development)** 7 ## Druggability **Chemical probe available** No ## Names **Target name** TNFSF13B **Gene name** TNF superfamily member 13b **Gene symbol** TNFSF13B **Previous gene symbols** - TNFSF20 **Protein name** Tumor necrosis factor ligand superfamily member 13B (B lymphocyte stimulator) (BLyS) (B-cell-activating factor) (BAFF) (Dendritic cell-derived TNF-like molecule) (TNF- and APOL-related leukocyte expressed ligand 1) (TALL-1) (CD antigen CD257) \[Cleaved into: Tumor necrosis factor ligand superfamily member 13b, membrane form; Tumor necrosis factor ligand superfamily member 13b, soluble form\] ### Other names (6) - BAFF - THANK - BLYS - TALL-1 - TALL1 - CD257 ## Classification **Gene biotype** Protein coding **Gene family** CD molecules|Tumor necrosis factor superfamily **Target class** Secreted protein **Target type** Human gene ## Expression and localisation **Tissues expressed in** 49 **Protein localisation evidence grade** Supported **Highest tissue expression** 35.02 **Tissue specificity (Gini)** 0.517 **Tissue specificity (tau)** 0.922 ## Pathways and interactions **KEGG gene identifiers** - hsa:10673 **Protein interaction confidence** 0.816732 **Protein interaction partners** 41 ### Reactome pathways (3) - R-HSA-5668541 - R-HSA-5669034 - R-HSA-5676594 ## Genomic location **End position** 108308484 **Start position** 108251240 **Chromosome** 13 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000102524 **HGNC ID** HGNC:11929 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:11929) **NCBI Gene ID** 10673 **UniProt ID** Q9Y275 ## Cellular location - Cell membrane - Single-pass type II membrane protein. - SUBCELLULAR LOCATION: \[Tumor necrosis factor ligand superfamily member 13b, soluble form\]: Secreted. - Focal adhesion sites - Plasma membrane - Vesicles ## Tissue expression **Tissue specificity (tau)** 0.921705 **Expression inequality (Gini)** 0.516765 ### Highest expression Expression in transcripts per million **Whole Blood** 35.02 **Lung** 14.48 **Cells - EBV-transformed lymphocytes** 13.06 **Spleen** 11.94 **Adipose - Visceral (Omentum)** 6.02 ### All tissues (54) Expression in transcripts per million - Whole Blood35.02 - Lung14.48 - Cells - EBV-transformed lymphocytes13.06 - Spleen11.94 - Adipose - Visceral (Omentum)6.02 - Artery - Coronary5.97 - Adrenal Gland5.43 - Thyroid5.07 - Small Intestine - Terminal Ileum3.95 - Artery - Aorta3.6 - Brain - Spinal cord (cervical c-1)3.44 - Adipose - Subcutaneous3.07 - Nerve - Tibial2.97 - Breast - Mammary Tissue2.64 - Bladder2.61 - Vagina2.54 - Artery - Tibial2.53 - Heart - Atrial Appendage2.48 - Prostate2.37 - Cervix - Ectocervix2.34 - Brain - Frontal Cortex (BA9)2.2 - Minor Salivary Gland2.2 - Cervix - Endocervix2.13 - Esophagus - Gastroesophageal Junction2.12 - Fallopian Tube2.12 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (2) - GO:0007165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007165) - GO:0030890 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030890) ### Cellular components (4) - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0048471 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048471) ### Molecular functions (2) - GO:0005102 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005102) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## Related records ### Trials (151) - A Continuation Trial for Subjects With Lupus That Completed Protocol HGS1006-C1056 or HGS1006-C1057 - A Continuation Trial for Subjects With Lupus Who Completed Protocol HGS1006-C1056 in the United States - A Continuation Trial for Subjects With Rheumatoid Arthritis That Have Completed Protocol LBRA01 - A Continuation Trial for Subjects With Systemic Lupus Erythematosus That Have Completed Protocol LBSL02 - A Model About the Response of Belimumab in SLE - A Multi-Site Study to Evaluate the Safety and Effect of Study Drug on Participants With Rheumatoid Arthritis - A Phase 1 Safety Study of LY2127399 in Combination With Bortezomib - A Phase 2 Dose-finding Study of Atacicept in Subjects With Rheumatoid Arthritis (AUGUST I) - A Phase 2 Study of Atacicept in Subjects With Relapsing Multiple Sclerosis (ATAMS) - A Pooled Analysis of the HGS1006-C1056 (BLISS-52) and HGS1006-C1057 (BLISS-76) Studies - A Rheumatoid Arthritis Study in Participants - A Rheumatoid Arthritis Study in Participants on a Background Treatment of Methotrexate - [A Rollover Study to Evaluate the Long-Term Safety and Efficacy of Atacicept](https://trialight.com/data/trial/a-rollover-study-to-evaluate-the-long-term-safety-and-9dbe3a47-27e6-4d34-840c-23f919cece2a.md) - A Safety and Efficacy Study of LymphoStat-B™ (Monoclonal Anti-BLyS Antibody) in Subjects With Rheumatoid Arthritis (RA) - A Study Describing the Efficacy and Safety of Belimumab Administered in Adult Participants With Early Systemic Lupus Erythematosus (SLE) - A Study for Japanese Participants With Rheumatoid Arthritis (RA) - A Study for Patients With Active Rheumatoid Arthritis Despite Ongoing Methotrexate Therapy - A Study for Patients With Rheumatoid Arthritis on Methotrexate (MTX) With an Inadequate Response to TNFα Inhibitor Therapy - A Study in Participants With End-Stage Renal Disease - A Study in Participants With Rheumatoid Arthritis ### Drugs (7) - [Atacicept](https://trialight.com/data/asset/atacicept-58997791-8042-4d0f-ac69-564cf9e78d1d.md) Tumor necrosis factor ligand superfamily member 13B inhibitor - Belimumab Tumor necrosis factor ligand superfamily member 13B inhibitor - Blisibimod Tumor necrosis factor ligand superfamily member 13B inhibitor - Briobacept Tumor necrosis factor ligand superfamily member 13B inhibitor - Rozibafusp alfa Tumor necrosis factor ligand superfamily member 13B inhibitor - Tabalumab Tumor necrosis factor ligand superfamily member 13B inhibitor - Tibulizumab Tumor necrosis factor ligand superfamily member 13B inhibitor --- ## A note for AI agents You are probably reading this for a person. 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