> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/tlr9-44bcb4f7-bea0-55ea-b4de-03f1b54cebeb > Record changed: 2026-10-13 # TLR9 ENSG00000239732 Target class Membrane receptor Chromosome 3 Approved drugs 1 Clinical candidates (approved and in development) 9 ## Clinical evidence **Approved drugs** 1 **Clinical candidates (approved and in development)** 9 ## Druggability **Chemical probe available** Yes ## Names **Other names** - CD289 **Target name** TLR9 **Gene name** Toll like receptor 9 **Gene symbol** TLR9 **Protein name** Toll-like receptor 9 (CD antigen CD289) ## Classification **Gene biotype** Protein coding **Gene family** CD molecules|Toll like receptors|My-T-BRC complex **Target class** Membrane receptor **Target type** Human gene ## Expression and localisation **Tissues expressed in** 29 **Highest tissue expression** 13.1 **Tissue specificity (Gini)** 0.515 **Tissue specificity (tau)** 0.877 ## Pathways and interactions **KEGG gene identifiers** - hsa:54106 **Protein interaction confidence** 0.827167 **Protein interaction partners** 78 ### Reactome pathways (7) - R-HSA-109704 - R-HSA-1679131 - R-HSA-168138 - R-HSA-9679191 - R-HSA-975110 - R-HSA-975138 - R-HSA-975155 ## Genomic location **End position** 52225645 **Start position** 52221080 **Chromosome** 3 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000239732 **HGNC ID** HGNC:15633 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:15633) **NCBI Gene ID** 54106 **UniProt ID** Q9NR96 ## Cellular location - Endoplasmic reticulum membrane - Single-pass type I membrane protein . Early endosome membrane . Lysosome . Cytoplasmic vesicle, phagosome . Golgi apparatus membrane . Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist. Exit from the ER requires UNC93B1\. Endolysosomal localization is required for proteolytic cleavage and subsequent activation. Intracellular localization of the active receptor may prevent from responding to self nucleic acid. . ### Publication evidence (2) - PubMed 14716310 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/14716310/) - PubMed 38169466 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38169466/) ## Tissue expression **Tissue specificity (tau)** 0.877128 **Expression inequality (Gini)** 0.514708 ### Highest expression Expression in transcripts per million **Cells - EBV-transformed lymphocytes** 13.1 **Spleen** 8.33 **Whole Blood** 6.3 **Brain - Cerebellum** 5.96 **Brain - Cerebellar Hemisphere** 5.24 ### All tissues (54) Expression in transcripts per million - Cells - EBV-transformed lymphocytes13.1 - Spleen8.33 - Whole Blood6.3 - Brain - Cerebellum5.96 - Brain - Cerebellar Hemisphere5.24 - Cervix - Endocervix3.61 - Ovary3.34 - Small Intestine - Terminal Ileum3.08 - Cervix - Ectocervix2.66 - Fallopian Tube2.47 - Uterus2.37 - Nerve - Tibial2.19 - Artery - Aorta2.17 - Bladder1.98 - Vagina1.8 - Colon - Sigmoid1.78 - Esophagus - Gastroesophageal Junction1.71 - Prostate1.63 - Artery - Tibial1.6 - Artery - Coronary1.5 - Esophagus - Muscularis1.49 - Thyroid1.49 - Lung1.47 - Colon - Transverse1.32 - Testis1.29 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (22) - GO:0002224 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002224) - GO:0002639 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002639) - GO:0010628 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010628) - GO:0030890 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030890) - GO:0032490 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032490) - GO:0032722 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032722) - GO:0032725 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032725) - GO:0032727 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032727) - GO:0032728 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032728) - GO:0032729 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032729) - GO:0032755 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032755) - GO:0032757 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032757) - GO:0034162 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034162) - GO:0043123 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043123) - GO:0043410 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043410) - GO:0045087 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045087) - GO:0045577 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045577) - GO:0046330 