> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/tnf-4a9ed8f4-ec49-59e1-846e-4364b7f50d07 > Record changed: 2026-10-13 # TNF ENSG00000232810 Target class Secreted protein Chromosome 6 Approved drugs 5 Clinical candidates (approved and in development) 15 ## Clinical evidence **Approved drugs** 5 **Clinical candidates (approved and in development)** 15 ## Druggability **Chemical probe available** Yes ## Names **Target name** TNF **Gene name** Tumor necrosis factor **Gene symbol** TNF **Previous gene symbols** - TNFA **Protein name** Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) \[Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form\] ### Other names (3) - TNFSF2 - DIF - TNF-alpha ## Classification **Gene biotype** Protein coding **Gene family** Tumor necrosis factor superfamily **Target class** Secreted protein **Target type** Human gene ## Expression and localisation **Tissues expressed in** 8 **Highest tissue expression** 133.01 **Tissue specificity (Gini)** 0.908 **Tissue specificity (tau)** 0.995 ## Pathways and interactions **KEGG gene identifiers** - hsa:7124 **Protein interaction confidence** 0.830395 **Protein interaction partners** 380 ### Reactome pathways (10) - R-HSA-381340 - R-HSA-5357786 - R-HSA-5357905 - R-HSA-5357956 - R-HSA-5626978 - R-HSA-5668541 - R-HSA-6783783 - R-HSA-6785807 - R-HSA-75893 - R-HSA-9942503 ## Genomic location **End position** 31578336 **Start position** 31575565 **Chromosome** 6 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000232810 **HGNC ID** HGNC:11892 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:11892) **NCBI Gene ID** 7124 **UniProt ID** P01375 ## Cellular location - Cell membrane - Single-pass type II membrane protein . - SUBCELLULAR LOCATION: \[Tumor necrosis factor, membrane form\]: Membrane - Single-pass type II membrane protein. - SUBCELLULAR LOCATION: \[Tumor necrosis factor, soluble form\]: Secreted . - SUBCELLULAR LOCATION: \[C-domain 1\]: Secreted. - SUBCELLULAR LOCATION: \[C-domain 2\]: Secreted. ### Publication evidence (2) - PubMed 16829952 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/16829952/) - PubMed 23552949 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23552949/) ## Tissue expression **Tissue specificity (tau)** 0.994976 **Expression inequality (Gini)** 0.907627 ### Highest expression Expression in transcripts per million **Cells - EBV-transformed lymphocytes** 133.01 **Spleen** 8.96 **Whole Blood** 4.57 **Lung** 2.68 **Small Intestine - Terminal Ileum** 2.02 ### All tissues (54) Expression in transcripts per million - Cells - EBV-transformed lymphocytes133.01 - Spleen8.96 - Whole Blood4.57 - Lung2.68 - Small Intestine - Terminal Ileum2.02 - Skin - Not Sun Exposed (Suprapubic)1.68 - Skin - Sun Exposed (Lower leg)1.23 - Adipose - Visceral (Omentum)1.06 - Kidney - Medulla0.86 - Kidney - Cortex0.86 - Colon - Transverse0.76 - Adrenal Gland0.74 - Esophagus - Mucosa0.7 - Artery - Coronary0.54 - Artery - Aorta0.54 - Breast - Mammary Tissue0.52 - Colon - Sigmoid0.5 - Fallopian Tube0.45 - Heart - Left Ventricle0.43 - Esophagus - Muscularis0.4 - Stomach0.39 - Minor Salivary Gland0.35 - Heart - Atrial Appendage0.34 - Esophagus - Gastroesophageal Junction0.33 - Liver0.3 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (78) - GO:0000122 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000122) - GO:0001819 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001819) - GO:0002439 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002439) - GO:0002719 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002719) - GO:0006954 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006954) - GO:0008625 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008625) - GO:0009615 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009615) - GO:0009651 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009651) - GO:0010573 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010573) - GO:0010628 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010628) - GO:0010629 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010629) - GO:0010744 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010744) - GO:0031334 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031334) - GO:0032715 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032715) - GO:0032722 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032722) - GO:0032731 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032731) - GO:0032755 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032755) - GO:0032757 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032757) - GO:0033209 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0033209) - GO:0034116 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034116) - GO:0043065 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043065) - GO:0043068 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043068) - GO:0043122 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043122) - GO:0043123 