> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/tnfsf11-f943913e-58f0-5f3e-b943-025022f2eab3
> Record changed: 2026-10-13

# TNFSF11

ENSG00000120659

Target class

Secreted protein

Chromosome

13

Approved drugs

1

Clinical candidates (approved and in development)

1

## Clinical evidence

**Approved drugs**

1

**ClinGen gene-disease validity**

Definitive

**Clinical candidates (approved and in development)**

1

## Druggability

**Chemical probe available**

No

## Names

**Target name**

TNFSF11

**Gene name**

TNF superfamily member 11

**Gene symbol**

TNFSF11

**Protein name**

Tumor necrosis factor ligand superfamily member 11 (Osteoclast differentiation factor) (ODF) (Osteoprotegerin ligand) (OPGL) (Receptor activator of nuclear factor kappa-B ligand) (RANKL) (TNF-related activation-induced cytokine) (TRANCE) (CD antigen CD254) \[Cleaved into: Tumor necrosis factor ligand superfamily member 11, membrane form; Tumor necrosis factor ligand superfamily member 11, soluble form\]

### Other names (5)

- TRANCE
- RANKL
- OPGL
- ODF
- CD254

## Classification

**Gene biotype**

Protein coding

**Gene family**

CD molecules|Tumor necrosis factor superfamily

**Target class**

Secreted protein

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

2

**Highest tissue expression**

14.71

**Tissue specificity (Gini)**

0.931

**Tissue specificity (tau)**

0.994

## Pathways and interactions

**KEGG gene identifiers**

- hsa:8600

**Protein interaction confidence**

0.820407

**Protein interaction partners**

54

### Reactome pathways (4)

- R-HSA-5668541
- R-HSA-5669034
- R-HSA-5676594
- R-HSA-9856649

## Genomic location

**End position**

42608013

**Start position**

42562736

**Chromosome**

13

**Strand**

Forward

## Identifiers

**Ensembl gene ID**

ENSG00000120659

**HGNC ID**

HGNC:11926

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:11926)

**NCBI Gene ID**

8600

**UniProt ID**

O14788

## Cellular location

- \[Isoform 1\]: Cell membrane
- Single-pass type II membrane protein.
- SUBCELLULAR LOCATION: \[Isoform 3\]: Cell membrane
- Single-pass type II membrane protein.
- SUBCELLULAR LOCATION: \[Isoform 2\]: Cytoplasm .
- SUBCELLULAR LOCATION: \[Tumor necrosis factor ligand superfamily member 11, soluble form\]: Secreted .

## Tissue expression

**Tissue specificity (tau)**

0.994331

**Expression inequality (Gini)**

0.930776

### Highest expression

Expression in transcripts per million

**Cells - EBV-transformed lymphocytes**

14.71

**Testis**

1.66

**Small Intestine - Terminal Ileum**

0.62

**Liver**

0.34

**Spleen**

0.23

### All tissues (54)

Expression in transcripts per million

- Cells - EBV-transformed lymphocytes14.71
- Testis1.66
- Small Intestine - Terminal Ileum0.62
- Liver0.34
- Spleen0.23
- Minor Salivary Gland0.16
- Colon - Transverse0.16
- Esophagus - Mucosa0.11
- Skin - Not Sun Exposed (Suprapubic)0.11
- Vagina0.09
- Adipose - Visceral (Omentum)0.08
- Brain - Hypothalamus0.08
- Lung0.06
- Kidney - Cortex0.06
- Pituitary0.06
- Skin - Sun Exposed (Lower leg)0.05
- Bladder0.05
- Artery - Coronary0.05
- Pancreas0.04
- Esophagus - Muscularis0.04
- Artery - Tibial0.04
- Thyroid0.04
- Colon - Sigmoid0.04
- Prostate0.04
- Breast - Mammary Tissue0.03

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (13)

- GO:0002548  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002548)
- GO:0019221  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019221)
- GO:0030316  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030316)
- GO:0033209  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0033209)
- GO:0034112  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034112)
- GO:0043410  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043410)
- GO:0045672  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045672)
- GO:0045780  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045780)
- GO:0045944  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045944)
- GO:0050870  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050870)
- GO:0070374  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070374)
- GO:1901224  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1901224)
- GO:1902533  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1902533)

### Cellular components (2)

- GO:0005576  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576)
- GO:0005886  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886)

### Molecular functions (2)

- GO:0005125  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005125)
- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)

## Related records

### Trials (284)

- 4-weekly Versus 12-weekly Administration of Bone-targeted Agents in Patients With Bone Metastases
- A Clinical Study Evaluating the Dermal Safety of Soluble Denosumab Microneedle Patches
- A Comparative Study to Valuating the Efficacy and Safety of QL1206 and Prolia®
- A Double-blind Study to Assess the Efficacy and Safety of Denosumab Produced by Two Different Processes in Postmenopausal Women With Osteoporosis
- A High-resolution Peripheral Quantitative Computed Tomography Study in Postmenopausal Women Previously Treated With Denosumab
- A Multi-Center, Randomized, Open-Label Study to Assess the Immunogenicity and Safety of Denosumab in Pre-filled Syringe Compared to Vial in Subjects With Low Bone Mineral Density
- A Multicenter, Randomized Placebo Controlled Pilot MicroCT Study to Estimate the Effect of Treatment With Denosumab (AMG 162) and Alendronate Sodium in Postmenopausal Women With Low Bone Mineral Density
- A Pharmacokinetic Similarity Study in Healthy Male Subjects to Evaluate Pharmacokinetics, Pharmacodynamics, Safety and Immunogenicity of LY06006 Versus US-Prolia and EU-Prolia by Single-dose Subcutaneous Injection
- A Phase 3 Study to Compare Between CT-P41 and US-licensed Prolia in Postmenopausal Women With Osteoporosis
- A Phase 3 Study to Compare Biosimilar Denosumab With Prolia®
- A Phase I Study to Evaluate the Safety and Pharmacokinetics of CT-P41 and EU-approved Prolia in Healthy Male Subjects
- A Randomized, Double-Blind Study to Compare the Efficacy of Treatment With Denosumab Versus Alendronate Sodium in Postmenopausal Women With Low Bone Mineral Density.
- A Randomized, Double-blind, Placebo-controlled, Dose Response Study of AMG 162 (Denosumab) in Japanese Postmenopausal Osteoporotic Subjects
- A Real-world Study on Patients of Unresectable Giant Cell Tumor of Bone
- A Study Comparing Denosumab vs. Zoledronic Acid for the Treatment of Bone Metastases in Breast Cancer Subjects.
- [A Study Comparing the Pharmacokinetic Similarity of MB09 and EU/US-Sourced Xgeva](https://trialight.com/data/trial/a-study-comparing-the-pharmacokinetic-similarity-of-mb09-and-24ea61a5-9188-47c7-97e2-c8785c96d0d6.md)
- A Study Evaluating the Efficacy of PD-1 Inhibitor Combined With Denosumab and Chemotherapy in Locally Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer Patients With Driver Gene-Negative Status
- A Study for the Evaluation of Efficacy and Safety of Prolia® in Participants With Glucocorticoid-induced Osteoporosis in Mainland China
- A Study in Indian Postmenopausal Women With Osteoporosis to Evaluate the Efficacy and Safety of Denosumab
- A Study in Korean Postmenopausal Women With Osteoporosis to Evaluate the Efficacy and Safety of Denosumab

### Drugs (1)

- [Denosumab](https://trialight.com/data/asset/denosumab-9ee8731d-42aa-4d04-abbd-9dffa084523f.md) Tumor necrosis factor ligand superfamily member 11 inhibitor

---

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