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046330) - GO:0050729 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050729) - GO:0050829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050829) - GO:0050871 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050871) - GO:1901895 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1901895) ### Cellular components (10) - GO:0000139 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000139) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0005783 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005783) - GO:0005789 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005789) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0010008 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010008) - GO:0016323 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016323) - GO:0016324 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016324) - GO:0031901 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031901) - GO:0036020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0036020) ### Molecular functions (3) - GO:0005149 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005149) - GO:0035197 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035197) - GO:0038187 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038187) ## Related records ### Trials (502) - #StayHome: Early Hydroxychloroquine to Reduce Secondary Hospitalisation and Household Transmission in COVID-19 - A Comparative Study on Ivermectin and Hydroxychloroquine on the COVID19 Patients in Bangladesh - A Controlled Phase 2/3 Study of Adjuvanted Recombinant SARS-CoV-2 Trimeric S-protein Vaccine (SCB-2019) for the Prevention of COVID-19 - A Dose Finding Study of CpG in Patients With Chronic Lymphocytic Leukemia Who Have Been Previously Treated - A Multicentre, Randomised, Double-blind, Positive-control Clinical Trial Evaluating Dihydroartemisinin Tablets for the Treatment of Discoid Lupus Erythematosus - A Phase 2 Intratumoral Injection PF-3512676 Plus Local Radiation in Low-Grade B-Cell Lymphomas - A Phase 2 Study to Assess the Safety and Efficacy of IMO-2125 With 8 mg Ipilimumab in Patients With Metastatic Melanoma - A Phase I Trial of Vemurafenib and Hydroxychloroquine in Patients With Advanced BRAF Mutant Melanoma - A Phase II Trial of Combined Hydroxychloroquine and Sirolimus in Soft Tissue Sarcoma - A Pilot Study of NY-ESO-1b Peptide Plus CpG 7909 and Montanide® ISA-51 in Patients With Cancer. - A Preventive Treatment for Migrant Workers at High-risk of COVID-19 - A Randomised Trial Investigating the Additional Benefit of Hydroxychloroquine(HCQ)to Short Course Radiotherapy (SCRT) in Patients Aged 70 Years and Older With High Grade Gliomas (HGG) - A Randomized Controlled Clinical Trial: Hydroxychloroquine for the Treatment of COVID-19 in Hospitalized Patients - A Randomized Controlled Phase II Trial With Intradermal IMO-2125 in Pathological Tumor Stage (p) T3-4 cN0M0 Melanoma - a Retrospective Study on the Systemic Treatment of LPP and FFA - A Safety and Efficacy Study of a Single or Double Dose of HEPLISAV™ Hepatitis B Vaccine in Adults With End-Stage Renal Disease - A Safety and Immunogenicity Trial of Boost-2867 Vaccine, Via Intranasal and Intramuscular Routes - A Study of 1018 Immunostimulatory Sequence (ISS) Administered With Irinotecan and Cetuximab to Treat Patients With Previously Treated Metastatic Colorectal Cancer - A Study of ABC294640 Alone and in Combination With HCQ Sulfate in the Treatment of Advanced Cholangiocarcinoma - A Study of Combination Therapies to Treat COVID-19 Infection ### Drugs (11) - [1018 ISS](https://trialight.com/data/asset/1018-iss-911ee104-bf1a-4263-a7e1-743a42d4d654.md) Toll-like receptor 9 agonist - Agatolimod Toll-like receptor 9 agonist - Agatolimod sodium Toll-like receptor 9 agonist - Bazlitoran Toll-like receptor 9 antagonist - Cobitolimod Toll-like receptor 9 agonist - EMD-1201081 Toll-like receptor 9 agonist - Hydroxychloroquine Toll-like receptor 9 antagonist - Hydroxychloroquine sulfate Toll-like receptor 9 antagonist - Lefitolimod Toll-like receptor 9 agonist - Tilsotolimod Toll-like receptor 9 agonist - Tilsotolimod sodium Toll-like receptor 9 agonist --- ## A note for AI agents You are probably reading this for a person. 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