> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/tnfrsf4-fdff5b48-82cf-5f37-a19d-e2224f51dcd2 > Record changed: 2026-10-13 # TNFRSF4 ENSG00000186827 Target class Membrane receptor Chromosome 1 Approved drugs 0 Clinical candidates (approved and in development) 5 ## Clinical evidence **Approved drugs** 0 **ClinGen gene-disease validity** Limited **Clinical candidates (approved and in development)** 5 ## Druggability **Chemical probe available** No ## Names **Target name** TNFRSF4 **Gene name** TNF receptor superfamily member 4 **Gene symbol** TNFRSF4 **Previous gene symbols** - TXGP1L **Protein name** Tumor necrosis factor receptor superfamily member 4 (ACT35 antigen) (OX40L receptor) (TAX transcriptionally-activated glycoprotein 1 receptor) (CD antigen CD134) ### Other names (3) - ACT35 - OX40 - CD134 ## Classification **Gene biotype** Protein coding **Gene family** CD molecules|Tumor necrosis factor receptor superfamily **Target class** Membrane receptor **Target type** Human gene ## Expression and localisation **Tissues expressed in** 41 **Highest tissue expression** 23.23 **Tissue specificity (Gini)** 0.531 **Tissue specificity (tau)** 0.861 ## Pathways and interactions **KEGG gene identifiers** - hsa:7293 **Reactome pathways** - R-HSA-5669034 **Protein interaction confidence** 0.853538 **Protein interaction partners** 39 ## Genomic location **End position** 1214153 **Start position** 1211326 **Chromosome** 1 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000186827 **HGNC ID** HGNC:11918 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:11918) **NCBI Gene ID** 7293 **UniProt ID** P43489 ## Cellular location - Membrane - Single-pass type I membrane protein. ## Tissue expression **Tissue specificity (tau)** 0.860931 **Expression inequality (Gini)** 0.531283 ### Highest expression Expression in transcripts per million **Spleen** 23.23 **Adipose - Visceral (Omentum)** 15.26 **Lung** 13.85 **Cells - EBV-transformed lymphocytes** 11 **Thyroid** 9.95 ### All tissues (54) Expression in transcripts per million - Spleen23.23 - Adipose - Visceral (Omentum)15.26 - Lung13.85 - Cells - EBV-transformed lymphocytes11 - Thyroid9.95 - Breast - Mammary Tissue9.48 - Adipose - Subcutaneous9.24 - Small Intestine - Terminal Ileum7.26 - Prostate6.22 - Whole Blood5.46 - Colon - Transverse4.55 - Kidney - Medulla4.3 - Cervix - Endocervix4.08 - Bladder3.83 - Cervix - Ectocervix3.41 - Fallopian Tube3.2 - Heart - Left Ventricle3.18 - Pituitary3.08 - Uterus3.07 - Artery - Coronary2.92 - Stomach2.75 - Minor Salivary Gland2.68 - Artery - Aorta2.57 - Heart - Atrial Appendage2.54 - Nerve - Tibial2.41 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes - GO:0006955 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006955) ### Cellular components - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) ### Molecular functions (2) - GO:0005031 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005031) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## Related records ### Trials (35) - A Phase 1 Study of KHK4083 in Healthy Volunteers and Subjects With Ulcerative Colitis - A Phase 1 Study of KHK4083 in Subjects With Atopic Dermatitis - A Phase 1b/2 Safety and Tolerability Study of MEDI6469 in Combination With Therapeutic Immune Agents or Monoclonal Antibodies - [A Phase 2, Dose Ranging Study Assessing Rocatinlimab in Moderate-to-severe Asthma](https://trialight.com/data/trial/a-phase-2-dose-ranging-study-assessing-rocatinlimab-in-615ff7dd-ab2f-42ca-8386-b1206a1e395d.md) - A Phase 3, Placebo-controlled, Double-blind Study Assessing Rocatinlimab in Prurigo Nodularis - A Study Assessing Rocatinlimab (AMG 451) Monotherapy in Moderate-to-severe Atopic Dermatitis (AD) (ROCKET-Horizon) - A Study Assessing Rocatinlimab in Combination With Topical Corticosteroid and/or Topical Calcineurin Inhibitors in Adult Participants With Moderate-to-severe Atopic Dermatitis (AD) - A Study Assessing Rocatinlimab on Vaccine Antibody Response in Moderate-to-severe Atopic Dermatitis (AD) (ROCKET - VOYAGER) - A Study Evaluating Rocatinlimab in Moderate-to-severe Atopic Dermatitis (ROCKET-IGNITE) - A Study Of Avelumab In Combination With Other Cancer Immunotherapies In Advanced Malignancies (JAVELIN Medley) - [A Study to Assess Bioavailability of Rocatinlimab (AMG 451) Vial and Prefilled Syringe in Healthy Participants](https://trialight.com/data/trial/a-study-to-assess-bioavailability-of-rocatinlimab-amg-451-c8bc78eb-da01-4d0a-8a15-2dbe4b3afbb2.md) - [A Study to Assess Long-term Safety, Tolerability, and Efficacy of Rocatinlimab in Adult and Adolescent Participants With Moderate-to-severe Atopic Dermatitis (AD)](https://trialight.com/data/trial/a-study-to-assess-long-term-safety-tolerability-and-efficacy-dfc85d4b-ab75-4b37-b341-39807e17c225.md) - A Study to Assess the Safety, Tolerability, and Efficacy of Rocatinlimab in Adolescent Participants With Moderate-to-severe Atopic Dermatitis (AD) - [A Study to Evaluate Bioavailability of Rocatinlimab Autoinjector and Vial in Healthy Participants](https://trialight.com/data/trial/a-study-to-evaluate-bioavailability-of-rocatinlimab-138d16e4-b2fa-4b12-8d43-a9f68ca520fc.md) - A Study to Evaluate Rocatinlimab (AMG 451) in Adolescent Participants With Moderate-to-severe Atopic Dermatitis (AD) - A Study to Evaluate Rocatinlimab (AMG 451) in Healthy Chinese Participants - A Study With Self-administered Rocatinlimab in Adolescent and Adult Participants With Moderate-to-severe Atopic Dermatitis - Anti-OX40 Antibody (MEDI6469) in Patients With Metastatic Colorectal Cancer - Avelumab With Binimetinib, Sacituzumab Govitecan, or Liposomal Doxorubicin in Treating Stage IV or Unresectable, Recurrent Triple Negative Breast Cancer - Avelumab, Utomilumab, Anti-OX40 Antibody PF-04518600, and Radiation Therapy in Treating Patients With Advanced Malignancies ### Drugs (5) - GSK-3174998 Tumor necrosis factor receptor superfamily member 4 agonist - Ivuxolimab Tumor necrosis factor receptor superfamily member 4 agonist - MEDI-6469 Tumor necrosis factor receptor superfamily member 4 agonist - [Rocatinlimab](https://trialight.com/data/asset/rocatinlimab-62634da9-46fe-4969-8859-264ab7ebf719.md) Tumor necrosis factor receptor superfamily member 4 antagonist - Telazorlimab Tumor necrosis factor receptor superfamily member 4 antagonist --- ## A note for AI agents You are probably reading this for a person. 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