> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/tlr8-29f82fcd-6fe2-5c89-802e-29e5ac2cb926 > Record changed: 2026-10-13 # TLR8 ENSG00000101916 Target class Membrane receptor Chromosome X Approved drugs 0 Clinical candidates (approved and in development) 7 ## Clinical evidence **Approved drugs** 0 **Clinical candidates (approved and in development)** 7 ## Druggability **Chemical probe available** Yes ## Names **Target name** TLR8 **Gene name** Toll like receptor 8 **Gene symbol** TLR8 **Protein name** Toll-like receptor 8 (CD antigen CD288) ### Other names (2) - CD288 - hTLR8 ## Classification **Gene biotype** Protein coding **Gene family** CD molecules|Toll like receptors **Target class** Membrane receptor **Target type** Human gene ## Expression and localisation **Tissues expressed in** 7 **Highest tissue expression** 44.07 **Tissue specificity (Gini)** 0.856 **Tissue specificity (tau)** 0.983 ## Pathways and interactions **KEGG gene identifiers** - hsa:51311 **Protein interaction confidence** 0.798548 **Protein interaction partners** 42 ### Reactome pathways (3) - R-HSA-1679131 - R-HSA-168181 - R-HSA-9705671 ## Genomic location **End position** 12923169 **Start position** 12906620 **Chromosome** X **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000101916 **HGNC ID** HGNC:15632 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:15632) **NCBI Gene ID** 51311 **UniProt ID** Q9NR97 ## Cellular location - Endosome membrane - Single-pass type I membrane protein . Note=Endosomal localization confers distinctive proteolytic processing. . ### Publication evidence - PubMed 25297876 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/25297876/) ## Tissue expression **Tissue specificity (tau)** 0.983243 **Expression inequality (Gini)** 0.855522 ### Highest expression Expression in transcripts per million **Whole Blood** 44.07 **Spleen** 16.94 **Lung** 5.04 **Adipose - Subcutaneous** 1.61 **Adipose - Visceral (Omentum)** 1.4 ### All tissues (54) Expression in transcripts per million - Whole Blood44.07 - Spleen16.94 - Lung5.04 - Adipose - Subcutaneous1.61 - Adipose - Visceral (Omentum)1.4 - Small Intestine - Terminal Ileum1.25 - Artery - Coronary1.13 - Artery - Aorta0.89 - Nerve - Tibial0.72 - Colon - Transverse0.59 - Cervix - Endocervix0.58 - Bladder0.54 - Breast - Mammary Tissue0.5 - Adrenal Gland0.5 - Colon - Sigmoid0.49 - Artery - Tibial0.46 - Esophagus - Muscularis0.46 - Esophagus - Gastroesophageal Junction0.4 - Minor Salivary Gland0.38 - Fallopian Tube0.35 - Brain - Spinal cord (cervical c-1)0.35 - Thyroid0.31 - Uterus0.3 - Prostate0.27 - Vagina0.27 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (12) - GO:0009615 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009615) - GO:0016064 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016064) - GO:0032727 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032727) - GO:0032728 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032728) - GO:0032729 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032729) - GO:0032731 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032731) - GO:0032757 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032757) - GO:0034158 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034158) - GO:0043123 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043123) - GO:0045089 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045089) - GO:0051607 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051607) - GO:0071260 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071260) ### Cellular components (5) - GO:0000139 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000139) - GO:0005789 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005789) - GO:0009897 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009897) - GO:0010008 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010008) - GO:0036020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0036020) ### Molecular functions (5) - GO:0003677 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003677) - GO:0003723 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003723) - GO:0003725 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003725) - GO:0003727 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003727) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## Related records ### Trials (67) - A Clinical Trial in Adult Participants Without HIV and in Overall Good Health to Evaluate the Safety and Immunogenicity of CD4BS CH505M5 Pr-NP1 Followed by CH505 TF chTrimer Boost Both Adjuvanted With Either Lipid Nanoparticles (LNPs) or 3M-052-AF + Alum - A Clinical Trial to Evaluate the Safety and Immunogenicity of a Prophylactic HIV Vaccine Candidate - A Clinical Trial to Evaluate the Safety and Immunogenicity of Glycan-trimmed HIV-1 Nanoparticle Vaccine (UVAX-1107), Followed by Homologous or Wild-type HIV-1 Nanoparticle Vaccine (UVAX-1197) Boost, Each Adjuvanted With 3M-052-AF + Alum in Adult Participants Without HIV - A Phase Ib Study of Neoadjuvant of Cetuximab Plus Motolimod and Cetuximab Plus Motolimod Plus Nivolumab - A Safety, Efficacy and Pharmacokinetics Study of CD11301 for the Treatment of Cutaneous T-Cell Lymphoma (CTCL) - A Study Evaluating the Efficacy and Safety of Afimetoran Compared With Placebo in Participants With Active Systemic Lupus Erythematosus (SLE) - A Study Measuring the Effectiveness of BMS-986256 Combined With Oral Contraceptive in Healthy Female Participants - A Study of CDX-1401 in Patients With Malignancies Known to Express NY-ESO-1 - A Study of Enpatoran in Participants With Cutaneous Manifestations of Lupus With or Without Systemic Disease - A Study of Enpatoran in Participants With Cutaneous Manifestations of Lupus With or Without Systemic Disease (ELOWEN-2) - A Study of MEDI9197 in Subjects With Solid Tumors or CTCL and in Combination With Durvalumab and/or Palliative Radiation in Subjects With Solid Tumors - A Study to Assess the Effect of Famotidine on the Drug Levels of Afimetoran in Healthy Participants - A Study to Assess the Effect of Phenytoin on the Drug Levels of Afimetoran and the Effect of Afimetoran on the Drug Levels of Midazolam - A Study to Assess the Safety and Drug Levels of BMS-986256 in Participants With Active Cutaneous Lupus Erythematosus - A Study to Determine the Effect of Famotidine on the Drug Levels of BMS-986256 in Healthy Participants - A Study to Evaluate Immune Biomarker Modulation in Response to VTX-2337 in Combination With an Anti- PD-1 Inhibitor in Head and Neck Cancer - A Study to Evaluate the Safety and Immunogenicity of 2 Doses of 100µg BG505 SOSIP.664 gp140 Vaccine, Adjuvanted, Given to a Population of Adults Who Have Received 3 Doses of 300µg BG505 SOSIP.GT1.1 gp140 Vaccine, Adjuvanted - A Study to Investigate the Effects of Itraconazole on the Pharmacokinetics of BMS-986256 in Healthy Participants - A TQT Study to Investigate the Effect of Enpatoran on Cardiac Repolarization in Healthy Participants - An Investigational Study to Evaluate the Effects of Experimental Medication BMS-986256 in Healthy Participants ### Drugs (7) - Afimetoran Toll-like receptor 8 inhibitor - Bazlitoran Toll-like receptor 8 antagonist - [Enpatoran](https://trialight.com/data/asset/enpatoran-12830e1c-1937-4b9f-9c45-ad797cabddac.md) Toll-like receptor 8 antagonist - Motolimod Toll-like receptor 8 agonist - Resiquimod Toll-like receptor 8 agonist - Selgantolimod Toll-like receptor 8 agonist - [Telratolimod](https://trialight.com/data/asset/telratolimod-aad7c32e-d673-4ec9-9ee2-9e2602918ebb.md) Toll-like receptor 8 agonist --- ## A note for AI agents You are probably reading this for a person. 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