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043123) - GO:0043243 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043243) And 53 more, listed on the interactive page. ### Cellular components (4) - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0009986 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009986) - GO:0045121 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045121) ### Molecular functions (6) - GO:0000976 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000976) - GO:0002020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002020) - GO:0005125 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005125) - GO:0005164 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005164) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0042802 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042802) ## Off-target safety - regulation of gene expression ### Studies - cell-based: BSK\_LPS\_TNFa, is one of 11 assay component(s) measured or calculated from the BSK\_LPS assay. It is designed to make measurements of enzyme-linked immunosorbent assay, a form of binding reporter, as detected with fluorescence intensity signals by Enzyme-linked immunosorbent assay technology. ### Biological samples - umbilical vein endothelium and peripheral blood mononuclear cells, primary cell co-culture Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) ## Related records ### Trials (1,601) - "Comparison of the Efficacy and Safety of Adalimumab to That of Tocilizumab in Severe Uveitis of Behçet's Disease" - "Efficacy and Safety of Infliximab-biosimilar (Inflectra) Compared to Infliximab-innovator (Remicade) in Patients With Inflammatory Bowel Disease in Remission: the SIMILAR Trial" - 12-Week Study Evaluating the Efficacy, Safety, and Tolerability of Adjunctive Infliximab for Bipolar I/II Depression - 16.0040 Ankylosing Spondylitis Study - 2 Regimens of Lactulose for Colonoscopy Preparation in Adults - 3D Evaluation of Postoperative Edema After Third Molar Surgery - A 12 Week Study to Assess Changes in Joint Inflammation Using Ultrasonography in Patients With Rheumatoid Arthritis (RA) - A 12-week Study to Compare the Efficacy and Safety of Fixed Combinations of Fenofibrate/Simvastatin 145/20mg and Fenofibrate/Simvastatin 145/40mg Tablets Versus Fenofibrate or Simvastatin Monotherapies in Subjects With Abnormal Blood Levels of Fats (Lipids) and at High Risk of Cardiovascular Disease - A 24 Week Open Label Study of the Utility of Adalimumab in Active Axial Forms of Psoriatic Arthritis - A 3-arm Multi-center, Randomized Controlled Study Comparing Transforaminal Corticosteroid, Transforaminal Etanercept and Transforaminal Saline for Lumbosacral Radiculopathy - A 6-month Randomised, Double-blind, Open Arm Comparator, Phase IIb, With AZD9056, in Patients With Rheumatoid Arthritis (RA) - A 6-Months Infliximab Or Placebo Study In UA At High Risk Of RA:Clinical,Radiological And Synovial Benefit - A Bioequivalence Study of Two Different Formulations of Olmesartan Medoxomil/ Hydrochlorothiazide After a Single Oral Dose Administration Under Fasting Conditions - A Canadian Open-Label Access Program to Evaluate Adalimumab When Added to Inadequate Therapy for the Treatment of Psoriasis - A Canadian Open-Label Study to Evaluate the Safety and Effectiveness of Adalimumab When Added to Inadequate Therapy for the Treatment of Psoriatic Arthritis (PsA) (ACCLAIM) - A Canadian Study to Evaluate Early Use of Adalimumab After Methotrexate Failure in Early Rheumatoid Arthritis - A Clinical Study of Increased Dose of TA-650 in Patients With Psoriasis - [A Clinical Study With Adalimumab Biosimilar](https://trialight.com/data/trial/a-clinical-study-with-adalimumab-biosimilar-cd7edfca-24b4-4978-adef-90c81709e325.md) - A Clinical Trail of Adalimumab in Treating Chinese Children With Severe Plaque Psoriasis - A Clinical Trial Evaluating the Safety and Effectiveness of Golimumab in Patients With Severe, Persistent Asthma ### Drugs (15) - ABBV-3373 TNF-alpha binding agent - [Adalimumab](https://trialight.com/data/asset/adalimumab-77d73b6e-cb34-48b5-9716-a71bee4e5e02.md) TNF-alpha inhibitor - Afelimomab TNF-alpha inhibitor - AZ9773 TNF-alpha inhibitor - Certolizumab pegol TNF-alpha inhibitor - [Etanercept](https://trialight.com/data/asset/etanercept-b317b90d-f8fa-4b94-a6a2-12f14534f4a1.md) TNF-alpha inhibitor - [Golimumab](https://trialight.com/data/asset/golimumab-029e0cce-9d8f-4121-b835-6c4aa307913c.md) TNF-alpha inhibitor - [Infliximab](https://trialight.com/data/asset/infliximab-4ac1099c-60c4-4b24-80f5-85ddb5503b21.md) TNF-alpha inhibitor - Lenercept TNF-alpha inhibitor - Nerelimomab TNF-alpha inhibitor - Onercept TNF-alpha inhibitor - Ozoralizumab TNF-alpha inhibitor - Pegsunercept TNF-alpha inhibitor - Placulumab TNF-alpha inhibitor - Remtolumab TNF-alpha inhibitor --- ## A note for AI agents You are probably reading this for a person. 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