> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/tnfsf13-45f49145-416e-5e16-b03b-b1de0275c8c9 > Record changed: 2026-10-13 # TNFSF13 ENSG00000161955 Target class Secreted protein Chromosome 17 Approved drugs 0 Clinical candidates (approved and in development) 2 ## Clinical evidence **Approved drugs** 0 **ClinGen gene-disease validity** Limited **Clinical candidates (approved and in development)** 2 ## Druggability **Chemical probe available** No ## Names **Target name** TNFSF13 **Gene name** TNF superfamily member 13 **Gene symbol** TNFSF13 **Protein name** Tumor necrosis factor ligand superfamily member 13 (A proliferation-inducing ligand) (APRIL) (TNF- and APOL-related leukocyte expressed ligand 2) (TALL-2) (TNF-related death ligand 1) (TRDL-1) (CD antigen CD256) ### Other names (2) - APRIL - CD256 ## Classification **Gene biotype** Protein coding **Gene family** CD molecules|Tumor necrosis factor superfamily **Target class** Secreted protein **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Highest tissue expression** 96.18 **Tissue specificity (Gini)** 0.307 **Tissue specificity (tau)** 0.68 ## Pathways and interactions **KEGG gene identifiers** - hsa:8741 **Protein interaction confidence** 0.8762 **Protein interaction partners** 10 ### Reactome pathways (2) - R-HSA-450520 - R-HSA-5669034 ## Genomic location **End position** 7561608 **Start position** 7558292 **Chromosome** 17 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000161955 **HGNC ID** HGNC:11928 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:11928) **NCBI Gene ID** 8741 **UniProt ID** O75888 ## Cellular location - Secreted . ### Publication evidence - PubMed 11571266 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/11571266/) ## Tissue expression **Tissue specificity (tau)** 0.680132 **Expression inequality (Gini)** 0.307294 ### Highest expression Expression in transcripts per million **Lung** 96.18 **Minor Salivary Gland** 85.13 **Kidney - Medulla** 68.45 **Nerve - Tibial** 60.09 **Artery - Aorta** 55.05 ### All tissues (54) Expression in transcripts per million - Lung96.18 - Minor Salivary Gland85.13 - Kidney - Medulla68.45 - Nerve - Tibial60.09 - Artery - Aorta55.05 - Whole Blood50.42 - Thyroid49.78 - Spleen49.56 - Ovary45.72 - Fallopian Tube45 - Cervix - Endocervix44.89 - Kidney - Cortex42.25 - Stomach41.62 - Artery - Coronary40.7 - Colon - Transverse40.38 - Brain - Caudate (basal ganglia)39.67 - Adipose - Visceral (Omentum)39.3 - Prostate38.85 - Brain - Nucleus accumbens (basal ganglia)37.38 - Cervix - Ectocervix35.23 - Adrenal Gland34.29 - Brain - Putamen (basal ganglia)32.94 - Small Intestine - Terminal Ileum31.97 - Brain - Cortex31.58 - Breast - Mammary Tissue31.11 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (3) - GO:0007165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007165) - GO:0008284 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008284) - GO:0048298 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048298) ### Cellular components (5) - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) - GO:0005654 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005654) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0070062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062) ### Molecular functions (2) - GO:0005102 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005102) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## Related records ### Trials (26) - A Phase 2 Dose-finding Study of Atacicept in Subjects With Rheumatoid Arthritis (AUGUST I) - A Phase 2 Study of Atacicept in Subjects With Relapsing Multiple Sclerosis (ATAMS) - [A Rollover Study to Evaluate the Long-Term Safety and Efficacy of Atacicept](https://trialight.com/data/trial/a-rollover-study-to-evaluate-the-long-term-safety-and-9dbe3a47-27e6-4d34-840c-23f919cece2a.md) - A Trial to Evaluate the Efficacy and Safety of Sibeprenlimab Administered Subcutaneously in Participants With Sjögren's - Atacicept Demonstrating Dose RESponSe - Atacicept in Anti-Tumor Necrosis Factor Alpha-naïve Subjects With Rheumatoid Arthritis (AUGUST II) - Atacicept in Combination With Rituximab in Subjects With Rheumatoid Arthritis (August III) - Atacicept in Lupus Nephritis Patients Taking Stable Regimen of Mycophenolate Mofetil - Atacicept in Multiple Glomerular Diseases - Atacicept in Multiple Sclerosis Extension Study, Phase II - Atacicept in Subjects With Active Lupus Nephritis (COMPASS) - Atacicept in Subjects With IgA Nephropathy - Atacicept in Subjects With Optic Neuritis - Atacicept Phase 2/3 in Generalized Systemic Lupus Erythematosus (APRIL-SLE) - CD24Fc for the Treatment of Immune Related Adverse Events in Patients With Advanced Solid Tumors, TIRAEC Study - Efficacy and Safety of Atacicept in IgA Nephropathy - Efficacy and Safety of Atacicept in Systemic Lupus Erythematosus - First in Human Study to Assess Safety of VIS649 in Healthy Subjects - Long-term Safety and Tolerability of Atacicept (Long-term Follow-Up of Participant Who Participated in ADDRESS II) - Monthly Dosing of Atacicept in IgAN ### Drugs (2) - [Atacicept](https://trialight.com/data/asset/atacicept-58997791-8042-4d0f-ac69-564cf9e78d1d.md) Tumor necrosis factor ligand superfamily member 13 inhibitor - Sibeprenlimab Tumor necrosis factor ligand superfamily member 13 inhibitor --- ## A note for AI agents You are probably reading this for a person. 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