> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/tnfrsf8-ea5051a6-2140-593b-8c7d-ffc4c956dc5d > Record changed: 2026-10-13 # TNFRSF8 ENSG00000120949 Target class Secreted protein Chromosome 1 Approved drugs 1 Clinical candidates (approved and in development) 4 ## Clinical evidence **Approved drugs** 1 **Clinical candidates (approved and in development)** 4 ## Druggability **Chemical probe available** No ## Names **Other names** - KI-1 **Target name** TNFRSF8 **Gene name** TNF receptor superfamily member 8 **Gene symbol** TNFRSF8 **Protein name** Tumor necrosis factor receptor superfamily member 8 (CD30L receptor) (Ki-1 antigen) (Lymphocyte activation antigen CD30) (CD antigen CD30) ### Previous gene symbols (2) - CD30 - D1S166E ## Classification **Gene biotype** Protein coding **Gene family** CD molecules|Tumor necrosis factor receptor superfamily **Target class** Secreted protein **Target type** Human gene ## Expression and localisation **Tissues expressed in** 18 **Protein localisation evidence grade** Supported **Highest tissue expression** 90.13 **Tissue specificity (Gini)** 0.831 **Tissue specificity (tau)** 0.988 ## Pathways and interactions **KEGG gene identifiers** - hsa:943 **Reactome pathways** - R-HSA-5669034 **Protein interaction confidence** 0.821718 **Protein interaction partners** 39 ## Genomic location **End position** 12144207 **Start position** 12063303 **Chromosome** 1 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000120949 **HGNC ID** HGNC:11923 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:11923) **NCBI Gene ID** 943 **UniProt ID** P28908 ## Cellular location - \[Isoform 1\]: Cell membrane - Single-pass type I membrane protein . - SUBCELLULAR LOCATION: \[Isoform 2\]: Cytoplasm . - Plasma membrane ### Publication evidence (3) - PubMed 8391931 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/8391931/) - PubMed 8999898 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/8999898/) - PubMed 8839832 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/8839832/) ## Tissue expression **Tissue specificity (tau)** 0.988375 **Expression inequality (Gini)** 0.831353 ### Highest expression Expression in transcripts per million **Cells - EBV-transformed lymphocytes** 90.13 **Adipose - Subcutaneous** 6.59 **Adipose - Visceral (Omentum)** 5.53 **Whole Blood** 4.84 **Breast - Mammary Tissue** 4.05 ### All tissues (54) Expression in transcripts per million - Cells - EBV-transformed lymphocytes90.13 - Adipose - Subcutaneous6.59 - Adipose - Visceral (Omentum)5.53 - Whole Blood4.84 - Breast - Mammary Tissue4.05 - Testis3.94 - Brain - Nucleus accumbens (basal ganglia)2.65 - Nerve - Tibial2.08 - Brain - Caudate (basal ganglia)1.98 - Spleen1.93 - Brain - Putamen (basal ganglia)1.67 - Fallopian Tube1.27 - Uterus1.25 - Heart - Atrial Appendage1.23 - Skin - Sun Exposed (Lower leg)1.17 - Lung1.12 - Artery - Coronary1.07 - Esophagus - Muscularis1.01 - Esophagus - Gastroesophageal Junction0.99 - Stomach0.98 - Small Intestine - Terminal Ileum0.83 - Bladder0.76 - Skin - Not Sun Exposed (Suprapubic)0.76 - Artery - Tibial0.71 - Colon - Sigmoid0.63 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (6) - GO:0007165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007165) - GO:0008285 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008285) - GO:0032759 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032759) - GO:0032760 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032760) - GO:0043065 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043065) - GO:0071260 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071260) ### Cellular components (3) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0070062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062) ### Molecular functions (3) - GO:0002020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002020) - GO:0004888 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004888) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## Related records ### Trials (199) - A Brentuximab Vedotin Trial for Patients Who Have Previously Participated in a Brentuximab Vedotin Study - A Clinical Trial of Quadrivalent Influenza Vaccine in Healthy Subjects Aged 6 to 35 Months - A Comparative Study on Local Allergic Responses of Bee Venom and Essential Bee Venom Pharmacopuncture - A Frontline Therapy Trial in Participants With Advanced Classical Hodgkin Lymphoma - A Phase 1 Study in Patients With Relapsed or Refractory Hodgkin Lymphoma or Systemic Anaplastic Large Cell Lymphoma - A Phase 1 Study of Brentuximab Vedotin Combined With Multi-Agent Chemotherapy for Hodgkin Lymphoma - A Phase 1 Study of Brentuximab Vedotin Given Sequentially and Combined With Multi-Agent Chemotherapy for CD30-Positive Mature T-Cell and NK-Cell Neoplasms - A Phase 2 Open Label Trial of Brentuximab Vedotin (SGN-35) for Systemic Anaplastic Large Cell Lymphoma - A Phase 3 Study of Brentuximab Vedotin (SGN-35) in Patients at High Risk of Residual Hodgkin Lymphoma Following Stem Cell Transplant (The AETHERA Trial) - A Phase 3 Trial of Brentuximab Vedotin(SGN-35) Versus Physician's Choice (Methotrexate or Bexarotene) in Participants With CD30-Positive Cutaneous T-Cell Lymphoma (ALCANZA Study) - A Phase I Dose Escalation Study of SGN-35 Alone and in Combination With Gemcitabine for CD30-Positive Malignancies - A Phase II Study of MDX-060 in Subjects With Relapsed or Refractory Hodgkin's Disease - A Phase II Study of Single Agent Brentuximab Vedotin in Relapsed/Refractory CD30 Low (<10%) Mature T Cell Lymphoma (TCL) - [A Phase III Clinical Trial of Quadrivalent Influenza Vaccine in Healthy Subjects Aged 6 to 35 Months](https://trialight.com/data/trial/a-phase-iii-clinical-trial-of-quadrivalent-influenza-vaccine-03a7e93e-7961-4a78-91a9-6a671e95dece.md) - A Pivotal Open-Label Trial of Brentuximab Vedotin for Hodgkin Lymphoma - A Risk Stratified Sequential Treatment With Rituximab, Brentuximab Vedotin and Bendamustine (RBvB) - A Safety Study of Brentuximab Vedotin in Participants With HIV - A Safety Study of SEA-TGT (SGN-TGT) in Advanced Cancer - A Safety/Efficacy Study of SGN-30 (Antibody) in Patients With Refractory or Recurrent CD30+ Hematologic Malignancies - A Study of Brentuximab Vedotin + Adriamycin, Vinblastine, and Dacarbazine in Pediatric Participants With Advanced Stage Newly Diagnosed Hodgkin Lymphoma ### Drugs (4) - [Brentuximab vedotin](https://trialight.com/data/asset/brentuximab-vedotin-b112eac4-7573-41dc-af6c-6c9212132a79.md) Tumor necrosis factor receptor superfamily member 8 binding agent - HEFI-1 Tumor necrosis factor receptor superfamily member 8 binding agent - Iratumumab Tumor necrosis factor receptor superfamily member 8 other - SGN-30 Tumor necrosis factor receptor superfamily member 8 agonist --- ## A note for AI agents You are probably reading this for a person. 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